Abstract:
:The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of these comparisons and the important information on other dusts (e.g., silica) that illuminate this question have necessitated inclusion of a number of papers that go beyond these nontoxic dusts.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Donaldson Kdoi
10.1080/089583700196563subject
Has Abstractpub_date
2000-01-01 00:00:00pages
121-39issue
1-2eissn
0895-8378issn
1091-7691journal_volume
12pub_type
杂志文章,评审abstract::Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902744855
更新日期:2009-11-01 00:00:00
abstract:CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.984881
更新日期:2015-01-01 00:00:00
abstract::Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370902962317
更新日期:2009-07-01 00:00:00
abstract::Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802304123
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This study characterized these elements as well as cellular and exoge...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1318985
更新日期:2017-02-01 00:00:00
abstract::A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.970783
更新日期:2014-12-01 00:00:00
abstract::Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.995387
更新日期:2015-02-01 00:00:00
abstract::Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370590922580
更新日期:2005-05-01 00:00:00
abstract::This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490443204
更新日期:2004-01-01 00:00:00
abstract::Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600563524
更新日期:2006-05-01 00:00:00
abstract::Background: High-mobility group box 1 (HMGB1) protein plays an important pathogenic role in various diseases such as pulmonary fibrosis. However, the relationship between variation of HMGB1 gene and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The objective of the study was to determine the as...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1764153
更新日期:2020-03-01 00:00:00
abstract::This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11720735
更新日期:2000-01-01 00:00:00
abstract:CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.493901
更新日期:2010-09-01 00:00:00
abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802105371
更新日期:2008-08-01 00:00:00
abstract::Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1613459
更新日期:2019-02-01 00:00:00
abstract::A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370126866
更新日期:2001-08-01 00:00:00
abstract::Epidemiological studies have reported increased morbidity in human populations following inhalation of elevated levels of urban particulate matter. These responses are especially prevalent in populations with chronic obstructive pulmonary diseases, including chronic bronchitis. Toxicological studies have reported alte...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799196781
更新日期:1999-08-01 00:00:00
abstract::Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390197254
更新日期:2003-06-01 00:00:00
abstract::Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1720867
更新日期:2020-01-01 00:00:00
abstract::Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.885099
更新日期:2014-04-01 00:00:00
abstract::With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583701753338631
更新日期:2002-01-01 00:00:00
abstract::Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500188984
更新日期:2005-11-01 00:00:00
abstract::Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701516108
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1060278
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.545841
更新日期:2011-06-01 00:00:00
abstract::It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individua...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490442421
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.592869
更新日期:2011-08-01 00:00:00
abstract::This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802409567
更新日期:2009-02-01 00:00:00
abstract::The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370902798448
更新日期:2009-08-01 00:00:00
abstract::We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370252871005
更新日期:2002-04-01 00:00:00