Time course for expression of VEGF and its receptor and regulator levels of contraction and relaxation in increased vascular permeability of lung induced by phosgene.

abstract：:It is important to conduct a risk assessment that includes hazard assessment and exposure assessment for the safe production and handling of newly developed nanomaterials. We conducted an inhalation study of a multi-wall carbon nanotube (MWCNT) as a hazard assessment. Male Wistar rats were exposed to well-dispersed MW...

journal_title：Inhalation toxicology

authors： Oyabu T,Myojo T,Morimoto Y,Ogami A,Hirohashi M,Yamamoto M,Todoroki M,Mizuguchi Y,Hashiba M,Lee BW,Shimada M,Wang WN,Uchida K,Endoh S,Kobayashi N,Yamamoto K,Fujita K,Mizuno K,Inada M,Nakazato T,Nakanishi J,Tanaka

更新日期：2011-11-01 00:00:00

abstract：:Minimally invasive approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. The potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity was investigated. Rats were expose...

journal_title：Inhalation toxicology

authors： Sellamuthu R,Umbright C,Roberts JR,Chapman R,Young SH,Richardson D,Cumpston J,McKinney W,Chen BT,Frazer D,Li S,Kashon M,Joseph P

更新日期：2012-08-01 00:00:00

abstract：:The purpose of the Enhanced Particulate Matter Surveillance Program was to provide scientifically founded information on the chemical and physical properties of dust collected over a period of approximately 1 year in Djibouti, Afghanistan (Bagram, Khowst), Qatar, United Arab Emirates, Iraq (Balad, Baghdad, Tallil, Tik...

journal_title：Inhalation toxicology

authors： Engelbrecht JP,McDonald EV,Gillies JA,Jayanty RK,Casuccio G,Gertler AW

更新日期：2009-02-01 00:00:00

abstract：:Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...

journal_title：Inhalation toxicology

authors： Borm PJ

更新日期：2002-03-01 00:00:00

abstract：:A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...

journal_title：Inhalation toxicology

authors： Koch W,Windt H,Walles M,Borlak J,Clausing P

更新日期：2001-03-01 00:00:00

abstract：:Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution particles (PM10) and ultrafine carbon black (ufCB) on the expression of CRP...

journal_title：Inhalation toxicology

authors： Ramage L,Guy K

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...

journal_title：Inhalation toxicology

authors： Walker AM,Maxim LD,Utell MJ

更新日期：2012-06-01 00:00:00

abstract：:Rats were exposed to a new graphite whisker for 4 wk by inhalation. Mass and fiber concentrations were 8.3 +/- 2.2 mg/m3 and 151.7 +/- 78.8 fibers (F)/ml, respectively, and mass median aerodynamic diameter was 3.0 micro m. Geometric mean sizes of the original whiskers were 0.86 micro m diameter and 6.8 micro m length....

journal_title：Inhalation toxicology

authors： Ishimatsu S,Hori H,Oyabu T,Tanaka I

更新日期：2003-01-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

journal_title：Inhalation toxicology

authors： Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

更新日期：2012-12-01 00:00:00

abstract：:In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume ...

journal_title：Inhalation toxicology

authors： Baan RA

更新日期：2007-01-01 00:00:00

abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...

journal_title：Inhalation toxicology

authors： Stöber W

更新日期：1999-04-01 00:00:00

abstract：:The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...

journal_title：Inhalation toxicology

authors： Pacheco RP,Gomes JF,Miranda RM,Quintino ML

更新日期：2017-05-01 00:00:00

abstract：:Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...

journal_title：Inhalation toxicology

authors： Andersen ME,Sarangapani R

更新日期：2001-05-01 00:00:00

abstract：CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...

journal_title：Inhalation toxicology

authors： Mauderly JL,Barrett EG,Gigliotti AP,McDonald JD,Reed MD,Seagrave J,Mitchell LA,Seilkop SK

更新日期：2011-05-01 00:00:00

abstract：:In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...

journal_title：Inhalation toxicology

authors： Rödelsperger K

更新日期：2004-10-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....

journal_title：Inhalation toxicology

authors： Hilpert M,Ilievski V,Coady M,Andrade-Gutierrez M,Yan B,Chillrud SN,Navas-Acien A,Kleiman NJ

更新日期：2019-01-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...

journal_title：Inhalation toxicology

authors： Arts JH,Jacobs EJ,Kuper CF

更新日期：2010-02-01 00:00:00

abstract：:The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...

journal_title：Inhalation toxicology

authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

journal_title：Inhalation toxicology

authors： Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

更新日期：2015-01-01 00:00:00

abstract：:The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. However, while the population exposed to silver nanoparticles continues to increase with ever new applications, silver nanoparticles remain a controversial research area as regards the...

journal_title：Inhalation toxicology

authors： Kim YS,Kim JS,Cho HS,Rha DS,Kim JM,Park JD,Choi BS,Lim R,Chang HK,Chung YH,Kwon IH,Jeong J,Han BS,Yu IJ

更新日期：2008-04-01 00:00:00

abstract：:The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did sever...

journal_title：Inhalation toxicology

authors： Beaupré LA,Salehi F,Zayed J,Plamondon P,L'Espérance G

更新日期：2004-04-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...

journal_title：Inhalation toxicology

authors： Coggins CR,Merski JA,Oldham MJ

更新日期：2011-06-01 00:00:00

abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...

journal_title：Inhalation toxicology

authors： Alexis NE,Lay JC,Hazucha M,Harris B,Hernandez ML,Bromberg PA,Kehrl H,Diaz-Sanchez D,Kim C,Devlin RB,Peden DB

更新日期：2010-06-01 00:00:00

abstract：:In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the "Magic Nano Glass & Ceramic" spray and "Magic Nano Bath" spray. In contrast, the previously marketed "Magic Nano" pump spray product (handheld trigger device without propell...

journal_title：Inhalation toxicology

authors： Pauluhn J,Hahn A,Spielmann H

更新日期：2008-11-01 00:00:00

abstract：CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...

journal_title：Inhalation toxicology

authors： Shohrati M,Karimzadeh I,Saburi A,Khalili H,Ghanei M

更新日期：2014-08-01 00:00:00

abstract：:We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...

journal_title：Inhalation toxicology

authors： Moolgavkar SH,Brown RC,Turim J

更新日期：2001-09-01 00:00:00

abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

journal_title：Inhalation toxicology

authors： Morris JB

更新日期：2002-06-01 00:00:00