Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area.

abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...

journal_title：Inhalation toxicology

authors： More SL,Thornton SA,Maskrey JR,Sharma A,de Gandiaga E,Cheng TJ,Fung ES,Bernal AJ,Madl AK

更新日期：2020-01-01 00:00:00

abstract：:Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...

journal_title：Inhalation toxicology

authors： Oldham MJ,Robinson RJ

更新日期：2006-09-01 00:00:00

abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...

journal_title：Inhalation toxicology

authors： Grahame T,Schlesinger R

更新日期：2005-01-01 00:00:00

abstract：:The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...

journal_title：Inhalation toxicology

authors： González-Guevara E,Martínez-Lazcano JC,Custodio V,Hernández-Cerón M,Rubio C,Paz C

更新日期：2014-07-01 00:00:00

abstract：:Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi...

journal_title：Inhalation toxicology

authors： McKinney W,Chen B,Frazer D

更新日期：2009-10-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...

journal_title：Inhalation toxicology

authors： Mauderly JL,Barrett EG,Gigliotti AP,McDonald JD,Reed MD,Seagrave J,Mitchell LA,Seilkop SK

更新日期：2011-05-01 00:00:00

abstract：:Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

journal_title：Inhalation toxicology

authors： Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

更新日期：2015-02-01 00:00:00

abstract：:Studies have shown associations between acute ambient particulate matter (PM) levels and increases in morbidity and mortality from cardiovascular diseases. We have previously reported in 24 healthy adults that exposure to concentrated ambient particles plus ozone (CAP + O(3)) caused a mean decrease of 0.09 mm in brach...

journal_title：Inhalation toxicology

authors： Urch B,Brook JR,Wasserstein D,Brook RD,Rajagopalan S,Corey P,Silverman F

更新日期：2004-06-01 00:00:00

abstract：:During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...

journal_title：Inhalation toxicology

authors： Chate D,Beig G,Satpute T,Sahu SK,Ali K,Parkhi N,Ghude S

更新日期：2013-05-01 00:00:00

abstract：:Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...

journal_title：Inhalation toxicology

authors： Cullen RT,Miller BG,Clark S,Davis JM

更新日期：2002-07-01 00:00:00

abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...

journal_title：Inhalation toxicology

authors： Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen F

更新日期：2007-08-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：:A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...

journal_title：Inhalation toxicology

authors： Buschmann J,Bartsch W,Dasenbrock C,Fuhst R,Pohlmann G,Preiss A,Berger-Preiss E

更新日期：2001-08-01 00:00:00

abstract：:A low-cutoff, high-volume conventional impactor has been designed. This sampler uses a slit-shaped acceleration jet and operates at 1100 L/min. The impaction substrate is polyurethane foam (PUF). The impactor collection efficiency was characterized using polydisperse particles, and the 50% size cutoff point was 0.12 ¡...

journal_title：Inhalation toxicology

authors： Kavouras IG,Ferguson ST,Wolfson JM,Koutrakis P

更新日期：2000-01-01 00:00:00

abstract：:Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...

journal_title：Inhalation toxicology

authors： Calderón-Garcidueñas L,Villarreal-Calderon R,Valencia-Salazar G,Henríquez-Roldán C,Gutiérrez-Castrellón P,Torres-Jardón R,Osnaya-Brizuela N,Romero L,Torres-Jardón R,Solt A,Reed W

更新日期：2008-03-01 00:00:00

abstract：:The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...

journal_title：Inhalation toxicology

authors： Samuelsen M,Cecilie Nygaard U,Løvik M

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science...

journal_title：Inhalation toxicology

authors： Hudda N,Durant JL,Nemeth A,Mann P,Petitto J,Brugge D,Nephew BC

更新日期：2019-08-01 00:00:00

abstract：CONTEXT:Eleven carbohydrates and natural product ingredients were added individually to experimental cigarettes. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from these experimental cigarettes to matched control cigarettes without test ingredients. MATERIALS AND METHODS:Smoke fraction...

journal_title：Inhalation toxicology

authors： Coggins CR,Wagner KA,Werley MS,Oldham MJ

更新日期：2011-06-01 00:00:00

abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

journal_title：Inhalation toxicology

authors： Gunnison A,Chen LC

更新日期：2005-04-01 00:00:00

abstract：:Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...

journal_title：Inhalation toxicology

authors： Johns DO,Linn WS

更新日期：2011-01-01 00:00:00

abstract：:This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...

journal_title：Inhalation toxicology

authors： Kendall M,Guntern J,Lockyer NP,Jones FH,Hutton BM,Lippmann M,Tetley TD

更新日期：2004-01-01 00:00:00

abstract：CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

journal_title：Inhalation toxicology

authors： Seagrave J,Weber WM,Grotendorst GR

更新日期：2010-09-01 00:00:00

abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...

journal_title：Inhalation toxicology

authors： Bennett WD,Zeman KL

更新日期：2005-11-01 00:00:00

abstract：:Cigarette smoke exposures in mice have been conducted under various exposure conditions using different strains as animal models of smoke-related diseases. We exposed cigarette smoke to two strains of mice [C57BL/6J (C57) and AKR/J (AKR)] under two different exposure regimens (1 h or 4 h/day) at equivalent daily expos...

journal_title：Inhalation toxicology

authors： Tsuji H,Fujimoto H,Matsuura D,Nishino T,Lee KM,Renne R,Yoshimura H

更新日期：2011-08-01 00:00:00

abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...

journal_title：Inhalation toxicology

authors： Hei TK,Xu A,Louie D,Zhao YL

更新日期：2000-01-01 00:00:00

abstract：:The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated response to acute ozone exposure dependent on the type and severity of disea...

journal_title：Inhalation toxicology

authors： Kodavanti UP,Ledbetter AD,Thomas RF,Richards JE,Ward WO,Schladweiler MC,Costa DL

更新日期：2015-01-01 00:00:00

abstract：:Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...

journal_title：Inhalation toxicology

authors： Park JD,Chung YH,Kim CY,Ha CS,Yang SO,Khang HS,Yu IK,Cheong HK,Lee JS,Song CW,Kwon IH,Han JH,Sung JH,Heo JD,Choi BS,Im R,Jeong J,Yu IJ

更新日期：2007-09-01 00:00:00

abstract：:We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...

journal_title：Inhalation toxicology

authors： Monn C,Fendt R,Koller T

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...

journal_title：Inhalation toxicology

authors： Martin BL,Thompson LC,Kim YH,Snow SJ,Schladweiler MC,Phillips P,Harmon M,King C,Richards J,George I,W Kyle Martin,Haykal-Coates N,Gilmour MI,Kodavanti UP,Hazari MS,Farraj AK

更新日期：2020-07-01 00:00:00