听力与言语-语言病理学

行为科学

医学伦理学

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  • Novel therapies for mucopolysaccharidosis type III.

    abstract::Mucopolysaccharidosis type III (MPS III) or Sanfilippo disease is an orphan inherited lysosomal storage disease and one of the most common MPS subtypes. The classical presentation is an infantile-onset neurodegenerative disease characterised by intellectual regression, behavioural and sleep disturbances, loss of ambul...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12316

    authors: Seker Yilmaz B,Davison J,Jones SA,Baruteau J

    更新日期:2021-01-01 00:00:00

  • Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: A review.

    abstract::Glycogen storage disease type Ia (GSD-Ia) is an inherited metabolic disease caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) which plays a critical role in blood glucose homeostasis by catalyzing the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of glycogenol...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12267

    authors: Cho JH,Weinstein DA,Lee YM

    更新日期:2021-01-01 00:00:00

  • International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.

    abstract::Phosphoglucomutase 1 (PGM1) deficiency is a rare genetic disorder that affects glycogen metabolism, glycolysis, and protein glycosylation. Previously known as GSD XIV, it was recently reclassified as a congenital disorder of glycosylation, PGM1-CDG. PGM1-CDG usually manifests as a multisystem disease. Most patients pr...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12286

    authors: Altassan R,Radenkovic S,Edmondson AC,Barone R,Brasil S,Cechova A,Coman D,Donoghue S,Falkenstein K,Ferreira V,Ferreira C,Fiumara A,Francisco R,Freeze H,Grunewald S,Honzik T,Jaeken J,Krasnewich D,Lam C,Lee J,Lefeber

    更新日期:2021-01-01 00:00:00

  • Quantitative retrospective natural history modeling for orphan drug development.

    abstract::The natural history of most rare diseases is incompletely understood and usually relies on studies with low level of evidence. Consistent with the goals for future research of rare disease research set by the International Rare Diseases Research Consortium in 2017, the purpose of this paper is to review the recently d...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12304

    authors: Garbade SF,Zielonka M,Komatsuzaki S,Kölker S,Hoffmann GF,Hinderhofer K,Mountford WK,Mengel E,Sláma T,Mechler K,Ries M

    更新日期:2021-01-01 00:00:00

  • Delineating the clinical spectrum of isolated methylmalonic acidurias: cblA and mut.

    abstract:INTRODUCTION:Long-term outcome is postulated to be different in isolated methylmalonic aciduria caused by mutations in the MMAA gene (cblA type) compared with methylmalonyl-CoA mutase deficiency (mut), but case definition was previously difficult. METHOD:Cross-sectional analysis of data from the European Registry and ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12297

    authors: Hörster F,Tuncel AT,Gleich F,Plessl T,Froese SD,Garbade SF,Kölker S,Baumgartner MR,Additional Contributors from E-IMD.

    更新日期:2021-01-01 00:00:00

  • Regulatory environment for novel therapeutic development in mitochondrial diseases.

    abstract::At present, there is just one approved therapy for patients with mitochondrial diseases in Europe, another in Japan, and none in the United States. These facts reveal an important and significant unmet need for approved therapies for these debilitating and often fatal disorders. To fill this need, it is critical for c...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12353

    authors: Hirano M,Berardo A,Barca E,Emmanuele V,Quinzii C,Simpson CV,Engelstad K,Rosales XQ,Thompson JLP

    更新日期:2020-12-24 00:00:00

  • The potential of dietary treatment in patients with glycogen storage disease type IV.

    abstract::There is paucity of literature on dietary treatment in glycogen storage disease (GSD) type IV and formal guidelines are not available. Traditionally, liver transplantation was considered the only treatment option for GSD IV. In light of the success of dietary treatment for the other hepatic forms of GSD, we have initi...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12339

    authors: Derks TGJ,Peeks F,de Boer F,Fokkert-Wilts M,van der Doef HPJ,van den Heuvel MC,Szymańska E,Rokicki D,Ryan PT,Weinstein DA

    更新日期:2020-12-17 00:00:00

  • Disturbed brain ether lipid metabolism and histology in Sjögren-Larsson syndrome.

    abstract::Sjögren-Larsson syndrome (SLS) is a rare neurometabolic syndrome caused by deficient fatty aldehyde dehydrogenase. Patients exhibit intellectual disability, spastic paraplegia, and ichthyosis. The accumulation of fatty alcohols and fatty aldehydes has been demonstrated in plasma and skin but never in brain. Brain magn...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12275

    authors: Staps P,Rizzo WB,Vaz FM,Bugiani M,Giera M,Heijs B,van Kampen AHC,Pras-Raves ML,Breur M,Groen A,Ferdinandusse S,van der Graaf M,Van Goethem G,Lammens M,Wevers RA,Willemsen MAAP

