Abstract:
:Wistar rats were exposed for 24 mo to diesel emissions containing a low (0.2 ppm, 0.21 mg/m(3)), medium (1.04 ppm, 1.18 mg/m(3)), or high (2.96 ppm, 3.05 mg/m(3)) concentration of NO(2) and particles, or diesel emissions containing a medium (1.12 ppm, 0.01 mg/m(3)) concentration of NO(2) without particles. At 6-mo intervals during the exposure period, rats were autopsied, and their lungs were prepared for light- and electron-microscopic examination. Morphological evaluations included examination for hyperplasia of airway goblet cells, shift in the types of glycoprotein of intracellular mucus granules in goblet cells, infiltration of inflammatory cells in the airways, enlargement of the cross-sectional area of an alveolus as a parameter of air space enlargement, and development of alveolar holes, which is considered to be an early hallmark of alveolar destruction. The number of goblet cells with acid-form mucus granules increased with the exposure concentration and time; however, goblet cells did not show any hyperplastic changes. Furthermore, inflammatory cells such as alveolar macrophages, mast cells, plasma cells, neutrophils, and lymphocytes infiltrated the airways and the alveoli, and showed some cell-to-cell contact. Although no significant enlargement of the air space of the lungs was seen in any exposure group, the number of alveolar holes was significantly higher in the high-concentration group in comparison with the control group at each exposure time, and also increased in other exposure groups, even in the low-concentration group at certain exposure times. Morphological changes in the lungs were mild even in the animals exposed to the highest levels of diesel emissions for 24 mo. Elimination of particles from diesel emissions led to reduced morphological changes such as a decreased shift in the types of glycoprotein of mucus granules in goblet cells, decreased infiltration of inflammatory cells in the lungs, and reduced anthracosis.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Kato A,Nagai A,Kagawa Jdoi
10.1080/089583700402879subject
Has Abstractpub_date
2000-06-01 00:00:00pages
469-90issue
6eissn
0895-8378issn
1091-7691journal_volume
12pub_type
杂志文章abstract::The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. However, while the population exposed to silver nanoparticles continues to increase with ever new applications, silver nanoparticles remain a controversial research area as regards the...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701874663
更新日期:2008-04-01 00:00:00
abstract::Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463207
更新日期:2000-01-01 00:00:00
abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799197096
更新日期:1999-04-01 00:00:00
abstract::Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1342719
更新日期:2017-05-01 00:00:00
abstract::This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490443204
更新日期:2004-01-01 00:00:00
abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.695815
更新日期:2012-07-01 00:00:00
abstract::The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.922648
更新日期:2014-07-01 00:00:00
abstract::A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390249120
更新日期:2003-12-01 00:00:00
abstract::In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701497903
更新日期:2007-01-01 00:00:00
abstract::The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958371003596587
更新日期:2010-06-01 00:00:00
abstract::Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.907587
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:Air pollution causes respiratory symptoms and pulmonary disease. Airway inflammation may be involved in the mechanism also for cardiovascular disease. Wood smoke is a significant contributor to air pollution, with complex and varying composition. We examined airway effects of two kinds of wood smoke in a c...
journal_title:Inhalation toxicology
pub_type: 临床试验,杂志文章
doi:10.3109/08958378.2011.633281
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1060278
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1385113
更新日期:2017-07-01 00:00:00
abstract::Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1613459
更新日期:2019-02-01 00:00:00
abstract::With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583701753338631
更新日期:2002-01-01 00:00:00
abstract::Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant increase in polymorphonuclear leukocytes (PMN), total protein and albumin ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.751143
更新日期:2013-01-01 00:00:00
abstract::This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.897400
更新日期:2014-05-01 00:00:00
abstract::This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583701753210371
更新日期:2001-11-01 00:00:00
abstract::We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370252871005
更新日期:2002-04-01 00:00:00
abstract::The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050085129
更新日期:2000-08-01 00:00:00
abstract::Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370290084584
更新日期:2002-07-01 00:00:00
abstract::Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. Microbial infections have been ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583700750019549
更新日期:2000-01-01 00:00:00
abstract::This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.804609
更新日期:2013-07-01 00:00:00
abstract::We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583701316941294
更新日期:2001-09-01 00:00:00
abstract::The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) loaded with sildenafil. The SLNs were tested as a new drug delivery system (DDS) for the inhalable treatment of pulmonary hypertension in human lungs. Solubility of sildenafil in SLN lipid matrix (30:70 phospholipid:...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.810315
更新日期:2013-08-01 00:00:00
abstract::Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701432157
更新日期:2007-08-01 00:00:00
abstract::Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370590922580
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1809572
更新日期:2020-07-01 00:00:00