Abstract：
:A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) or clean air by whole-body inhalation for 6 h/day from day 6 to 19 post conceptionem (p.c.) and from day 5 to 21 post partum (p.p.). Pups were cross-fostered to new dams within the first 2 days after birth. Treatment of the mothers with HCFC-123 led to decreases in serum glucose, cholesterol, and triglycerides and increases in absolute and relative maternal liver weights. Decreased litter and individual pup weight and decreased serum triglycerides were observed in the pups of treated foster mothers. Treatment of the mothers with HCFC-123 did not influence milk production based on the body weight difference of the dam before suckling and 60 min after beginning of suckling using 12-pup "standard litters" of untreated dams. Total fat, glucose, and protein contents in the milk were also not influenced by the treatment. Trifluoroacetic acid (TFA), a main metabolite of HCFC-123, was observed in urine samples of standard litters that had been nursed by treated dams. In conclusion, the effects on offspring due to HCFC-123 treatment consisted of decreased pup weight and decreased serum triglycerides at weaning. All effects were due to treatment of the lactating dams, as no prenatally induced effects were found. Since milk production and nutritional constituents of the milk were not influenced, but significant amounts of the main metabolite were found in pup urine, an effect of HCFC-123 or its metabolite on the pups via maternal milk is considered to be a possible cause for their decreased weight gain.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Buschmann J,Bartsch W,Dasenbrock C,Fuhst R,Pohlmann G,Preiss A,Berger-Preiss Edoi
10.1080/08958370126866subject
Has Abstractpub_date
2001-08-01 00:00:00pages
671-87issue
8eissn
0895-8378issn
1091-7691journal_volume
13pub_type
杂志文章abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958378.2017.1336187
更新日期：2017-03-01 00:00:00
abstract：:This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.804609
更新日期：2013-07-01 00:00:00
abstract：:Elastolysis, collagenolysis and gelatinolysis are essential in the pathogenesis of tobacco smoke-induced emphysema; however, these activities have been scantily studied in emphysema secondary to woodsmoke. The aim of this study was to analyze elastolysis, collagenolysis and gelatinolysis, MMP-1, MMP-2, and MMP-9 expre...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802419145
更新日期：2009-02-01 00:00:00
abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370500188984
更新日期：2005-11-01 00:00:00
abstract：CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.572932
更新日期：2011-05-01 00:00:00
abstract：:Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2000.11463217
更新日期：2000-01-01 00:00:00
abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701432157
更新日期：2007-08-01 00:00:00
abstract：:Diesel engine exhaust (DEE), a ubiquitous environmental pollutant, has been associated with adverse health effects. Revelation of cellular and molecular changes is critical for understanding environmental exposure-related diseases. Although the molecular-level effects of DEE exposure have been investigated, whether it...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2016.1162233
更新日期：2016-01-01 00:00:00
abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title：Inhalation toxicology
pub_type： 历史文章,杂志文章
doi：10.1080/08958370600835138
更新日期：2006-11-01 00:00:00
abstract：:The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2016.1175527
更新日期：2016-07-01 00:00:00
abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1720867
更新日期：2020-01-01 00:00:00
abstract：:Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.584919
更新日期：2011-07-01 00:00:00
abstract：:In 1997 The International Agency for Research on Cancer classified some exposures to crystalline silica as carcinogenic to humans. Such exposures were acknowledged to be very variable, and even in the same monograph it was admitted that coal dust, containing as much as 20% quartz, could not be classified. Clearly ther...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802136731
更新日期：2008-09-01 00:00:00
abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583701753210371
更新日期：2001-11-01 00:00:00
abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958370590885672
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2015.1060278
更新日期：2015-01-01 00:00:00
abstract：:It is important to conduct a risk assessment that includes hazard assessment and exposure assessment for the safe production and handling of newly developed nanomaterials. We conducted an inhalation study of a multi-wall carbon nanotube (MWCNT) as a hazard assessment. Male Wistar rats were exposed to well-dispersed MW...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.608096
更新日期：2011-11-01 00:00:00
abstract：:This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370050164626
更新日期：2000-11-01 00:00:00
abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370590912851
更新日期：2005-04-01 00:00:00
abstract：:Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2019.1698678
更新日期：2019-01-01 00:00:00
abstract：:This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370118600
更新日期：2001-06-01 00:00:00
abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802596926
更新日期：2009-05-01 00:00:00
abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583799197096
更新日期：1999-04-01 00:00:00
abstract：:The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802590499
更新日期：2009-09-01 00:00:00
abstract：:NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to those of lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701821219
更新日期：2008-01-01 00:00:00
abstract：:The purpose of the Enhanced Particulate Matter Surveillance Program was to provide scientifically founded information on the chemical and physical properties of dust collected over a period of approximately 1 year in Djibouti, Afghanistan (Bagram, Khowst), Qatar, United Arab Emirates, Iraq (Balad, Baghdad, Tallil, Tik...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802464273
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...
journal_title：Inhalation toxicology
pub_type： 临床试验,杂志文章
doi：10.1080/08958378.2016.1224957
更新日期：2016-10-01 00:00:00
abstract：:Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370390197254
更新日期：2003-06-01 00:00:00
abstract：:The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958370902934894
更新日期：2010-02-01 00:00:00
abstract：:Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701516108
更新日期：2007-09-01 00:00:00