    更新日期:2020-11-01 00:00:00

  • Long term outcome of MPI-CDG patients on D-mannose therapy.

    abstract::Mannose phosphate isomerase MPI-CDG (formerly CDG-1b) is a potentially fatal inherited metabolic disease which is readily treatable with oral D-mannose. We retrospectively reviewed long-term outcomes of patients with MPI-CDG, all but one of whom were treated with D-mannose. Clinical, biological, and histological data ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12289

    authors: Girard M,Douillard C,Debray D,Lacaille F,Schiff M,Vuillaumier-Barrot S,Dupré T,Fabre M,Damaj L,Kuster A,Torre S,Mention K,McLin V,Dobbelaere D,Borgel D,Bauchard E,Seta N,Bruneel A,De Lonlay P

    更新日期:2020-11-01 00:00:00

  • Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.

    abstract::Glutaric aciduria type 1 (GA1) is an inborn error of lysine degradation characterized by acute encephalopathy that is caused by toxic accumulation of lysine degradation intermediates. We investigated the efficacy of substrate reduction through inhibition of 2-aminoadipic semialdehyde synthase (AASS), an enzyme upstrea...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12276

    authors: Leandro J,Dodatko T,DeVita RJ,Chen H,Stauffer B,Yu C,Houten SM

    更新日期:2020-11-01 00:00:00

  • Nitisinone causes acquired tyrosinosis in alkaptonuria.

    abstract::For over two decades, nitisinone (NTBC) has been successfully used to manipulate the tyrosine degradation pathway and save the lives of many children with hereditary tyrosinaemia type 1. More recently, NTBC has been used to halt homogentisic acid accumulation in alkaptonuria (AKU) with evidence suggesting its efficacy...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12229

    authors: Khedr M,Cooper MS,Hughes AT,Milan AM,Davison AS,Norman BP,Sutherland H,Jarvis JC,Fitzgerald R,Markinson L,Psarelli EE,Ghane P,Deutz NEP,Gallagher JA,Ranganath LR

    更新日期:2020-09-01 00:00:00

  • Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.

    abstract::The transmembrane domain recognition complex (TRC) targets cytoplasmic C-terminal tail-anchored (TA) proteins to their respective membranes in the endoplasmic reticulum (ER), Golgi, and mitochondria. It is composed of three proteins, GET4, BAG6, and GET5. We identified an individual with compound heterozygous missense...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12249

    authors: Tambe MA,Ng BG,Shimada S,Wolfe LA,Adams DR,Undiagnosed Diseases Network.,Gahl WA,Bamshad MJ,Nickerson DA,Malicdan MCV,Freeze HH

    更新日期:2020-09-01 00:00:00

  • LC-MS/MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies.

    abstract::Rapid diagnosis and early specific treatment of metabolic epilepsies due to inborn errors of metabolism (IEMs) is crucial to avoid irreversible sequalae. Nowadays, besides the profile analysis of amino- and organic acids, a range of additional targeted assays is used for the selective screening of those diseases. This...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12244

    authors: Mathis D,Beese K,Rüegg C,Plecko B,Hersberger M

    更新日期:2020-09-01 00:00:00

  • Titrating a modified ketogenic diet for patients with McArdle disease: A pilot study.

    abstract::Glycogen storage disease type V (GSDV) is a rare inborn error of carbohydrate metabolism. Patients present with exercise intolerance due to blocked glycogen breakdown in skeletal muscle. Introducing alternative fuel substrates, such as ketone bodies (KBs), could potentially alleviate muscle symptoms. This pilot study ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12223

    authors: Løkken N,Hansen KK,Storgaard JH,Ørngreen MC,Quinlivan R,Vissing J

    更新日期:2020-07-01 00:00:00

  • Misdiagnosis of CTX due to propofol: The interference of total intravenous propofol anaesthesia with bile acid profiling.

    abstract:BACKGROUND:Cerebrotendinous xanthomatosis (CTX) is a rare genetic disorder, characterised by chronic diarrhoea, xanthomas, cataracts, and neurological deterioration. CTX is caused by CYP27A1 deficiency, which leads to abnormal cholesterol and bile acid metabolism. Urinary bile acid profiling (increased m/z 627: glucuro...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12219

    authors: Claesen JLA,Koomen E,Schene IF,Jans JJM,Mast N,Pikuleva IA,van der Ham M,de Sain-van der Velden MGM,Fuchs SA

