abstract：:Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy preferentially depletes intrahepatic regula...

journal_title：Journal of autoimmunity

authors： Buitrago-Molina LE,Pietrek J,Noyan F,Schlue J,Manns MP,Wedemeyer H,Hardtke-Wolenski M,Jaeckel E

更新日期：2021-02-01 00:00:00

abstract：:The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) expression profiles were analysed in tissues with differing disease st...

journal_title：Journal of autoimmunity

authors： Clanchy FIL,Borghese F,Bystrom J,Balog A,Penn H,Hull DN,Wells GMA,Kiriakidis S,Taylor PC,Sacre SM,Williams LM,Stone TW,Mageed RA,Williams RO

更新日期：2021-01-22 00:00:00

abstract：:Epitope spreading is an important mechanism for the development of autoantibodies (autoAbs) in autoimmune diseases. The study of epitope spreading in human autoimmune diseases is limited due to the major challenge of identifying the initial/primary target epitopes on autoantigens in autoimmune diseases. We have been s...

journal_title：Journal of autoimmunity

authors： Peng B,Temple BR,Yang J,Geng S,Culton DA,Qian Y

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by recurrent thrombosis and/or pregnancy morbidity, in the presence of antibodies to β2 glycoprotein-I (β2GPI), prothrombin or Lupus anticoagulant (LA). Anti-β2GPI antibodies recognize complexes of β2GPI dimers with CXCL4 chemokine and...

journal_title：Journal of autoimmunity

authors： Patsouras M,Tsiki E,Karagianni P,Vlachoyiannopoulos PG

更新日期：2020-12-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) can progress to cytokine storm that is associated with organ dysfunction and death. The purpose of the present study is to determine clinical characteristics associated with 28 day in-hospital survival in patients with coronavirus disease 2019 (COVID-19) that received tocilizumab. T...

journal_title：Journal of autoimmunity

authors： Morrison AR,Johnson JM,Griebe KM,Jones MC,Stine JJ,Hencken LN,To L,Bianchini ML,Vahia AT,Swiderek J,Ramesh MS,Peters MA,Smith ZR

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. METHODS:Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compare...

journal_title：Journal of autoimmunity

authors： Leclercq M,Langlois V,Girszyn N,Le Besnerais M,Benhamou Y,Levesque H,Muraine M,Gueudry J

更新日期：2020-09-01 00:00:00

abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

journal_title：Journal of autoimmunity

authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

更新日期：2020-08-01 00:00:00

abstract：:The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an infectious disease caused by SARS-CoV-2, which causes pneumonia, requires intensive care unit hospitalization in about 10% of cases and can lead to ...

journal_title：Journal of autoimmunity

authors： Perricone C,Triggianese P,Bartoloni E,Cafaro G,Bonifacio AF,Bursi R,Perricone R,Gerli R

更新日期：2020-07-01 00:00:00

abstract：:The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those with an underlying chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years, following ...

journal_title：Journal of autoimmunity

authors： Yang Y,Peng F,Wang R,Yange M,Guan K,Jiang T,Xu G,Sun J,Chang C

更新日期：2020-05-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by necrotizing vasculitis with the presence of pathogenic ANCA. ANCA can potentially cause neutrophil activation and induce neutrophil extracellular traps (NETs), resulting in endothelial damage as well as activation of autoreacti...

journal_title：Journal of autoimmunity

authors： Watanabe-Kusunoki K,Nakazawa D,Kusunoki Y,Kudo T,Hattanda F,Nishio S,Masuda S,Tomaru U,Kondo T,Atsumi T,Ishizu A

更新日期：2020-03-01 00:00:00

abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

journal_title：Journal of autoimmunity

authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

更新日期：2020-03-01 00:00:00

abstract：:Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...

journal_title：Journal of autoimmunity

authors： Voynova E,Lefebvre F,Qadri A,Muller S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Gut dysbiosis has been reported implicated in ankylosing spondylitis (AS), a common chronic inflammatory disease mainly affects sacroiliac joints and spine. Utilizing deep sequencing on the feces of untreated AS patients, our study aimed at providing an in-depth understanding of AS gut microbiota. METHODS:We...

