abstract：:To program a goal-directed response in the presence of acoustic reflections, the audio-motor system should suppress the detection of time-delayed sources. We examined the effects of spatial separation and inter-stimulus delay on the ability of human listeners to localize a pair of broadband sounds in the horizontal pl...

journal_title：Journal of neurophysiology

authors： van Bentum GC,van Wanrooij MM,Van Opstal AJ

更新日期：2020-12-30 00:00:00

abstract：:In this tribute to Reggie Edgerton, I briefly review the spinal mechanisms that coordinate locomotion and the interaction between the different sensory mechanisms that help coordinate the locomotor movements and the central locomotor network. The step cycle has four distinct parts, the support phase, the lift off, the...

journal_title：Journal of neurophysiology

authors： Grillner S

更新日期：2020-12-23 00:00:00

abstract：:Cacna1a encodes the pore-forming α1A subunit of CaV2.1 voltage-dependent calcium channels, which regulate neuronal excitability and synaptic transmission. Purkinje cells in the cortex of cerebellum abundantly express these CaV2.1 channels. Here, we show that homozygous tottering (tg) mice, which carry a loss-of-functi...

journal_title：Journal of neurophysiology

authors： de Oude NL,Hoebeek FE,Ten Brinke MM,de Zeeuw CI,Boele HJ

更新日期：2020-12-16 00:00:00

abstract：:Previous studies have reported an important relationship between increasing age, vestibular impairment, and increased risk of falls. Recently, noisy galvanic vestibular stimulation (nGVS) has been shown to improve postural control in older adults during and potentially following stimulation. However, this effect of nG...

journal_title：Journal of neurophysiology

authors： Nooristani M,Bigras C,Lafontaine L,Bacon BA,Maheu M,Champoux F

更新日期：2020-12-09 00:00:00

abstract：:Changes to cerebral miRNA expression have been implicated in the progression of Alzheimer's disease (AD), as miRNAs that regulate the expression of gene products involved in amyloid beta (Aβ) processing, such as BACE1, are dysregulated in those that suffer from AD. Exercise training improves cognition and reduces BACE...

journal_title：Journal of neurophysiology

authors： Dungan CM,Valentino T,Vechetti IJ Jr,Zdunek CJ,Murphy MP,Lin AL,McCarthy JJ,Peterson CA

更新日期：2020-12-01 00:00:00

abstract：:The cortical N1 response to balance perturbation is observed in electroencephalography recordings simultaneous to automatic balance-correcting muscle activity. We recently observed larger cortical N1s in individuals who had greater difficulty resisting compensatory steps, suggesting the N1 may be influenced by steppin...

journal_title：Journal of neurophysiology

authors： Payne AM,Ting LH

更新日期：2020-12-01 00:00:00

abstract：:Sopite syndrome, centered around the drowsiness, lethargy, and irritability associated with motion sickness, can be induced by exposure to low-frequency motion. It is known that the vestibular apparatus plays an important role in the pathogenesis of motion sickness, which features several autonomic responses, and we h...

journal_title：Journal of neurophysiology

authors： Foster M,Singh N,Kwok K,Macefield VG

更新日期：2020-12-01 00:00:00

abstract：:Neural implants with large numbers of electrodes have become an important tool for examining brain functions. However, these devices typically displace a large intracranial volume compared with the neurons they record. This large size limits the density of implants, provokes tissue reactions that degrade chronic perfo...

journal_title：Journal of neurophysiology

authors： Egert D,Pettibone JR,Lemke S,Patel PR,Caldwell CM,Cai D,Ganguly K,Chestek CA,Berke JD

更新日期：2020-12-01 00:00:00

abstract：:Persistent inward currents are important to motoneuron excitability and firing behaviors and also have been implicated in excitotoxicity. In particular, L-type Ca2+ channels, usually located on motoneuron dendrites, play a primary role in amplification of synaptic inputs. However, recent experimental findings on L-typ...

journal_title：Journal of neurophysiology

authors： Mousa MH,Elbasiouny SM

更新日期：2020-10-01 00:00:00

abstract：:Previously, an essential tremor-like phenotype has been noted in animals with a global knockout of the GABAAα1 subunit. Given the hypothesized role of the cerebellum in tremor, including essential tremor, we used transgenic mice to selectively knock out the GABAAα1 subunit from cerebellar Purkinje cells. We examined t...