    更新日期:2020-07-01 00:00:00

  • Pharmacokinetics and distribution of 2-hydroxypropyl-β-cyclodextrin following a single intrathecal dose to cats.

    abstract::2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is an experimental therapy for Niemann-Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, reduced Purkinje cell death, and increased lifespan in npc1-/- mice and NPC1 cats. In this study, tissue distribution was investigated in normal cats that...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12189

    authors: Kao ML,Stellar S,Solon E,Lordi A,Kasica N,Swain G,Bagel JH,Gurda BL,Vite CH

    更新日期:2020-05-01 00:00:00

  • Transaldolase haploinsufficiency in subjects with acetaminophen-induced liver failure.

    abstract::Transaldolase (TAL) is an enzyme in the pentose phosphate pathway (PPP) that generates NADPH for protection against oxidative stress. While deficiency of other PPP enzymes, such as transketolase (TKT), are incompatible with mammalian cell survival, mice lacking TAL are viable and develop progressive liver disease attr...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12197

    authors: Oaks Z,Jimah J,Grossman CC,Beckford M,Kelly R,Banerjee S,Niland B,Miklossy G,Kuloglu Z,Kansu A,Lee W,Szonyi L,Banki K,Perl A

    更新日期:2020-05-01 00:00:00

  • Tetrahydrobiopterin treatment in phenylketonuria: A repurposing approach.

    abstract::In phenylketonuria (PKU) patients, early diagnosis by neonatal screening and immediate institution of a phenylalanine-restricted diet can prevent severe intellectual impairment. Nevertheless, outcome remains suboptimal in some patients asking for additional treatment strategies. Tetrahydrobiopterin (BH4 ) could be one...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12151

    authors: Evers RAF,van Vliet D,van Spronsen FJ

    更新日期:2020-03-01 00:00:00

  • Recent advances in understanding the molecular genetic basis of mitochondrial disease.

    abstract::Mitochondrial disease is hugely diverse with respect to associated clinical presentations and underlying genetic causes, with pathogenic variants in over 300 disease genes currently described. Approximately half of these have been discovered in the last decade due to the increasingly widespread application of next gen...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12104

    authors: Thompson K,Collier JJ,Glasgow RIC,Robertson FM,Pyle A,Blakely EL,Alston CL,Oláhová M,McFarland R,Taylor RW

    更新日期:2020-01-01 00:00:00

  • Toward understanding tissue-specific symptoms in dolichol-phosphate-mannose synthesis disorders; insight from DPM3-CDG.

    abstract::The congenital disorders of glycosylation (CDG) are inborn errors of metabolism with a great genetic heterogeneity. Most CDG are caused by defects in the N-glycan biosynthesis, leading to multisystem phenotypes. However, the occurrence of tissue-restricted clinical symptoms in the various defects in dolichol-phosphate...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12095

    authors: van Tol W,Michelakakis H,Georgiadou E,van den Bergh P,Moraitou M,Papadimas GK,Papadopoulos C,Huijben K,Alsady M,Willemsen MA,Lefeber DJ

    更新日期:2019-09-01 00:00:00

  • Management of bone disease in cystinosis: Statement from an international conference.

    abstract::Cystinosis is an autosomal recessive storage disease due to impaired transport of cystine out of lysosomes. Since the accumulation of intracellular cystine affects all organs and tissues, the management of cystinosis requires a specialized multidisciplinary team consisting of pediatricians, nephrologists, nutritionist...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12134

    authors: Hohenfellner K,Rauch F,Ariceta G,Awan A,Bacchetta J,Bergmann C,Bechtold S,Cassidy N,Deschenes G,Elenberg E,Gahl WA,Greil O,Harms E,Herzig N,Hoppe B,Koeppl C,Lewis MA,Levtchenko E,Nesterova G,Santos F,Schlingmann K

    更新日期:2019-09-01 00:00:00

  • Allogeneic hematopoietic cell transplantation in Farber disease.

    abstract:BACKGROUND:Farber disease (FD) is a rare, lysosomal storage disorder caused by deficient acid ceramidase activity. FD has long been considered a fatal disorder with death in the first three decades of life resulting either from respiratory insufficiency as a consequence of airway involvement or from progressive neurode...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12043

    authors: Ehlert K,Levade T,Di Rocco M,Lanino E,Albert MH,Führer M,Jarisch A,Güngör T,Ayuk F,Vormoor J

    更新日期:2019-03-01 00:00:00

  • The decision to discontinue screening for carnitine uptake disorder in New Zealand.