journal_title：Journal of autoimmunity

authors： Zhou C,Zhao H,Xiao XY,Chen BD,Guo RJ,Wang Q,Chen H,Zhao LD,Zhang CC,Jiao YH,Ju YM,Yang HX,Fei YY,Wang L,Shen M,Li H,Wang XH,Lu X,Yang B,Liu JJ,Li J,Peng LY,Zheng WJ,Zhang CY,Zhou JX,Wu QJ,Yang YJ,Su

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The aberrant recognition of self-nucleic acids by the innate immune system contributes to the pathology of several autoimmune diseases. Although microbial DNA and, in certain instances, self-DNA that is released from damaged cells are primarily recognized by Toll-like receptor 9 (TLR9), recent evidence sugge...

journal_title：Journal of autoimmunity

authors： Zentsova I,Parackova Z,Kayserova J,Palova-Jelinkova L,Vrabcova P,Volfova N,Sumnik Z,Pruhova S,Petruzelkova L,Sediva A

更新日期：2019-12-01 00:00:00

abstract：:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by an autoimmune reaction against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune complexes accumulate in t...

journal_title：Journal of autoimmunity

authors： Taylor S,Pieri K,Nanni P,Tica J,Barratt J,Didangelos A

更新日期：2019-12-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto thyroiditis (HT), are the most prevalent organ-specific autoimmune diseases, but their pathogenesis is still incompletely understood. The PD-1/PD-L1 pathway is an important mechanism of peripheral tolerance that has not been investigated in ...

journal_title：Journal of autoimmunity

authors： Álvarez-Sierra D,Marín-Sánchez A,Ruiz-Blázquez P,de Jesús Gil C,Iglesias-Felip C,González Ó,Casteras A,Costa RF,Nuciforo P,Colobran R,Pujol-Borrell R

更新日期：2019-09-01 00:00:00

abstract：:Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to explain increased UVB-induced inflammation remain unclear. This paper compares the role...

journal_title：Journal of autoimmunity

authors： Wolf SJ,Estadt SN,Theros J,Moore T,Ellis J,Liu J,Reed TJ,Jacob CO,Gudjonsson JE,Kahlenberg JM

更新日期：2019-09-01 00:00:00

abstract：:The interaction over time of genetic, epigenetic and environmental factors (i.e., autoimmune ecology) increases or decreases the liability an individual would have to develop an autoimmune disease (AD) depending on the misbalance between risk and protective effects. Pathogens have been the most common antecedent event...

journal_title：Journal of autoimmunity

authors： Pacheco Y,Acosta-Ampudia Y,Monsalve DM,Chang C,Gershwin ME,Anaya JM

更新日期：2019-09-01 00:00:00

abstract：:Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our wo...

journal_title：Journal of autoimmunity

authors： Dieudonné Y,Gies V,Guffroy A,Keime C,Bird AK,Liesveld J,Barnas JL,Poindron V,Douiri N,Soulas-Sprauel P,Martin T,Meffre E,Anolik JH,Korganow AS

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

journal_title：Journal of autoimmunity

authors： Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

更新日期：2019-07-01 00:00:00

abstract：:Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

journal_title：Journal of autoimmunity

authors： Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

更新日期：2019-07-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

journal_title：Journal of autoimmunity

authors： Rimassa L,Personeni N,Aghemo A,Lleo A

更新日期：2019-06-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：:The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved methods of detection and advanced laboratory methodology. Patients with PIDs have an increased...

journal_title：Journal of autoimmunity

authors： Amaya-Uribe L,Rojas M,Azizi G,Anaya JM,Gershwin ME

更新日期：2019-05-01 00:00:00

abstract：:The development of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. We examine whether autoimmunity contributes independently to allograft rejection. In a MHC class II-mismatched murine model of chronic humoral rejection, we report that effector antinuclea...

journal_title：Journal of autoimmunity

authors： Qureshi MS,Alsughayyir J,Chhabra M,Ali JM,Goddard MJ,Devine CA,Conlon TM,Linterman MA,Motallebzadeh R,Pettigrew GJ

更新日期：2019-03-01 00:00:00

abstract：:Women with antiphospholipid antibodies (aPL) are at high risk for pregnancy complications, such as preeclampsia. We previously demonstrated that aPL recognizing β2GPI promote an extravillous trophoblast pro-inflammatory, anti-migratory and anti-angiogenic profile similar to that seen in preeclampsia. Since preeclampsi...

