Interaction of nanoparticles with the pulmonary surfactant system.

abstract：:Rats were exposed to a new graphite whisker for 4 wk by inhalation. Mass and fiber concentrations were 8.3 +/- 2.2 mg/m3 and 151.7 +/- 78.8 fibers (F)/ml, respectively, and mass median aerodynamic diameter was 3.0 micro m. Geometric mean sizes of the original whiskers were 0.86 micro m diameter and 6.8 micro m length....

journal_title：Inhalation toxicology

authors： Ishimatsu S,Hori H,Oyabu T,Tanaka I

更新日期：2003-01-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...

journal_title：Inhalation toxicology

authors： Rundell KW,Hoffman JR,Caviston R,Bulbulian R,Hollenbach AM

更新日期：2007-02-01 00:00:00

abstract：:Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...

journal_title：Inhalation toxicology

authors： Park JD,Chung YH,Kim CY,Ha CS,Yang SO,Khang HS,Yu IK,Cheong HK,Lee JS,Song CW,Kwon IH,Han JH,Sung JH,Heo JD,Choi BS,Im R,Jeong J,Yu IJ

更新日期：2007-09-01 00:00:00

abstract：CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

journal_title：Inhalation toxicology

authors： Seagrave J,Weber WM,Grotendorst GR

更新日期：2010-09-01 00:00:00

abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...

journal_title：Inhalation toxicology

authors： Webber JS,Getman M,Ward TJ

更新日期：2006-11-01 00:00:00

abstract：:With growing evidence of the association between daily mortality and air pollution in adults, it is important to investigate whether infants are also susceptible to the adverse health effects of ambient air pollutants. The purpose of this study is to examine the relationship between air pollution and postneonatal mort...

journal_title：Inhalation toxicology

authors： Tsai SS,Chen CC,Hsieh HJ,Chang CC,Yang CY

更新日期：2006-03-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00

abstract：CONTEXT:Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. OBJECTIVE:The purpose of this study is to determine the aging effects of PM exposure on the respon...

journal_title：Inhalation toxicology

authors： Bennett BA,Mitzner W,Tankersley CG

更新日期：2012-12-01 00:00:00

abstract：:In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...

journal_title：Inhalation toxicology

authors： Rödelsperger K

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...

journal_title：Inhalation toxicology

authors： Walker AM,Maxim LD,Utell MJ

更新日期：2012-06-01 00:00:00

abstract：:Fine particulate matter (PM(2.5)) is associated with respiratory effects, and asthmatic children are especially sensitive. Preliminary evidence suggests that combustion-derived particles play an important role. Our objective was to evaluate effect estimates from different PM(2.5) exposure metrics in relation to airway...

journal_title：Inhalation toxicology

authors： Allen RW,Mar T,Koenig J,Liu LJ,Gould T,Simpson C,Larson T

更新日期：2008-02-01 00:00:00

abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...

journal_title：Inhalation toxicology

authors： Alexis NE,Lay JC,Hazucha M,Harris B,Hernandez ML,Bromberg PA,Kehrl H,Diaz-Sanchez D,Kim C,Devlin RB,Peden DB

更新日期：2010-06-01 00:00:00

abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...

journal_title：Inhalation toxicology

authors： Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen F

更新日期：2007-08-01 00:00:00

abstract：:The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated response to acute ozone exposure dependent on the type and severity of disea...

journal_title：Inhalation toxicology

authors： Kodavanti UP,Ledbetter AD,Thomas RF,Richards JE,Ward WO,Schladweiler MC,Costa DL

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...

journal_title：Inhalation toxicology

authors： Perez CM,Hazari MS,Ledbetter AD,Haykal-Coates N,Carll AP,Cascio WE,Winsett DW,Costa DL,Farraj AK

更新日期：2015-01-01 00:00:00

abstract：:The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...