    abstract::When screening for carnitine uptake disorder (CUD), the New Zealand (NZ) newborn screening (NBS) service identified infants as screen-positive if they had initial and repeat free carnitine (C0) levels of less than 5.0 μmol/L. Since 2006, the NBS service has identified two infants with biochemical and genetic features ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1002/jimd.12030

    authors: Wilson C,Knoll D,de Hora M,Kyle C,Glamuzina E,Webster D

    更新日期:2019-01-01 00:00:00

  • Keeping an eye on congenital disorders of O-glycosylation: A systematic literature review.

    abstract::Congenital disorders of glycosylation (CDG) are a rapidly growing family comprising >100 genetic diseases. Some 25 CDG are pure O-glycosylation defects. Even among this CDG subgroup, phenotypic diversity is broad, ranging from mild to severe poly-organ/system dysfunction. Ophthalmic manifestations are present in 60% o...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1002/jimd.12025

    authors: Francisco R,Pascoal C,Marques-da-Silva D,Morava E,Gole GA,Coman D,Jaeken J,Dos Reis Ferreira V

    更新日期:2019-01-01 00:00:00

  • Letter to the Editors: Concerning "Long-term safety and efficacy of AAV gene therapy in the canine model of glycogen storage disease type Ia" by Lee et al.

    abstract:: ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 评论,信件

    doi:10.1007/s10545-018-0248-2

    authors: Brooks ED,Kishnani PS,Koeberl DD

    更新日期:2018-11-01 00:00:00

  • View from inside.

    abstract:: ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 社论

    doi:10.1007/s10545-018-0214-z

    authors: Halai J

    更新日期:2018-11-01 00:00:00

  • Molecular biology and gene therapy for glycogen storage disease type Ib.

    abstract::Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the ubiquitously expressed glucose-6-phosphate (G6P) transporter (G6PT or SLC37A4). The primary function of G6PT is to translocate G6P from the cytoplasm into the lumen of the endoplasmic reticulum (ER). Inside the ER, G6P is hydrolyzed to glucose ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-018-0180-5

    authors: Chou JY,Cho JH,Kim GY,Mansfield BC

    更新日期:2018-11-01 00:00:00

  • Next-generation glycogen storage diseases.

    abstract:: ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 社论

    doi:10.1007/s10545-018-00250-0

    authors: Derks TGJ,Oosterveer MH,De Souza CF

    更新日期:2018-11-01 00:00:00

  • Synaptic metabolism and brain circuitries in inborn errors of metabolism.

    abstract:: ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 社论

    doi:10.1007/s10545-018-00252-y

    authors: García-Cazorla À,Artuch R,Bayès À

    更新日期:2018-11-01 00:00:00

  • Synaptic metabolism: a new approach to inborn errors of neurotransmission.

    abstract::To date, inborn errors of neurotransmitters have been defined based on the classic concept of inborn error of metabolism (IEM), and they include defects in synthesis, catabolism, and transport pathways. However, the omics era is bringing insights into new diseases and is leading to an extended definition of IEM includ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-018-0235-7

    authors: Tristán-Noguero A,García-Cazorla À

    更新日期:2018-11-01 00:00:00

  • Transcranial electrical stimulation (tES) mechanisms and its effects on cortical excitability and connectivity.

    abstract::In this review, we describe transcranial electrical stimulation (tES) techniques currently being used in neuroscientific research, including transcranial direct current (tDCS), alternating current (tACS) and random noise (tRNS) stimulation techniques. We explain how these techniques are used and summarise the proposed...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-018-0181-4

    authors: Reed T,Cohen Kadosh R

    更新日期:2018-07-13 00:00:00

  • Autism spectrum disorder: an early and frequent feature in cerebrotendinous xanthomatosis.

    abstract:BACKGROUND:Cerebrotendinous xanthomatosis (CTX) is an autosomal recessively inherited inborn error of metabolism (IEM) due to mutations in the CYP27A1 gene. The clinical picture ranges from being nearly asymptomatic in early childhood, up to severe disability at adult age. Infantile-onset diarrhea and juvenile-onset ca...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-017-0086-7

    authors: Stelten BML,Bonnot O,Huidekoper HH,van Spronsen FJ,van Hasselt PM,Kluijtmans LAJ,Wevers RA,Verrips A

    更新日期:2018-07-01 00:00:00

  • Biochemical markers and neuropsychological functioning in distal urea cycle disorders.

    abstract::Urea cycle disorders often present as devastating metabolic conditions, resulting in high mortality and significant neuropsychological damage, despite treatment. The Urea Cycle Disorders Longitudinal Study is a natural history study that collects data from regular clinical follow-up and neuropsychological testing. Thi...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-017-0132-5

    authors: Waisbren SE,Cuthbertson D,Burgard P,Holbert A,McCarter R,Cederbaum S,Members of the Urea Cycle Disorders Consortium.