journal_title：Journal of neurophysiology

authors： Nietz A,Krook-Magnuson C,Gutierrez H,Klein J,Sauve C,Hoff I,Christenson Wick Z,Krook-Magnuson E

更新日期：2020-10-01 00:00:00

abstract：:Sensorineural hearing loss (SNHL) causes an overall deficit in binaural hearing, including the abilities to localize sound sources, discriminate interaural time and level differences (ITDs and ILDs, respectively), and utilize binaural cues to aid signal detection and comprehension in noisy environments. Few studies ha...

journal_title：Journal of neurophysiology

authors： Haragopal H,Dorkoski R,Pollard AR,Whaley GA,Wohl TR,Stroud NC,Day ML

更新日期：2020-10-01 00:00:00

abstract：:Motor behavior often occurs in environments with multiple goal options that can vary during the ongoing action. We explored this situation by requiring subjects to select between different target options during an ongoing reach. During split trials the original target was replaced with a left and a right flanking targ...

journal_title：Journal of neurophysiology

authors： Kurtzer IL,Muraoka T,Singh T,Prasad M,Chauhan R,Adhami E

更新日期：2020-10-01 00:00:00

abstract：:A single bout of aerobic exercise improves executive function; however, the mechanism for the improvement remains unclear. One proposal asserts that an exercise-mediated increase in cerebral blood flow (CBF) enhances the efficiency of executive-related cortical structures. To examine this, participants completed separ...

journal_title：Journal of neurophysiology

authors： Tari B,Vanhie JJ,Belfry GR,Shoemaker JK,Heath M

更新日期：2020-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the most common neurological disorders causing memory reduction, particularly short-term memory (STM). We showed that, during TBI-induced inflammation, increased blood content of fibrinogen (Fg) enhanced vascular protein transcytosis and deposition of extravasated Fg in vasculo-a...

journal_title：Journal of neurophysiology

authors： Charkviani M,Muradashvili N,Sulimai N,Lominadze D

更新日期：2020-08-01 00:00:00

abstract：:A growing body of evidence suggests that decision-making and action execution are governed by partly overlapping operating principles. Especially, previous work proposed that a shared decision urgency/movement vigor signal, possibly computed in the basal ganglia, coordinates both deliberation and movement durations in...

journal_title：Journal of neurophysiology

authors： Reynaud AJ,Saleri Lunazzi C,Thura D

更新日期：2020-08-01 00:00:00

abstract：:Beta-band oscillations are a dominant feature in the sensorimotor system, which includes movement-related beta desynchronization (MRBD) during the preparation and execution phases of movement and postmovement beta synchronization (PMBS) on movement cessation. Many studies have linked this rhythm to motor functions. Ho...

journal_title：Journal of neurophysiology

authors： Zhang X,Li H,Xie T,Liu Y,Chen J,Long J

更新日期：2020-08-01 00:00:00

abstract：:Neural oscillations are observed ubiquitously in the mammalian brain, but their stability is known to be rather variable. Some oscillations are tonic and last for seconds or even minutes. Other oscillations appear as unstable bursts. Likewise, some oscillations rely on excitatory AMPAergic synapses, but others are GAB...

journal_title：Journal of neurophysiology

authors： Peterson EJ,Voytek B

更新日期：2020-07-01 00:00:00

abstract：:The aim of the study was to examine whether the sustained increases in the excitability of afferent fibers traversing the dorsal columns evoked by their polarization depend on the branching points of these fibers. To this end, the effects of epidural polarization were compared in four spinal regions in deeply anesthet...

journal_title：Journal of neurophysiology

authors： Li Y,Hari K,Lucas-Osma AM,Fenrich KK,Bennett DJ,Hammar I,Jankowska E

更新日期：2020-07-01 00:00:00

abstract：:This study determined the effect of mixed (slip- and trip-like stance perturbation) training on reactive responses in people with chronic stroke (PwCS) and examined modulation of their reactive responses on higher intensity perturbations posttraining (scaling). Twelve PwCS were exposed to consecutive blocks of treadmi...

journal_title：Journal of neurophysiology

authors： Dusane S,Bhatt T

更新日期：2020-07-01 00:00:00

abstract：:The primate superior colliculus (SC) is causally involved in microsaccade generation. Moreover, visually responsive SC neurons across this structure's topographic map, even at peripheral eccentricities much larger than the tiny microsaccade amplitudes, exhibit significant modulations of evoked response sensitivity whe...

