Abstract:
:Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotoxicity in rat lung epithelial (RLE) cells by different coal fly ashes (CFA) that contain both quartz and iron. Seven samples of CFA with different particle size and quartz content (up to 14.1%) were tested along with silica (alpha-quartz), ground coal, and coal mine dust (respirable) as positive control particles, and fine TiO(2) (anatase) as a negative control. Five test samples were pulverized fuel ashes (PFA), two samples were coal gasification (SCG) ashes (quartz content <0.1%), and one sample was a ground coal. No marked differences between SCG and PFA fly ashes were observed, and toxicity did not correlate with physicochemical characteristics or effect parameters. Stable surface radicals were only detected in the reference particles silica and coal mine dust, but not in CFA. On the other hand, hydroxyl radical generation by all fly ashes was observed in the presence of hydrogen peroxide, which was positively correlated with iron mobilization and inhibited by deferoxamine, but not correlated with iron or quartz content. Also a relationship between acellular hydroxyl radical generation and oxidative DNA damage in RLE cells by CFA was observed. Differences in hydroxyl radical generation and oxidative damage by the CFA were not related to iron and quartz content, but the respirable ashes (MAT023, 38, and 41) showed a very extensive level of hydroxyl radical generation in comparison to nonrespirable fly ashes and respirable references. This radical generation was clearly related to the iron mobilization from these particles. In conclusion, the mechanisms by which CFA and the positive references (silica, coal mine dust) affect rat lung epithelial cells seem to be different, and the data suggest that quartz in CFA does not act the same as quartz in silica or coal mine dust. On the other hand, the results indicate an important role for size and iron release in generation and subsequent effects of reactive oxygen species caused by CFA.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
van Maanen JM,Borm PJ,Knaapen A,van Herwijnen M,Schilderman PA,Smith KR,Aust AE,Tomatis M,Fubini Bdoi
10.1080/089583799196628subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1123-41issue
12eissn
0895-8378issn
1091-7691journal_volume
11pub_type
杂志文章abstract::In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701497903
更新日期:2007-01-01 00:00:00
abstract::Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802304123
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.683892
更新日期:2012-06-01 00:00:00
abstract:CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903349365
更新日期:2010-03-01 00:00:00
abstract::Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701495998
更新日期:2007-01-01 00:00:00
abstract::Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463217
更新日期:2000-01-01 00:00:00
abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1080772
更新日期:2015-01-01 00:00:00
abstract::In the evaluation of particulate matter (PM) toxicity, one faces the challenge of identifying components that could be addressed as markers of toxicity. This study examines the use of statistical methods to determine which components present in the complex mixtures are related to toxic effects. The work is based on da...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701492987
更新日期:2007-01-01 00:00:00
abstract::Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. To explore the exposu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.636086
更新日期:2012-01-01 00:00:00
abstract::Because of the interest attendant to establishing an 8-h ozone (O(3)) federal air quality standard, acute pulmonary function responses to prolonged (6.6 to 8 h) O(3) exposure between 0.08 and 0. 24 ppm have been examined in chamber studies. Given time constraints for O(3) concentration changes in room-sized chambers a...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583700196167
更新日期:2000-04-01 00:00:00
abstract::The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902934894
更新日期:2010-02-01 00:00:00
abstract:CONTEXT:Eleven carbohydrates and natural product ingredients were added individually to experimental cigarettes. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from these experimental cigarettes to matched control cigarettes without test ingredients. MATERIALS AND METHODS:Smoke fraction...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.545085
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1809572
更新日期:2020-07-01 00:00:00
abstract::An original mathematical model describing particle diffusion in human nasal passages is presented. A unique feature of the model is that it combines effects of both turbulent and laminar flows. To account for turbulence, concentration equations written in cylindrical coordinates are first simplified by a scaling techn...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370304458
更新日期:2003-04-11 00:00:00
abstract::Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370290084908
更新日期:2002-12-01 00:00:00
abstract::Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.695815
更新日期:2012-07-01 00:00:00
abstract::Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370590885672
更新日期:2005-01-01 00:00:00
abstract::NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to those of lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701821219
更新日期:2008-01-01 00:00:00
abstract::Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390197254
更新日期:2003-06-01 00:00:00
abstract::Methylhexahydrophthalic anhydride (MHHPA) is a reactive, low molecular weight chemical used in products such as plastics, paints, and electronic components. Exposure to MHHPA may lead to work-related airway diseases such as rhinitis, conjunctivitis, and asthma. Twelve subjects employed at a plant manufacturing electri...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802715997
更新日期:2009-10-01 00:00:00
abstract::Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the phenomenon of lung overload and the implications, if any, of such studies for workplace dust exposure standards. The dosimetry of inhaled particles differs among...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463250
更新日期:2000-01-01 00:00:00
abstract::Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600747887
更新日期:2006-09-01 00:00:00
abstract::Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1076910
更新日期:2015-01-01 00:00:00
abstract::It is important to conduct a risk assessment that includes hazard assessment and exposure assessment for the safe production and handling of newly developed nanomaterials. We conducted an inhalation study of a multi-wall carbon nanotube (MWCNT) as a hazard assessment. Male Wistar rats were exposed to well-dispersed MW...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.608096
更新日期:2011-11-01 00:00:00
abstract::In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle prope...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701866313
更新日期:2008-02-01 00:00:00
abstract::This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11720735
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.844749
更新日期:2013-11-01 00:00:00
abstract::Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802015091
更新日期:2008-07-01 00:00:00
abstract::Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
abstract::Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.584919
更新日期:2011-07-01 00:00:00