    更新日期:2018-07-01 00:00:00

  • Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies.

    abstract::We present an update to the status of research on succinic semialdehyde dehydrogenase (SSADH) deficiency (SSADHD), a rare disorder of GABA metabolism. This is an unusual disorder featuring the accumulation of both GABA and its neuromodulatory analog, gamma-hydroxybutyric acid (GHB), and recent studies have advanced th...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-018-0153-8

    authors: Vogel KR,Ainslie GR,Walters DC,McConnell A,Dhamne SC,Rotenberg A,Roullet JB,Gibson KM

    更新日期:2018-07-01 00:00:00

  • Contribution of tandem mass spectrometry to the diagnosis of lysosomal storage disorders.

    abstract::Tandem mass spectrometry (MS/MS) is a highly sensitive and specific technique. Thanks to the development of triple quadrupole analyzers, it is becoming more widely used in laboratories working in the field of inborn errors of metabolism. We review here the state of the art of this technique applied to the diagnosis of...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-017-0126-3

    authors: Piraud M,Pettazzoni M,Lavoie P,Ruet S,Pagan C,Cheillan D,Latour P,Vianey-Saban C,Auray-Blais C,Froissart R

    更新日期:2018-05-01 00:00:00

  • Flux analysis of inborn errors of metabolism.

    abstract::Patients with an inborn error of metabolism (IEM) are deficient of an enzyme involved in metabolism, and as a consequence metabolism reprograms itself to reach a new steady state. This new steady state underlies the clinical phenotype associated with the deficiency. Hence, we need to know the flux of metabolites throu...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章,评审

    doi:10.1007/s10545-017-0124-5

    authors: Reijngoud DJ

    更新日期:2018-05-01 00:00:00

  • Next-generation metabolic screening: targeted and untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients.

    abstract::The implementation of whole-exome sequencing in clinical diagnostics has generated a need for functional evaluation of genetic variants. In the field of inborn errors of metabolism (IEM), a diverse spectrum of targeted biochemical assays is employed to analyze a limited amount of metabolites. We now present a single-p...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-017-0131-6

    authors: Coene KLM,Kluijtmans LAJ,van der Heeft E,Engelke UFH,de Boer S,Hoegen B,Kwast HJT,van de Vorst M,Huigen MCDG,Keularts IMLW,Schreuder MF,van Karnebeek CDM,Wortmann SB,de Vries MC,Janssen MCH,Gilissen C,Engel J,Wevers RA

    更新日期:2018-05-01 00:00:00

  • Globotriaosylsphingosine (Lyso-Gb3) as a biomarker for cardiac variant (N215S) Fabry disease.

    abstract::Fabry disease (FD) is a multi-systemic X-linked lysosomal disorder caused by the deficient activity of α-galactosidase-A enzyme, which leads to accumulation of glycosphingolipids in various body tissues. The N215S mutation is a known variant of FD, with a late onset cardiac phenotype. Consensus guidelines acknowledged...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-017-0127-2

    authors: Alharbi FJ,Baig S,Auray-Blais C,Boutin M,Ward DG,Wheeldon N,Steed R,Dawson C,Hughes D,Geberhiwot T

    更新日期:2018-03-01 00:00:00

  • Correlation between the molecular effects of mutations at the dimer interface of alanine-glyoxylate aminotransferase leading to primary hyperoxaluria type I and the cellular response to vitamin B6.

    abstract::Primary hyperoxaluria type I (PH1) is a rare disease caused by the deficit of liver alanine-glyoxylate aminotransferase (AGT). AGT prevents oxalate formation by converting peroxisomal glyoxylate to glycine. When the enzyme is deficient, progressive calcium oxalate stones deposit first in the urinary tract and then at ...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-017-0105-8

    authors: Dindo M,Oppici E,Dell'Orco D,Montone R,Cellini B

    更新日期:2018-03-01 00:00:00

  • Biochemical changes and clinical outcomes in 34 patients with classic galactosemia.

    abstract::Impaired activity of galactose-1-phosphate uridyltransferase (GALT) causes galactosemia, an autosomal recessive disorder of galactose metabolism. Early initiation of a galactose-restricted diet can prevent or resolve neonatal complications. Despite therapy, patients often experience long-term complications including s...

    journal_title:Journal of inherited metabolic disease

    pub_type: 杂志文章

    doi:10.1007/s10545-018-0136-9

    authors: Yuzyuk T,Viau K,Andrews A,Pasquali M,Longo N

    更新日期:2018-03-01 00:00:00

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