Cytotoxicity of diesel engine exhaust among the Chinese occupational population: a complement of cytokinesis-block micronucleus cytome.

abstract：:In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle prope...

journal_title：Inhalation toxicology

authors： Maier KL,Alessandrini F,Beck-Speier I,Hofer TP,Diabaté S,Bitterle E,Stöger T,Jakob T,Behrendt H,Horsch M,Beckers J,Ziesenis A,Hültner L,Frankenberger M,Krauss-Etschmann S,Schulz H

更新日期：2008-02-01 00:00:00

abstract：:Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...

journal_title：Inhalation toxicology

authors： Mossman B,Hubbard A,Shukla A,Timblin CR

更新日期：2000-01-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：:Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...

journal_title：Inhalation toxicology

authors： Chuang CY,Chang CH,Huang YL

更新日期：2009-02-01 00:00:00

abstract：:This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-06-01 00:00:00

abstract：:Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...

journal_title：Inhalation toxicology

authors： Borm PJ,Höhr D,Steinfartz Y,Zeitträger I,Albrecht C

更新日期：2000-01-01 00:00:00

abstract：:Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

journal_title：Inhalation toxicology

authors： Maxim LD,McConnell EE

更新日期：2005-08-01 00:00:00

abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...

journal_title：Inhalation toxicology

authors： Graham JR,Wright BS,Rezk PE,Gordon RK,Sciuto AM,Nambiar MP

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...

journal_title：Inhalation toxicology

authors： Walker AM,Maxim LD,Utell MJ

更新日期：2012-06-01 00:00:00

abstract：:Epidemiological studies have reported increased morbidity in human populations following inhalation of elevated levels of urban particulate matter. These responses are especially prevalent in populations with chronic obstructive pulmonary diseases, including chronic bronchitis. Toxicological studies have reported alte...

journal_title：Inhalation toxicology

authors： Clarke RW,Catalano PJ,Koutrakis P,Murthy GG,Sioutas C,Paulauskis J,Coull B,Ferguson S,Godleski JJ

更新日期：1999-08-01 00:00:00

abstract：CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

journal_title：Inhalation toxicology

authors： Seagrave J,Weber WM,Grotendorst GR

更新日期：2010-09-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...

journal_title：Inhalation toxicology

authors： Kuempel ED,Tran CL,Castranova V,Bailer AJ

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...

journal_title：Inhalation toxicology

authors： Yıldırım F,Çevik Y,Emektar E,Çorbacıoğlu ŞK,Katırcı Y

更新日期：2016-10-01 00:00:00

abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...

journal_title：Inhalation toxicology

authors： Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen F

更新日期：2007-08-01 00:00:00

abstract：:This article addresses the importance of blood pressure as a covariate in studies of long-term associations between air quality and mortality. We focus on a cohort of about 50,000 U.S. veterans who had been diagnosed as hypertensive at some time and whose survival rates were predicted by blood pressure (BP) and ambien...

journal_title：Inhalation toxicology

authors： Lipfert FW,Perry HM Jr,Miller JP,Baty JD,Wyzga RE,Carmody SE

更新日期：2003-04-25 00:00:00

abstract：:Rats were exposed to a new graphite whisker for 4 wk by inhalation. Mass and fiber concentrations were 8.3 +/- 2.2 mg/m3 and 151.7 +/- 78.8 fibers (F)/ml, respectively, and mass median aerodynamic diameter was 3.0 micro m. Geometric mean sizes of the original whiskers were 0.86 micro m diameter and 6.8 micro m length....

journal_title：Inhalation toxicology

authors： Ishimatsu S,Hori H,Oyabu T,Tanaka I

更新日期：2003-01-01 00:00:00

abstract：:Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi...

journal_title：Inhalation toxicology

authors： McKinney W,Chen B,Frazer D

更新日期：2009-10-01 00:00:00

abstract：:The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...

journal_title：Inhalation toxicology

authors： Hälinen AI,Pennanen AS,Salonen RO

更新日期：2000-08-01 00:00:00

abstract：:To elucidate dose-response and other effects of diesel particles in guinea pigs chronically exposed to diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens. Guinea pigs were exposed 16 h/day, 6 days/wk, for 6, 12, 18, or 24 m...

journal_title：Inhalation toxicology

authors： Ishihara Y,Kagawa J

更新日期：2002-10-01 00:00:00

abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...

journal_title：Inhalation toxicology

authors： DeLorme MP,Himmelstein MW,Kemper RA,Kegelman TA,Gargas ML,Kinzell JH

更新日期：2009-05-01 00:00:00

abstract：:During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...

journal_title：Inhalation toxicology

authors： Chate D,Beig G,Satpute T,Sahu SK,Ali K,Parkhi N,Ghude S

更新日期：2013-05-01 00:00:00

abstract：:Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...

journal_title：Inhalation toxicology

authors： Kelly JT,Asgharian B,Wong BA

更新日期：2005-12-15 00:00:00

abstract：:Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...

journal_title：Inhalation toxicology

authors： Warman M,Tiomkin E,Huszar M,Halperin D,Asher I,Cohen O

更新日期：2020-05-01 00:00:00

abstract：:The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. However, while the population exposed to silver nanoparticles continues to increase with ever new applications, silver nanoparticles remain a controversial research area as regards the...

journal_title：Inhalation toxicology

authors： Kim YS,Kim JS,Cho HS,Rha DS,Kim JM,Park JD,Choi BS,Lim R,Chang HK,Chung YH,Kwon IH,Jeong J,Han BS,Yu IJ

更新日期：2008-04-01 00:00:00

abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...

journal_title：Inhalation toxicology

authors： Webber JS,Getman M,Ward TJ

更新日期：2006-11-01 00:00:00

abstract：:This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...

journal_title：Inhalation toxicology

authors： Rundell KW,Hoffman JR,Caviston R,Bulbulian R,Hollenbach AM

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...

journal_title：Inhalation toxicology

authors： Świątkowska B,Szeszenia-Dąbrowska N

更新日期：2017-01-01 00:00:00