Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection.

abstract：:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered,...

journal_title：Journal of autoimmunity

authors： Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

更新日期：2012-12-01 00:00:00

abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

journal_title：Journal of autoimmunity

authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:This paper describes some of the methodological problems related to the measurement of cyclosporin. The clinical value of the measurements following organ transplantation are discussed and those areas also applying to autoimmune indications are highlighted. It is concluded that the routine use of cyclosporin monitorin...

journal_title：Journal of autoimmunity

authors： Holt DW,Johnston A

更新日期：1992-04-01 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00

abstract：:Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expre...

journal_title：Journal of autoimmunity

authors： Rattay K,Meyer HV,Herrmann C,Brors B,Kyewski B

更新日期：2016-02-01 00:00:00

abstract：:We compared the classical immunofluorescence test (IFT) and counterimmunoelectrophoresis method (CIE) with the new immunoblotting technique (IBT) for the detection of antinuclear antibodies (ANA). Sera from 200 patients were tested in all three assays. Patients were classified as having either rheumatic disease includ...

journal_title：Journal of autoimmunity

authors： Westgeest AA,van den Brink HG,de Jong J,Swaak AJ,Smeenk RJ

更新日期：1988-04-01 00:00:00

abstract：:In a proliferation assay, peripheral blood lymphocytes (PBL) from a relatively small proportion of myasthenia gravis (MG) patients and from controls responded to Torpedo acetylcholine receptor (T-AChR), which shows approximately 75% homology with the human AChR. Over 50% of MG patients responded to recombinant human A...

journal_title：Journal of autoimmunity

authors： Newsom-Davis J,Harcourt G,Sommer N,Beeson D,Willcox N,Rothbard JB

更新日期：1989-06-01 00:00:00

abstract：:The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

journal_title：Journal of autoimmunity

authors： Bearzatto M,Lampasona V,Belloni C,Bonifacio E

更新日期：2003-12-01 00:00:00

abstract：:To study the potential roles of cytokines in development and resolution of granulomatous experimental autoimmune thyroiditis (EAT), the kinetics of in vivo expression of cytokine genes in thyroid infiltrates was analysed using reverse transcriptase-PCR (RT-PCR). Both Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) c...

journal_title：Journal of autoimmunity

authors： Tang H,Sharp GC,Chen K,Braley-Mullen H

更新日期：1998-12-01 00:00:00

abstract：:Following the mass vaccinations against pandemic influenza A/H1N1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic neurological disorder characterized by excessive daytime ...

journal_title：Journal of autoimmunity

authors： Saariaho AH,Vuorela A,Freitag TL,Pizza F,Plazzi G,Partinen M,Vaarala O,Meri S

更新日期：2015-09-01 00:00:00

abstract：:Autoantibodies to adrenal medulla that gave a diffuse immunofluorescent staining pattern were detected in 17 out of 107 (16%) patients with newly diagnosed Type I diabetes mellitus, in 13 out of 178 (7%) patients with long lasting disease but in none of 80 mixed control sera tested. The antibodies were of IgG class an...

journal_title：Journal of autoimmunity

authors： Scherbaum WA,Mogel H,Boehm BO,Hedderich U,Glück M,Schernthaner G,Bottazzo GF,Pfeiffer EF

更新日期：1988-06-01 00:00:00

abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

journal_title：Journal of autoimmunity

authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

更新日期：2020-03-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

journal_title：Journal of autoimmunity

authors： Sonoda Y

更新日期：2008-05-01 00:00:00

abstract：:It has long been suggested that retroviral infection may play a role in the pathogenesis of autoimmune rheumatic disease. Particles resembling retroviruses have been reported in tissue from patients with Sjögren's syndrome, lupus and rheumatoid arthritis, and molecular mimicry between retroviral antigens and host prot...

journal_title：Journal of autoimmunity

authors： Brand A,Griffiths DJ,Herve C,Mallon E,Venables PJ

更新日期：1999-08-01 00:00:00

abstract：:It has been recently suggested that primary Sjögren's syndrome (SS) patients present with a variety of personality structure disturbances and psychiatric symptoms. To evaluate this finding further, we assessed hostility structure and psychiatric symptoms in 33 Sjögren's syndrome patients and compared the results with ...

journal_title：Journal of autoimmunity

authors： Drosos AA,Angelopoulos NV,Liakos A,Moutsopoulos HM

更新日期：1989-08-01 00:00:00

abstract：:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...

journal_title：Journal of autoimmunity

authors： Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JM

更新日期：2012-05-01 00:00:00

abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

journal_title：Journal of autoimmunity

authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

更新日期：1995-10-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：:T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu...

journal_title：Journal of autoimmunity

authors： Chang JC,Linarelli LG,Laxer JA,Froning KJ,Caralli LL,Brostoff SW,Carlo DJ

更新日期：1995-04-01 00:00:00

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

journal_title：Journal of autoimmunity

authors： Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

更新日期：2004-06-01 00:00:00

abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

journal_title：Journal of autoimmunity

authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

更新日期：1999-09-01 00:00:00

abstract：:The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at...

journal_title：Journal of autoimmunity

authors： Cihak J,Hoffmann-Fezer G,Wasl M,Merkle H,Kaspers B,Vainio O,Plachý J,Hála K,Wick G,Stangassinger M,Lösch U

更新日期：1998-04-01 00:00:00

abstract：:Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

journal_title：Journal of autoimmunity

authors： Kamei H

更新日期：2004-05-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

journal_title：Journal of autoimmunity

authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

更新日期：2018-12-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is implicated as a mediator of islet beta-cell destruction in autoimmune, insulin-dependent diabetes mellitus (IDDM). Because interleukin 12 (IL-12) is a potent inducer of IFN-gamma production, we sought evidence implicating IL-12 in IDDM development. In the present study, we used a revers...

journal_title：Journal of autoimmunity

authors： Rabinovitch A,Suarez-Pinzon WL,Sorensen O

更新日期：1996-10-01 00:00:00

abstract：:Sera from autoimmune patients and normal volunteers were tested for antibodies to the A1 core protein of heteronuclear ribonucleoprotein (hnRNP) particles by ELISA and Western blot assays. The A1 protein used in these studies was produced by recombinant DNA technology. Thirty-seven per cent of patients with systemic l...

journal_title：Journal of autoimmunity

authors： Jensen L,Kuff EL,Wilson SH,Steinberg AD,Klinman DM

更新日期：1988-02-01 00:00:00

abstract：:Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) o...

journal_title：Journal of autoimmunity

authors： Wang X,Erf GF

更新日期：2004-02-01 00:00:00

abstract：:Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...

journal_title：Journal of autoimmunity

authors： Voynova E,Lefebvre F,Qadri A,Muller S

更新日期：2020-03-01 00:00:00