Abstract:
:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure in a swimming pool, exhaled nitric oxide and pulmonary function were repeatedly measured in 18 children over a 1-mo period. Symptomatic children with impaired pulmonary function had higher nitric oxide levels on the day after the exposure compared to day 8 and day 28. Differences in exhaled nitric oxide were more pronounced at a higher exhalation flow compared to lower flow, suggesting peripheral rather than central airway damage. This was in accordance with the observed changes in pulmonary function. No changes in exhaled nitric oxide were seen in asymptomatic children. These data suggest that acute chlorine gas exposure results in a mild increase of exhaled nitric oxide in symptomatic children.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen Fdoi
10.1080/08958370701432157subject
Has Abstractpub_date
2007-08-01 00:00:00pages
895-8issue
10eissn
0895-8378issn
1091-7691pii
781179684journal_volume
19pub_type
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