Abstract：
:Elastolysis, collagenolysis and gelatinolysis are essential in the pathogenesis of tobacco smoke-induced emphysema; however, these activities have been scantily studied in emphysema secondary to woodsmoke. The aim of this study was to analyze elastolysis, collagenolysis and gelatinolysis, MMP-1, MMP-2, and MMP-9 expression, and apoptosis in guinea pigs exposed to smoke produced by 60 g/day of pine wood, 5 days/week, from 1 to 7 months. Histological analysis after 4 to 7 months in smoke exposed guinea pigs showed alveolar mononuclear phagocyte and lymphocytic peribronchiolar inflammation, epithelial and smooth muscle hyperplasia, and pulmonary arterial hypertension. Mild to moderate emphysematous lesions were observed in woodsmoke-exposed animals at 4 to 7 months by increase of mean linear intercepts. A higher percentage of whole blood carboxyhemoglobin (COHb) and elastolytic activity in bronchoalveolar lavage macrophages and lung tissue homogenates was observed at all times. Collagenolysis was increased after 4 to 7 months in woodsmoke-exposed animals, although collagen concentration did not change. Zymography revealed increase in lysis bands of the active MMP-2 and MMP-9 at 4 and 7 months in bronchoalveolar lavage fluid and lung tissue homogenate. Positive immunostaining for MMP-1 and MMP-9 was observed in epithelial cells and macrophages in wood exposed animals at 4 to 7 months. Real-time PCR showed MMP-2 and MMP-9 expression at 3 to 7 months in exposed animals. Furthermore, apoptosis was increased at all times in bronchoalveolar lavage macrophages and lung tissue from exposed animals. Results support a role of metalloproteinases and apoptosis in emphysema secondary to woodsmoke exposure.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Ramos C,Cisneros J,Gonzalez-Avila G,Becerril C,Ruiz V,Montaño Mdoi
10.1080/08958370802419145subject
Has Abstractpub_date
2009-02-01 00:00:00pages
119-32issue
2eissn
0895-8378issn
1091-7691pii
903313409journal_volume
21pub_type
杂志文章abstract：:Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701353205
更新日期：2007-06-01 00:00:00
abstract：:Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802015091
更新日期：2008-07-01 00:00:00
abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003596587
更新日期：2010-06-01 00:00:00
abstract：:Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to estimate tissue metabolism rates and partitioning, and to apply the model to calculate an inhalation unit risk (IUR) for chloroprene.Materials and methods: Female B6C...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1715513
更新日期：2019-01-01 00:00:00
abstract：:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.920440
更新日期：2014-09-01 00:00:00
abstract：:In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the "Magic Nano Glass & Ceramic" spray and "Magic Nano Bath" spray. In contrast, the previously marketed "Magic Nano" pump spray product (handheld trigger device without propell...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802220634
更新日期：2008-11-01 00:00:00
abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...
journal_title：Inhalation toxicology
pub_type： 临床试验,杂志文章
doi：10.1080/08958378.2016.1224957
更新日期：2016-10-01 00:00:00
abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title：Inhalation toxicology
pub_type： 历史文章,杂志文章
doi：10.1080/08958370600835138
更新日期：2006-11-01 00:00:00
abstract：:Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant increase in polymorphonuclear leukocytes (PMN), total protein and albumin ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.751143
更新日期：2013-01-01 00:00:00
abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1754972
更新日期：2020-02-01 00:00:00
abstract：:Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2000.11463240
更新日期：2000-01-01 00:00:00
abstract：:Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370304468
更新日期：2003-05-01 00:00:00
abstract：:This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370601051727
更新日期：2007-02-01 00:00:00
abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2000.11463207
更新日期：2000-01-01 00:00:00
abstract：CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.708065
更新日期：2012-08-01 00:00:00
abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701432157
更新日期：2007-08-01 00:00:00
abstract：:Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958370701495998
更新日期：2007-01-01 00:00:00
abstract：:Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583799197276
更新日期：1999-01-01 00:00:00
abstract：:Manganese (Mn) is ubiquitous in ambient air due to both industrial and crustal sources. It is also a component of the octane-enhancing fuel additive methylcyclopentadienyl manganese tricarbonyl (MMT). The combustion of MMT by the automobile engine results in the formation of Mn particulates including phosphate, sulfat...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370050138003
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1809572
更新日期：2020-07-01 00:00:00
abstract：:Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958370902744855
更新日期：2009-11-01 00:00:00
abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958370590885672
更新日期：2005-01-01 00:00:00
abstract：:Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370902962317
更新日期：2009-07-01 00:00:00
abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2010.566291
更新日期：2011-08-01 00:00:00
abstract：:Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370290084584
更新日期：2002-07-01 00:00:00
abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600686341
更新日期：2006-07-01 00:00:00
abstract：:We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370252871005
更新日期：2002-04-01 00:00:00
abstract：CONTEXT:Eleven carbohydrates and natural product ingredients were added individually to experimental cigarettes. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from these experimental cigarettes to matched control cigarettes without test ingredients. MATERIALS AND METHODS:Smoke fraction...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.545085
更新日期：2011-06-01 00:00:00
abstract：:This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802409567
更新日期：2009-02-01 00:00:00
abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1720867
更新日期：2020-01-01 00:00:00
