Abstract:
:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of sources that differed primarily in overall purity and metal contaminants, were examined for their effects in vitro (toxicity and NLRP3 inflammasome activation using primary alveolar macrophages isolated from C57Bl/6 mice). In addition, in vivo exposures were conducted to determine the inflammatory and pathogenic potency. The particles produced a differential magnitude of responses, both in vivo and in vitro, that was associated most strongly with nickel contamination on the particle. Furthermore, the mechanism of action for the Ni-contaminated particles was in their ability to disrupt macrophage phagolysosomes, which resulted in NLRP3 activation and subsequent cytokine release associated with prolonged inflammation and lung pathology.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian Adoi
10.3109/08958378.2012.745633subject
Has Abstractpub_date
2012-12-01 00:00:00pages
995-1008issue
14eissn
0895-8378issn
1091-7691journal_volume
24pub_type
杂志文章abstract::The application of a proportional-integral-derivative (PID) control algorithm to an inhalation exposure system using a building automation system is described. Previous studies had utilized a control system in which concentration was monitored continuously and adjustments to the generator were made on a continuous bas...
journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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