journal_title：Journal of neurophysiology

authors： Khademi F,Chen CY,Hafed ZM

更新日期：2020-06-01 00:00:00

abstract：:We perceive objects as permanent and stable despite frequent occlusions and eye movements, but their representation in the visual cortex is neither permanent nor stable. Feature selective cells respond only as long as objects are visible, and their responses depend on eye position. We explored the hypothesis that the ...

journal_title：Journal of neurophysiology

authors： Zhu SD,Zhang LA,von der Heydt R

更新日期：2020-05-01 00:00:00

abstract：:The parafacial respiratory group (pFRG), located in the lateral aspect of the rostroventral lateral medulla, has been described as a conditional expiratory oscillator that emerges mainly in conditions of high metabolic challenges to increase breathing. The convergence of inhibitory and excitatory inputs to pFRG and th...

journal_title：Journal of neurophysiology

authors： Silva JDN,Oliveira LM,Souza FC,Moreira TS,Takakura AC

更新日期：2020-05-01 00:00:00

abstract：:Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement seque...

journal_title：Journal of neurophysiology

authors： Ariani G,Kwon YH,Diedrichsen J

更新日期：2020-05-01 00:00:00

abstract：:In rats, forelimb movements are evoked from two cortical regions, the caudal and rostral forelimb areas (CFA and RFA, respectively). These areas are densely interconnected and RFA induces complex and powerful modulations of CFA outputs. CFA and RFA also have interhemispheric connections, and these areas from both hemi...

journal_title：Journal of neurophysiology

authors： Touvykine B,Elgbeili G,Quessy S,Dancause N

更新日期：2020-04-01 00:00:00

abstract：:In recent years, electroencephalography and magnetoencephalography (MEG) have both been used to investigate the response in human auditory cortex to musical sounds that are perceived as consonant or dissonant. These studies have typically focused on the transient components of the physiological activity at sound onset...

journal_title：Journal of neurophysiology

authors： Andermann M,Patterson RD,Rupp A

更新日期：2020-04-01 00:00:00

abstract：:Generalizing newly learned movement patterns beyond the training context is challenging for most motor learning situations. Here we tested whether learning of a new physical property of the arm during self-initiated reaching generalizes to new arm configurations. Human participants performed a single-joint elbow reach...

journal_title：Journal of neurophysiology

authors： Maeda RS,Zdybal JM,Gribble PL,Pruszynski JA

更新日期：2020-03-01 00:00:00

abstract：:Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment (adjustment of their frequency to match the input frequency) is thought to support many cognitive functions and indicate functional flexibility. Although previous studies have explored the influence of various circuit prop...

journal_title：Journal of neurophysiology

authors： Papasavvas CA,Trevelyan AJ,Kaiser M,Wang Y

更新日期：2020-03-01 00:00:00

abstract：:N-methyl-d-aspartate receptors (NMDARs) are fundamental coincidence detectors of synaptic activity necessary for the induction of synaptic plasticity and synapse stability. Adjusting NMDAR synaptic content, whether by receptor insertion or lateral diffusion between extrasynaptic and synaptic compartments, could play a...

journal_title：Journal of neurophysiology

authors： McQuate A,Barria A

更新日期：2020-03-01 00:00:00

abstract：:Directional hearing is crucial for animals depending on acoustic signals to locate a mate. We focused on crickets to explore the reliability of directional information forwarded to the brain by the ascending auditory interneuron AN1, which is crucial for phonotactic behavior. We presented calling song from -45° to +45...

journal_title：Journal of neurophysiology

authors： Lv M,Zhang X,Hedwig B

更新日期：2020-03-01 00:00:00

abstract：:Unitary pallido-nigral synaptic currents were measured using optogenetic stimulation, which activated up to three unitary synaptic inputs to each substantia nigra pars reticulata (SNr) cell. Episodic barrages of synaptic conductances were generated based on in vivo firing patterns of globus pallidus pars externa (GPe)...

