Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VI. Gene expression in heart and lung tissue.

abstract：:Nonhuman primates are often the animal models of choice to study the infectivity and therapy of inhaled infectious agents. Most animal models for inhaled infectious diseases use aerosol/droplets generated by an atomization technique such as a Collison nebulizer that produces particles in the size range of 1 to 3 micro...

journal_title：Inhalation toxicology

authors： Cheng YS,Irshad H,Kuehl P,Holmes TD,Sherwood R,Hobbs CH

更新日期：2008-09-01 00:00:00

abstract：CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...

journal_title：Inhalation toxicology

authors： Perez CM,Hazari MS,Ledbetter AD,Haykal-Coates N,Carll AP,Cascio WE,Winsett DW,Costa DL,Farraj AK

更新日期：2015-01-01 00:00:00

abstract：:We assessed the effects of long-term inhalation of toner on the pathological changes and formation of 8-hydroxydeoxyguanosine (8-OH-Gua) in DNA in a rat model. Female Wistar rats (10 wk old) were divided evenly into a high concentration exposure group (H: 15.2 mg/m(3)), a low concentration exposure group (L: 5.5 mg/m(...

journal_title：Inhalation toxicology

authors： Morimoto Y,Kim H,Oyabu T,Hirohashi M,Nagatomo H,Ogami A,Yamato H,Obata Y,Kasai H,Higashi T,Tanaka I

更新日期：2005-12-01 00:00:00

abstract：:Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...

journal_title：Inhalation toxicology

authors： Ryan PH,LeMasters GK

更新日期：2007-01-01 00:00:00

abstract：:Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. Microbial infections have been ...

journal_title：Inhalation toxicology

authors： Nikula KJ,Green FH

更新日期：2000-01-01 00:00:00

abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...

journal_title：Inhalation toxicology

authors： Webber JS,Getman M,Ward TJ

更新日期：2006-11-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:AKR/J mice were exposed to cigarette smoke (CS) and/or lipopolysaccharide (LPS) via inhalation for 3 wk and pulmonary responses were evaluated. The objective was to explore the feasibility of coexposing LPS with cigarette smoke under a subacute exposure, as a surrogate for viral or bacterial insults, that would mimic ...

journal_title：Inhalation toxicology

authors： Lee KM,Renne RA,Harbo SJ,Clark ML,Johnson RE,Gideon KM

更新日期：2007-01-01 00:00:00

abstract：:The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...

journal_title：Inhalation toxicology

authors： Hälinen AI,Pennanen AS,Salonen RO

更新日期：2000-08-01 00:00:00

abstract：:This article addresses the importance of blood pressure as a covariate in studies of long-term associations between air quality and mortality. We focus on a cohort of about 50,000 U.S. veterans who had been diagnosed as hypertensive at some time and whose survival rates were predicted by blood pressure (BP) and ambien...

journal_title：Inhalation toxicology

authors： Lipfert FW,Perry HM Jr,Miller JP,Baty JD,Wyzga RE,Carmody SE

更新日期：2003-04-25 00:00:00

abstract：:This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...

journal_title：Inhalation toxicology

authors： Kendall M,Guntern J,Lockyer NP,Jones FH,Hutton BM,Lippmann M,Tetley TD

更新日期：2004-01-01 00:00:00

abstract：:With growing evidence of the association between daily mortality and air pollution in adults, it is important to investigate whether infants are also susceptible to the adverse health effects of ambient air pollutants. The purpose of this study is to examine the relationship between air pollution and postneonatal mort...

journal_title：Inhalation toxicology

authors： Tsai SS,Chen CC,Hsieh HJ,Chang CC,Yang CY

更新日期：2006-03-01 00:00:00

abstract：:To elucidate dose-response and other effects of diesel particles in guinea pigs chronically exposed to diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens. Guinea pigs were exposed 16 h/day, 6 days/wk, for 6, 12, 18, or 24 m...

journal_title：Inhalation toxicology

authors： Ishihara Y,Kagawa J

更新日期：2002-10-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:In the evaluation of particulate matter (PM) toxicity, one faces the challenge of identifying components that could be addressed as markers of toxicity. This study examines the use of statistical methods to determine which components present in the complex mixtures are related to toxic effects. The work is based on da...

journal_title：Inhalation toxicology

authors： Alfaro-Moreno E,Ponce-de-León S,Osornio-Vargas AR,García-Cuellar C,Martínez L,Rosas I

更新日期：2007-01-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...

journal_title：Inhalation toxicology

authors： Qin G,Meng Z

更新日期：2006-07-01 00:00:00

abstract：:This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...

journal_title：Inhalation toxicology

authors： Hsieh YL,Tsai SS,Yang CY

更新日期：2013-07-01 00:00:00

abstract：:Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to estimate tissue metabolism rates and partitioning, and to apply the model to calculate an inhalation unit risk (IUR) for chloroprene.Materials and methods: Female B6C...

journal_title：Inhalation toxicology

authors： Clewell HJ 3rd,Campbell JL,Van Landingham C,Franzen A,Yoon M,Dodd DE,Andersen ME,Gentry PR

更新日期：2019-01-01 00:00:00

abstract：:A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...

journal_title：Inhalation toxicology

authors： Koch W,Windt H,Walles M,Borlak J,Clausing P

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This study characterized these elements as well as cellular and exoge...

journal_title：Inhalation toxicology

authors： Carson JL,Zhou L,Brighton L,Mills KH,Zhou H,Jaspers I,Hazucha M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...

journal_title：Inhalation toxicology

authors： Baber O,Jang M,Barber D,Powers K

更新日期：2011-08-01 00:00:00

abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

journal_title：Inhalation toxicology

authors： Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

journal_title：Inhalation toxicology

authors： Finley BL,Benson SM,Marsh GM

更新日期：2017-03-01 00:00:00

abstract：:Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...

journal_title：Inhalation toxicology

authors： Kuempel ED,Tran CL,Castranova V,Bailer AJ

更新日期：2006-09-01 00:00:00

abstract：:Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...

journal_title：Inhalation toxicology

authors： Karataş M,Gündüzöz M,Büyükşekerci M,Özakıncı OG,Nadir Öziş T

更新日期：2019-02-01 00:00:00

abstract：:Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotox...

journal_title：Inhalation toxicology

authors： van Maanen JM,Borm PJ,Knaapen A,van Herwijnen M,Schilderman PA,Smith KR,Aust AE,Tomatis M,Fubini B

更新日期：1999-12-01 00:00:00

abstract：:Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...

journal_title：Inhalation toxicology

authors： Park JD,Chung YH,Kim CY,Ha CS,Yang SO,Khang HS,Yu IK,Cheong HK,Lee JS,Song CW,Kwon IH,Han JH,Sung JH,Heo JD,Choi BS,Im R,Jeong J,Yu IJ

更新日期：2007-09-01 00:00:00

abstract：:The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...

journal_title：Inhalation toxicology

authors： Wegesser TC,Franzi LM,Mitloehner FM,Eiguren-Fernandez A,Last JA

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

journal_title：Inhalation toxicology

authors： Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

更新日期：2015-01-01 00:00:00