Abstract:
:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel methods for detecting evidence of past airborne asbestos contamination. In each of these studies, transmission electron microscopy was used to identify and measure asbestos fibers collected in samples from unconventional environmental sources. In the first study, paleolimnology, analytical transmission electron microscopy, particle-separation techniques, and empirical aerosol-sediment modeling were combined to provide the first measurements of airborne asbestos concentrations prior to the 1980s. In an upstate New York study area, airborne concentrations of chrysotile followed its 20th-century usage, with highest concentrations near mid-century (approximately 0.1 fibers/cm3), followed by a decrease in the last quarter century. Airborne concentrations of anthophyllite asbestos (a contaminant from nearby talc mines and mills) increased from <0.004 to 0.022 fibers/cm3 from 1847 to 1995. In the second study, tree bark and core samples were collected from areas near the asbestos-contaminated vermiculite mine in Libby, MT. We originally hypothesized that trees in the areas surrounding the mine could serve as reservoirs for ambient amphibole fibers. Though gravimetric reduction of a tree core sample did not indicate the presence of amphibole fibers, transmission electron microscopy analysis of bark samples yielded substantial amphibole fiber concentrations ranging from 14 to 260 million amphibole fibers/cm2. Based on these preliminary results, we conclude that trees in the Libby valley can serve as reservoirs for amphibole fibers, and that a continued potential for exposure exists for those who harvest contaminated wood.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Webber JS,Getman M,Ward TJdoi
10.1080/08958370600835138subject
Has Abstractpub_date
2006-11-01 00:00:00pages
969-73issue
12eissn
0895-8378issn
1091-7691pii
G5G2228440814X42journal_volume
18pub_type
历史文章,杂志文章abstract::This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802409567
更新日期:2009-02-01 00:00:00
abstract::The C9 alkylbenzenes, composed mostly of ethyltoluenes and trimethylbenzenes, comprise 75-90% of the naphtha fraction of crude oil. Occupational and environmental exposure to C9 alkylbenzenes occur via inhalation. We conducted short-term inhalation studies on the ethyltoluene isomers (2-, 3- or 4-) to select one isome...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2018.1430190
更新日期:2017-01-01 00:00:00
abstract::Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600602116
更新日期:2006-06-01 00:00:00
abstract::Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463240
更新日期:2000-01-01 00:00:00
abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902828468
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Increases in particulate matter less than 2.5 µm (PM(2.5)) in ambient air is linked to acute cardiovascular morbidity and mortality. Specific components and potential emission sources of PM(2.5) responsible for adverse health effects of cardiovascular function are unclear. METHODS:Spontaneously hypertensive...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.580387
更新日期:2011-06-01 00:00:00
abstract:CONTEXT:High malaria burden has led to the increased use of insecticides in the tropics and subtropics. This study thus aimed at assessing the hematological effects alteration of pyrethroid insecticide exposure using the experimental animal model. OBJECTIVE:A commonly available Electric Mosquito-Repellent Liquid pyret...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.781251
更新日期:2013-04-01 00:00:00
abstract::Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2016.1146808
更新日期:2016-01-01 00:00:00
abstract::Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.907587
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1809572
更新日期:2020-07-01 00:00:00
abstract::Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08958370252809086
更新日期:2002-03-01 00:00:00
abstract::This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390229843
更新日期:2003-10-01 00:00:00
abstract::Cigarette smoke exposures in mice have been conducted under various exposure conditions using different strains as animal models of smoke-related diseases. We exposed cigarette smoke to two strains of mice [C57BL/6J (C57) and AKR/J (AKR)] under two different exposure regimens (1 h or 4 h/day) at equivalent daily expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.596851
更新日期:2011-08-01 00:00:00
abstract::Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. To explore the exposu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.636086
更新日期:2012-01-01 00:00:00
abstract::Background: High-mobility group box 1 (HMGB1) protein plays an important pathogenic role in various diseases such as pulmonary fibrosis. However, the relationship between variation of HMGB1 gene and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The objective of the study was to determine the as...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1764153
更新日期:2020-03-01 00:00:00
abstract::Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370902962317
更新日期:2009-07-01 00:00:00
abstract::Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701495998
更新日期:2007-01-01 00:00:00
abstract::Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903341891
更新日期:2010-03-01 00:00:00
abstract::Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500241270
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.953275
更新日期:2014-10-01 00:00:00
abstract:CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.493901
更新日期:2010-09-01 00:00:00
abstract::In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the "Magic Nano Glass & Ceramic" spray and "Magic Nano Bath" spray. In contrast, the previously marketed "Magic Nano" pump spray product (handheld trigger device without propell...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802220634
更新日期:2008-11-01 00:00:00
abstract::Rats were exposed to a new graphite whisker for 4 wk by inhalation. Mass and fiber concentrations were 8.3 +/- 2.2 mg/m3 and 151.7 +/- 78.8 fibers (F)/ml, respectively, and mass median aerodynamic diameter was 3.0 micro m. Geometric mean sizes of the original whiskers were 0.86 micro m diameter and 6.8 micro m length....
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370304453
更新日期:2003-01-01 00:00:00
abstract::The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.922648
更新日期:2014-07-01 00:00:00
abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802304123
更新日期:2008-07-01 00:00:00
abstract::During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.788103
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.592869
更新日期:2011-08-01 00:00:00
abstract::The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of thes...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583700196563
更新日期:2000-01-01 00:00:00
abstract::Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1754972
更新日期:2020-02-01 00:00:00