journal_title：Journal of neurophysiology

authors： Simmons DV,Higgs MH,Lebby S,Wilson CJ

更新日期：2020-02-01 00:00:00

abstract：:Gain-of-function variants in voltage-gated sodium channel NaV1.7 that increase firing frequency and spontaneous firing of dorsal root ganglion (DRG) neurons have recently been identified in 5-10% of patients with idiopathic small fiber neuropathy (I-SFN). Our previous in vitro observations suggest that enhanced sodium...

journal_title：Journal of neurophysiology

authors： Lee SI,Hoeijmakers JGJ,Faber CG,Merkies ISJ,Lauria G,Waxman SG

更新日期：2020-02-01 00:00:00

abstract：:The Wilson-Cowan population model of neural activity has greatly influenced our understanding of the mechanisms for the generation of brain rhythms and the emergence of structured brain activity. As well as the many insights that have been obtained from its mathematical analysis, it is now widely used in the computati...

journal_title：Journal of neurophysiology

authors： Byrne Á,O'Dea RD,Forrester M,Ross J,Coombes S

更新日期：2020-02-01 00:00:00

abstract：:Head rotation, translation, and tilt with respect to a gravitational field elicit reflexive eye movements that partially stabilize images of Earth-fixed objects on the retinas of humans and other vertebrates. Compared with the angular vestibulo-ocular reflex, responses to translation and tilt, collectively called the ...

journal_title：Journal of neurophysiology

authors： Hageman KN,Chow MR,Roberts D,Della Santina CC

更新日期：2020-01-01 00:00:00

abstract：:The Wilson-Cowan equations were originally shown to produce limit cycle oscillations for a range of parameters. Others subsequently showed that two coupled Wilson-Cowan oscillators could produce chaos, especially if the oscillator coupling was from inhibitory interneurons of one oscillator to excitatory neurons of the...

journal_title：Journal of neurophysiology

authors： Wilson HR

更新日期：2019-12-01 00:00:00

abstract：:The grip force applied to maintain grasp of a handheld object has been typically reported as tightly coupled to the load force exerted by the object as it is actively manipulated, occurring proportionally and consistently in phase with changes in load force. However, continuous grip force-load force coupling breaks do...

journal_title：Journal of neurophysiology

authors： Grover FM,Schwab SM,Silva PL,Lorenz T,Riley MA

更新日期：2019-12-01 00:00:00

abstract：:Cholinergic signaling coupled to sensory-driven neuronal depolarization is essential for modulating lasting changes in deep-layer neural excitability and experience-dependent plasticity in the primary auditory cortex. However, the underlying cellular mechanism(s) associated with coincident cholinergic receptor activat...

journal_title：Journal of neurophysiology

authors： Fu X,Ye H,Jia H,Wang X,Chomiak T,Luo F

更新日期：2019-12-01 00:00:00

abstract：:Microsleeps are brief episodes of arousal level decrease manifested through behavioral signs. Brain activity during microsleep in the presence of external stimulus remains poorly understood. In this study, we sought to understand neural responses to auditory stimulation during microsleep. We gave participants the simp...

journal_title：Journal of neurophysiology

authors： Yong Z,Tan JH,Hsieh PJ

更新日期：2019-12-01 00:00:00

abstract：:In the absence of any obvious input, sensory neurons and interneurons can display resting or spontaneous activity. This is often regarded as noise and removed through trial averaging, although it may reflect history-dependent modulation of tuning or fidelity and, thus, be of functional relevance to downstream interneu...

journal_title：Journal of neurophysiology

authors： Lepreux G,Haupt SS,Dürr V

更新日期：2019-12-01 00:00:00

abstract：:We investigated whether the proprioceptive eye position signal after the execution of a saccadic eye movement is used to estimate the accuracy of the movement. If so, saccadic adaptation, the mechanism that maintains saccade accuracy, could use this signal in a similar way as it uses visual feedback after the saccade....

journal_title：Journal of neurophysiology

authors： Gremmler S,Lappe M

更新日期：2019-11-01 00:00:00

abstract：:For human locomotion, varying environments require adjustments of the motor system. We asked whether age affects gait balance recovery adaptation, its retention over months, and the transfer of adaptation to an untrained reactive balance task. Healthy adults (26 young, 27 middle-aged, and 25 older; average ages 24, 52...

journal_title：Journal of neurophysiology

authors： König M,Epro G,Seeley J,Potthast W,Karamanidis K

更新日期：2019-11-01 00:00:00