Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid.

abstract：:In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle prope...

journal_title：Inhalation toxicology

authors： Maier KL,Alessandrini F,Beck-Speier I,Hofer TP,Diabaté S,Bitterle E,Stöger T,Jakob T,Behrendt H,Horsch M,Beckers J,Ziesenis A,Hültner L,Frankenberger M,Krauss-Etschmann S,Schulz H

更新日期：2008-02-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...

journal_title：Inhalation toxicology

authors： Widmeier S,Bernard A,Tschopp A,Jeggli S,Dumont X,Hilfiker S,Oppliger A,Hotz P

更新日期：2007-04-01 00:00:00

abstract：:Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...

journal_title：Inhalation toxicology

authors： Warman M,Tiomkin E,Huszar M,Halperin D,Asher I,Cohen O

更新日期：2020-05-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

journal_title：Inhalation toxicology

authors： Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

更新日期：2012-12-01 00:00:00

abstract：:Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

journal_title：Inhalation toxicology

authors： Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

更新日期：2006-05-01 00:00:00

abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-11-01 00:00:00

abstract：:Because of the interest attendant to establishing an 8-h ozone (O(3)) federal air quality standard, acute pulmonary function responses to prolonged (6.6 to 8 h) O(3) exposure between 0.08 and 0. 24 ppm have been examined in chamber studies. Given time constraints for O(3) concentration changes in room-sized chambers a...

journal_title：Inhalation toxicology

authors： Adams WC

更新日期：2000-04-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

journal_title：Inhalation toxicology

authors： Morris JB

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...

journal_title：Inhalation toxicology

authors： Yıldırım F,Çevik Y,Emektar E,Çorbacıoğlu ŞK,Katırcı Y

更新日期：2016-10-01 00:00:00

abstract：:The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...

journal_title：Inhalation toxicology

authors： Webber JS,Getman M,Ward TJ

更新日期：2006-11-01 00:00:00

abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...

journal_title：Inhalation toxicology

authors： Grahame T,Schlesinger R

更新日期：2005-01-01 00:00:00

abstract：:Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...

journal_title：Inhalation toxicology

authors： Gordon T,Gerber H,Fang CP,Chen LC

更新日期：1999-01-01 00:00:00

abstract：:Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...

journal_title：Inhalation toxicology

authors： Daigle CC,Chalupa DC,Gibb FR,Morrow PE,Oberdörster G,Utell MJ,Frampton MW

更新日期：2003-05-01 00:00:00

abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...

journal_title：Inhalation toxicology

authors： Graham JR,Wright BS,Rezk PE,Gordon RK,Sciuto AM,Nambiar MP

更新日期：2006-06-01 00:00:00

abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...

journal_title：Inhalation toxicology

authors： DeLorme MP,Himmelstein MW,Kemper RA,Kegelman TA,Gargas ML,Kinzell JH

更新日期：2009-05-01 00:00:00

abstract：:Propylene glycol mono-t-butyl ether (PGMBE) is a widely used solvent in industry and in consumer products, posing a potential for human exposure via inhalation or dermal routes. Toxicokinetic studies were conducted on F344/N rats and B6C3F1 mice of both sexes to evaluate single or repeated dose, species, and/or sex di...

journal_title：Inhalation toxicology

authors： Dill J,Fuciarelli A,Lee K,Mellinger K,Burka L,Roycroft J

更新日期：2004-05-01 00:00:00

abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...

journal_title：Inhalation toxicology

authors： Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen F

更新日期：2007-08-01 00:00:00

abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...

journal_title：Inhalation toxicology

authors： Bennett WD,Zeman KL

更新日期：2005-11-01 00:00:00

abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

journal_title：Inhalation toxicology

authors： Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

更新日期：2020-02-01 00:00:00

abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

journal_title：Inhalation toxicology

authors： Gunnison A,Chen LC

更新日期：2005-04-01 00:00:00

abstract：:Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

journal_title：Inhalation toxicology

authors： Maxim LD,McConnell EE

更新日期：2005-08-01 00:00:00

abstract：:Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. Microbial infections have been ...

journal_title：Inhalation toxicology

authors： Nikula KJ,Green FH

更新日期：2000-01-01 00:00:00

abstract：:To elucidate dose-response and other effects of diesel particles in guinea pigs chronically exposed to diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens. Guinea pigs were exposed 16 h/day, 6 days/wk, for 6, 12, 18, or 24 m...

journal_title：Inhalation toxicology

authors： Ishihara Y,Kagawa J

更新日期：2002-10-01 00:00:00

abstract：:Fine particulate matter (PM(2.5)) is associated with respiratory effects, and asthmatic children are especially sensitive. Preliminary evidence suggests that combustion-derived particles play an important role. Our objective was to evaluate effect estimates from different PM(2.5) exposure metrics in relation to airway...

journal_title：Inhalation toxicology

authors： Allen RW,Mar T,Koenig J,Liu LJ,Gould T,Simpson C,Larson T

更新日期：2008-02-01 00:00:00

abstract：:Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...

journal_title：Inhalation toxicology

authors： Katre A,Ballinger C,Akhter H,Fanucchi M,Kim DK,Postlethwait E,Liu RM

更新日期：2011-07-01 00:00:00

abstract：:This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...

journal_title：Inhalation toxicology

authors： Kendall M,Guntern J,Lockyer NP,Jones FH,Hutton BM,Lippmann M,Tetley TD

更新日期：2004-01-01 00:00:00

abstract：:Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...

journal_title：Inhalation toxicology

authors： Kuempel ED,Tran CL,Castranova V,Bailer AJ

更新日期：2006-09-01 00:00:00

abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...

journal_title：Inhalation toxicology

authors： Stöber W

更新日期：1999-04-01 00:00:00