journal_title：Journal of autoimmunity

authors： Mulla MJ,Pasternak MC,Salmon JE,Chamley LW,Abrahams VM

更新日期：2019-03-01 00:00:00

abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

journal_title：Journal of autoimmunity

authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

更新日期：2019-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

journal_title：Journal of autoimmunity

authors： Fava A,Petri M

更新日期：2019-01-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

journal_title：Journal of autoimmunity

authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

更新日期：2018-12-01 00:00:00

abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

journal_title：Journal of autoimmunity

authors： Bonam SR,Wang F,Muller S

更新日期：2018-11-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) cause vascular thrombosis (VT) and/or pregnancy morbidity (PM). Differential mechanisms however, underlying the pathogenesis of these different manifestations of antiphospholipid syndrome (APS) are not fully understood. Therefore, we compared the effects of aPL from patients with thro...

journal_title：Journal of autoimmunity

authors： Ripoll VM,Pregnolato F,Mazza S,Bodio C,Grossi C,McDonnell T,Pericleous C,Meroni PL,Isenberg DA,Rahman A,Giles IP

更新日期：2018-09-01 00:00:00

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nerves evolving with diffuse sensory and motor symptoms. Although it is claimed that in neurodegenerative pathologies, a common feature is the failure of proteolytic systems to adequately eliminate aggregated or...

journal_title：Journal of autoimmunity

authors： Brun S,Schall N,Bonam SR,Bigaut K,Mensah-Nyagan AG,de Sèze J,Muller S

更新日期：2018-08-01 00:00:00

abstract：:Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, ...

journal_title：Journal of autoimmunity

authors： Chighizola CB,Pregnolato F,Andreoli L,Bodio C,Cesana L,Comerio C,Gerosa M,Grossi C,Kumar R,Lazzaroni MG,Mahler M,Mattia E,Nalli C,Norman GL,Raimondo MG,Ruffatti A,Tonello M,Trespidi L,Tincani A,Borghi MO,Meroni PL

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...

journal_title：Journal of autoimmunity

authors： Zhang L,Li Y,Qiu W,Bell BA,Dvorina N,Baldwin WM 3rd,Singer N,Kern T,Caspi RR,Fox DA,Lin F

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To identify potential causative markers involved in the development of early-onset myasthenia gravis (EOMG) in the MHC and non-MHC regions that may interact with the HLA-B*08:01 allele. METHODS:We analyzed 583 MG patients and identified 5 patients homozygous for the disease-associated ancestral haplotype 8.1...

journal_title：Journal of autoimmunity

authors： Varade J,Wang N,Lim CK,Zhang T,Zhang Y,Liu X,Piehl F,Matell R,Cao H,Xu X,Hammarström L

更新日期：2018-03-01 00:00:00

abstract：:Autoinflammatory diseases (AUIDs) are a genetically heterogeneous group of rheumatic diseases characterized by episodic inflammation linked with dysregulated innate immune responses. In this review, we summarize the molecular mechanisms altered by disease-associated variants in several AUIDs, including NOD2-associated...

journal_title：Journal of autoimmunity

authors： Hua Y,Shen M,McDonald C,Yao Q

更新日期：2018-03-01 00:00:00

abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

journal_title：Journal of autoimmunity

authors： Harbige J,Eichmann M,Peakman M

更新日期：2017-11-01 00:00:00

abstract：:With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by immune activation, vascular complications, and excessive fibrosis in internal organs. Genetic studies, including candidate gene association studies, genome-wide association studies, and whole-exome sequencing have supported the notion ...

journal_title：Journal of autoimmunity

authors： Tsou PS,Sawalha AH

更新日期：2017-09-01 00:00:00

abstract：:The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

journal_title：Journal of autoimmunity

authors： Qin K,Han C,Zhang H,Li T,Li N,Cao X

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of biosimilars of anti-tumor necrosis factor (TNF)-α agents compared to their reference agents in immune mediated diseases. METHODS:Electronic databases were searched for randomized controlled trials (RCTs) assessing the efficacy and safety of biosimilars of anti-TNF-α age...

journal_title：Journal of autoimmunity

authors： Komaki Y,Yamada A,Komaki F,Kudaravalli P,Micic D,Ido A,Sakuraba A

更新日期：2017-05-01 00:00:00