Abstract:
:This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol concentrations of approximately 15, 50, and 150 fibers/ml (fiber length >20 microm) for E-glass microfiber and MMVF21. For the CMS fiber only the highest exposure concentration was used. During a 3-mo postexposure period, recovery effects were studied. In the highest exposure concentration groups, gravimetric concentrations were 17.2 mg/m3 for E-glass microfiber, 37 mg/m3 for MMVF21, and 49.5 mg/m3 for the CMS fiber. After 3 mo of exposure, lung retention of fibers longer than 20 micro m per lung was 17 x 10(6) for E-glass microfiber, 5.7 x 10(6) for MMVF21, and 0.88 x 10(6) for CMS. After 3 mo of recovery the concentration of the long fiber fraction was decreased to 38.4%, 63.9%, and 3.0% compared to original lung burden for the E-glass microfiber, MMVF21, and CMS, respectively. Biological effects measured included inflammatory and proliferative potential, histopathology lesions, and the persistence of these effects over a recovery period of 3 mo. Generally, observed effects were higher for E-glass microfiber when compared to MMVF21. The following clear dose-dependent effects on E-glass microfiber and MMVF21 exposure were observed as main findings of the study: increase in lung weight, in measured biochemical parameters and polymorphonuclear leukocytes (PMN) in the bronchoalveolar lavage fluid (BALF), in cell proliferation (BrdU-response) of terminal bronchiolar epithelium, and in interstitial fibrosis. The values observed in the proliferation assay on the carcinogenic E-glass microfiber indicate that this assay has an important predictive value with regards to potential carcinogenicity. Surprisingly, for the biosoluble CMS fiber, fibrogenic potential was detected in this study. The results of the CMS exposure group indicate that effects may be dominated by the presence of nonfibrous particles and that fibrosis may not be a predictor of carcinogenic activity of fiber samples, if the fiber preparation contains a significant fraction of nonfibrous particles. In summary, this study demonstrates the importance of fiber dust contamination by granular components. For future subchronic studies a longer posttreatment observation period would be advisable.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Bellmann B,Muhle H,Creutzenberg O,Ernst H,Müller M,Bernstein DM,Riego Sintes JMdoi
10.1080/08958370390229843subject
Has Abstractpub_date
2003-10-01 00:00:00pages
1147-77issue
12eissn
0895-8378issn
1091-7691pii
JJ86PN60GN8JJ991journal_volume
15pub_type
杂志文章abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
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doi:10.1080/089583799197096
更新日期:1999-04-01 00:00:00
abstract::The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958371003728040
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abstract::In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
abstract::In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the "Magic Nano Glass & Ceramic" spray and "Magic Nano Bath" spray. In contrast, the previously marketed "Magic Nano" pump spray product (handheld trigger device without propell...
journal_title:Inhalation toxicology
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doi:10.1080/08958370802220634
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abstract::Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600747887
更新日期:2006-09-01 00:00:00
abstract::To investigate effects of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose volatile organic compounds (VOCs) and the possible mechanism for these effects, 60 male Kunming mice were exposed in 5 similar static chambers, 0 (control) and 4 different doses of VOCs mixture (G1-4) for consecut...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.882447
更新日期:2014-03-01 00:00:00
abstract::This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...
journal_title:Inhalation toxicology
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更新日期:2001-11-01 00:00:00
abstract::This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...
journal_title:Inhalation toxicology
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doi:10.1080/08958378.2000.11720735
更新日期:2000-01-01 00:00:00
abstract:CONTEXT:Eleven carbohydrates and natural product ingredients were added individually to experimental cigarettes. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from these experimental cigarettes to matched control cigarettes without test ingredients. MATERIALS AND METHODS:Smoke fraction...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.545085
更新日期:2011-06-01 00:00:00
abstract::In 1997 The International Agency for Research on Cancer classified some exposures to crystalline silica as carcinogenic to humans. Such exposures were acknowledged to be very variable, and even in the same monograph it was admitted that coal dust, containing as much as 20% quartz, could not be classified. Clearly ther...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802136731
更新日期:2008-09-01 00:00:00
abstract::The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601069257
更新日期:2007-03-01 00:00:00
abstract::Minimally invasive approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. The potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity was investigated. Rats were expose...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.697926
更新日期:2012-08-01 00:00:00
abstract::The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) loaded with sildenafil. The SLNs were tested as a new drug delivery system (DDS) for the inhalable treatment of pulmonary hypertension in human lungs. Solubility of sildenafil in SLN lipid matrix (30:70 phospholipid:...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.810315
更新日期:2013-08-01 00:00:00
abstract::Diesel engine exhaust (DEE), a ubiquitous environmental pollutant, has been associated with adverse health effects. Revelation of cellular and molecular changes is critical for understanding environmental exposure-related diseases. Although the molecular-level effects of DEE exposure have been investigated, whether it...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2016.1162233
更新日期:2016-01-01 00:00:00
abstract::Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.695815
更新日期:2012-07-01 00:00:00
abstract::Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463217
更新日期:2000-01-01 00:00:00
abstract::Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463207
更新日期:2000-01-01 00:00:00
abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2012.757400
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Gastroesophageal reflux of bile acids plays an important role in the development of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC). Cigarette smoke has been demonstrated to exacerbate the effects of reflux and thus the initial stages of EAC carcinogenesis. To date, no in vivo studies hav...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.568977
更新日期:2011-04-01 00:00:00
abstract::Sulfur dioxide (SO2) is a common but important air pollutant. Micronuclei (MN) in the polychromatic erythrocytes (PCE) of mouse bone marrow and the ratio between organ and body weight of treatment mouse were determined and analyzed in vivo in order to study injury of sulfur dioxide inhalation on organs and germ plasm ...
journal_title:Inhalation toxicology
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更新日期:2003-09-01 00:00:00
abstract::The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did sever...
journal_title:Inhalation toxicology
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更新日期:2004-04-01 00:00:00
abstract::The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title:Inhalation toxicology
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doi:10.3109/08958370902934894
更新日期:2010-02-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::Elastolysis, collagenolysis and gelatinolysis are essential in the pathogenesis of tobacco smoke-induced emphysema; however, these activities have been scantily studied in emphysema secondary to woodsmoke. The aim of this study was to analyze elastolysis, collagenolysis and gelatinolysis, MMP-1, MMP-2, and MMP-9 expre...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802419145
更新日期:2009-02-01 00:00:00
abstract::The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章
doi:10.1080/08958370600835138
更新日期:2006-11-01 00:00:00
abstract::Nano-sized particles (NSPs) have a diameter of less than 100 nm. When inhaled, they preferentially deposit in the deeper lung, where pulmonary surfactant covers the thin aqueous lining layer. Thus, pulmonary surfactant is the initial contact where NSPs impinge. This can lead to various consequences. For example, bindi...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370903005744
更新日期:2009-07-01 00:00:00
abstract::Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...
journal_title:Inhalation toxicology
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更新日期:2006-07-01 00:00:00
abstract::Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...
journal_title:Inhalation toxicology
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doi:10.3109/08958378.2014.885099
更新日期:2014-04-01 00:00:00
abstract::Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.584919
更新日期:2011-07-01 00:00:00