journal_title：Inhalation toxicology

authors： Wegesser TC,Franzi LM,Mitloehner FM,Eiguren-Fernandez A,Last JA

更新日期：2010-06-01 00:00:00

abstract：:It is important to conduct a risk assessment that includes hazard assessment and exposure assessment for the safe production and handling of newly developed nanomaterials. We conducted an inhalation study of a multi-wall carbon nanotube (MWCNT) as a hazard assessment. Male Wistar rats were exposed to well-dispersed MW...

journal_title：Inhalation toxicology

authors： Oyabu T,Myojo T,Morimoto Y,Ogami A,Hirohashi M,Yamamoto M,Todoroki M,Mizuguchi Y,Hashiba M,Lee BW,Shimada M,Wang WN,Uchida K,Endoh S,Kobayashi N,Yamamoto K,Fujita K,Mizuno K,Inada M,Nakazato T,Nakanishi J,Tanaka

更新日期：2011-11-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...

journal_title：Inhalation toxicology

authors： Arts JH,Schijf MA,Kuper CF

更新日期：2008-08-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：CONTEXT:Cocoa-derived ingredients are used in cigarette tobacco. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from experimental cigarettes containing different added levels of cocoa-derived ingredients. MATERIALS AND METHODS:Five cocoa-derived ingredients chocolate (CH), cocoa (COC), ...

journal_title：Inhalation toxicology

authors： Coggins CR,Fisher MT,Smith DC,Oldham MJ

更新日期：2011-06-01 00:00:00

abstract：:The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...

journal_title：Inhalation toxicology

authors： Pacheco RP,Gomes JF,Miranda RM,Quintino ML

更新日期：2017-05-01 00:00:00

abstract：:Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...

journal_title：Inhalation toxicology

authors： Bruch J,Rehn B,Duval-Arnould G,Efskind J,Röderer G,Sébastian P

更新日期：2014-04-01 00:00:00

abstract：:It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individua...

journal_title：Inhalation toxicology

authors： Ghanei M,Fathi H,Mohammad MM,Aslani J,Nematizadeh F

更新日期：2004-07-01 00:00:00

abstract：:Nonhuman primates are often the animal models of choice to study the infectivity and therapy of inhaled infectious agents. Most animal models for inhaled infectious diseases use aerosol/droplets generated by an atomization technique such as a Collison nebulizer that produces particles in the size range of 1 to 3 micro...

journal_title：Inhalation toxicology

authors： Cheng YS,Irshad H,Kuehl P,Holmes TD,Sherwood R,Hobbs CH

更新日期：2008-09-01 00:00:00

abstract：:Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...

journal_title：Inhalation toxicology

authors： Lemus R,Carmines EL,Van Miert E,Coggins CR,Anskeit E,Gerstenberg B,Meisgen TJ,Schramke H,Stabbert R,Völkel H,Terpstra PM

更新日期：2007-06-01 00:00:00

abstract：:This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...

journal_title：Inhalation toxicology

authors： Chen L,Jennison BL,Yang W,Omaye ST

更新日期：2000-11-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...

journal_title：Inhalation toxicology

authors： Arts JH,Jacobs EJ,Kuper CF

更新日期：2010-02-01 00:00:00

abstract：:Acute carbon monoxide (CO) poisoning may cause cardiotoxicity. The natriuretic peptides, including atrial natriuretic peptide, brain natriuretic peptide (BNP), N-BNP, and NT-proBNP (N-terminal pro brain natriuretic peptide), are endogenous cardiac hormones that may be secreted upon myocardial stress. The aim of this s...

journal_title：Inhalation toxicology

authors： Davutoglu V,Gunay N,Kocoglu H,Gunay NE,Yildirim C,Cavdar M,Tarakcioglu M

更新日期：2006-02-01 00:00:00

abstract：:Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...

journal_title：Inhalation toxicology

authors： Cheng MF,Tsai SS,Chiu HF,Sung FC,Wu TN,Yang CY

更新日期：2009-11-01 00:00:00