Abstract:
:The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the formation of reactive oxygen species and inflammation. Beyond the respiratory system, O3 exposure also produces fatigue, lethargy, headaches, and significant decrease in rapid-eye-movement sleep related to an increase in slow-wave sleep. Interestingly, these sleep changes can be significantly mitigated by treatment with indomethacin, which suggests that an inflammatory mechanism may be responsible for these neurological symptoms. To characterize the inflammatory mechanisms by which O3 affects tissues outside the pulmonary system, we evaluated inflammatory factors in both lung and brain. Rats exposed to 1 part per million O3 for 1, 3 or 6 h, as well as rats exposed daily for 1 or 3 h over five consecutive days, showed increases in TNF-α and IL-6 levels within the lungs as well as increases in TNF-α, IL-6, NF-κB p50 and GFAP levels in the cerebral cortex. These results support the hypothesis that the neuroinflammatory response may be responsible for the central nervous system effects of O3 exposure.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
González-Guevara E,Martínez-Lazcano JC,Custodio V,Hernández-Cerón M,Rubio C,Paz Cdoi
10.3109/08958378.2014.922648subject
Has Abstractpub_date
2014-07-01 00:00:00pages
485-91issue
8eissn
0895-8378issn
1091-7691journal_volume
26pub_type
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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doi:10.1080/08958370600748349
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abstract::Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...
journal_title:Inhalation toxicology
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doi:10.1080/08958370151126284
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abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
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doi:10.1080/089583799197096
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journal_title:Inhalation toxicology
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abstract:OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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abstract::The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...
journal_title:Inhalation toxicology
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更新日期:2010-06-01 00:00:00
abstract::The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章
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abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
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doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::Tire and road wear particles (TRWP) are a component of ambient particulate matter (PM) produced from the interaction of tires with the roadway. Inhalation of PM has been associated with cardiopulmonary morbidities and mortalities thought to stem from pulmonary inflammation. To determine whether TRWP may contribute to ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.730071
更新日期:2012-11-01 00:00:00
abstract::This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...
journal_title:Inhalation toxicology
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doi:10.3109/08958378.2013.804609
更新日期:2013-07-01 00:00:00
abstract:CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2014.920439
更新日期:2014-08-01 00:00:00
abstract::Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...
journal_title:Inhalation toxicology
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doi:10.1080/08958370802368730
更新日期:2009-02-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1076910
更新日期:2015-01-01 00:00:00
abstract::Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...
journal_title:Inhalation toxicology
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doi:10.1080/08958370701516108
更新日期:2007-09-01 00:00:00
abstract::Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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journal_title:Inhalation toxicology
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doi:10.3109/08958378.2013.827284
更新日期:2013-09-01 00:00:00
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050198566
更新日期:2000-12-01 00:00:00
abstract::The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...
journal_title:Inhalation toxicology
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doi:10.1080/08958378.2017.1358778
更新日期:2017-05-01 00:00:00
abstract:CONTEXT:High malaria burden has led to the increased use of insecticides in the tropics and subtropics. This study thus aimed at assessing the hematological effects alteration of pyrethroid insecticide exposure using the experimental animal model. OBJECTIVE:A commonly available Electric Mosquito-Repellent Liquid pyret...
journal_title:Inhalation toxicology
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doi:10.3109/08958378.2013.781251
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...
journal_title:Inhalation toxicology
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doi:10.3109/08958378.2014.953275
更新日期:2014-10-01 00:00:00
abstract::Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. Microbial infections have been ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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abstract::Because of the interest attendant to establishing an 8-h ozone (O(3)) federal air quality standard, acute pulmonary function responses to prolonged (6.6 to 8 h) O(3) exposure between 0.08 and 0. 24 ppm have been examined in chamber studies. Given time constraints for O(3) concentration changes in room-sized chambers a...
journal_title:Inhalation toxicology
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
abstract::Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2010.539290
更新日期:2011-01-01 00:00:00