Intracellular localization of histidyl-tRNA synthetase/Jo-1 antigen in T24 cells and some other cells.

abstract：:Mesenchymal stem cells (MSCs) are considered to be a promising platform for cell and gene therapy for a variety of diseases. First, in the field of hematopoietic stem cell transplantation, there are two applications of MSCs: 1) the improvement of stem cell engrafting and the acceleration of hematopoietic reconstitutio...

journal_title：Journal of autoimmunity

authors： Ozawa K,Sato K,Oh I,Ozaki K,Uchibori R,Obara Y,Kikuchi Y,Ito T,Okada T,Urabe M,Mizukami H,Kume A

更新日期：2008-05-01 00:00:00

abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

journal_title：Journal of autoimmunity

authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

更新日期：1990-12-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00

abstract：:The Sm antigenic complex is, besides dsDNA, the most important and specific autoimmune target in systemic lupus erythematosus (SLE). The population of anti-Sm Ab elicited is very heterogeneous in terms of epitope specificity resulting in a strong assay dependent detectability. Based on the description of a new autoant...

journal_title：Journal of autoimmunity

authors： Jaekel HP,Klopsch T,Benkenstein B,Grobe N,Baldauf A,Schoessler W,Werle E

更新日期：2001-12-01 00:00:00

abstract：:The purpose of this study was to characterize regulatory T cells (T(reg)) in skin lesions and peripheral blood from patients with dermatomyositis (DM) and to determine the serum levels of regulatory cytokines in the disease. In skin biopsy specimens from patients with DM, immunohistochemistry was performed for CD4(+),...

journal_title：Journal of autoimmunity

authors： Antiga E,Kretz CC,Klembt R,Massi D,Ruland V,Stumpf C,Baroni G,Hartmann M,Hartschuh W,Volpi W,Del Bianco E,Enk A,Fabbri P,Krammer PH,Caproni M,Kuhn A

更新日期：2010-12-01 00:00:00

abstract：:We have investigated the pathophysiological basis of cardiac dysfunction in autoimmune myocarditis and in the resulting dilated cardiomyopathy. To this end we utilized the myosin-induced autoimmune myocarditis model in BALB/c mice. Myocarditis has been found to be associated with massive ventricular lymphocyte infiltr...

journal_title：Journal of autoimmunity

authors： Less H,Shilkrut M,Rubinstein I,Berke G,Binah O

更新日期：1999-05-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

journal_title：Journal of autoimmunity

authors： Bearzatto M,Lampasona V,Belloni C,Bonifacio E

更新日期：2003-12-01 00:00:00

abstract：:The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved methods of detection and advanced laboratory methodology. Patients with PIDs have an increased...

journal_title：Journal of autoimmunity

authors： Amaya-Uribe L,Rojas M,Azizi G,Anaya JM,Gershwin ME

更新日期：2019-05-01 00:00:00

abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

journal_title：Journal of autoimmunity

authors： Chang C

更新日期：2014-02-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto thyroiditis (HT), are the most prevalent organ-specific autoimmune diseases, but their pathogenesis is still incompletely understood. The PD-1/PD-L1 pathway is an important mechanism of peripheral tolerance that has not been investigated in ...

journal_title：Journal of autoimmunity

authors： Álvarez-Sierra D,Marín-Sánchez A,Ruiz-Blázquez P,de Jesús Gil C,Iglesias-Felip C,González Ó,Casteras A,Costa RF,Nuciforo P,Colobran R,Pujol-Borrell R

更新日期：2019-09-01 00:00:00

abstract：:Psoriasis and Psoriatic Arthritis (PsA) are chronic inflammatory diseases that have a major impact on health. The prevalence and incidence estimates of these two closely related diseases show ethnic and geographic variations, being generally more common in the colder north than in the tropics. In Europe the prevalence...

journal_title：Journal of autoimmunity

authors： Chandran V,Raychaudhuri SP

更新日期：2010-05-01 00:00:00

abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...

journal_title：Journal of autoimmunity

authors： Ramiya VK,Shang XZ,Pharis PG,Wasserfall CH,Stabler TV,Muir AB,Schatz DA,Maclaren NK

更新日期：1996-06-01 00:00:00

abstract：:There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

journal_title：Journal of autoimmunity

authors： Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

更新日期：1992-04-01 00:00:00

abstract：:Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the pathogenesis of lupu...

journal_title：Journal of autoimmunity

authors： Koelsch KA,Webb R,Jeffries M,Dozmorov MG,Frank MB,Guthridge JM,James JA,Wren JD,Sawalha AH

更新日期：2013-03-01 00:00:00

abstract：:(Beta2-glycoprotein I (beta2GPI) is a plasma protein that plays an important role in the antigenic specificity of antiphospholipid autoantibodies (aPL). These antibodies are associated with an increased risk for thrombosis and recurrent foetal loss in humans. Crystallographic analysis of beta2GPI showed that its five ...

journal_title：Journal of autoimmunity

authors： Iverson GM,Matsuura E,Victoria EJ,Cockerill KA,Linnik MD

更新日期：2002-06-01 00:00:00

abstract：:The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunolog...

journal_title：Journal of autoimmunity

authors： Heresbach D,Alizadeh M,Reumaux D,Colombel JF,Delamaire M,Danze PM,Gosselin M,Genetet B,Bretagne JF,Semana G

更新日期：1996-12-01 00:00:00

abstract：:TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha early in life experience an acceleration in disease onset while TNF-alpha administered to adult NOD mice are ...

journal_title：Journal of autoimmunity

authors： Middlebrook AJ,Lebsack T,DeLuca D

更新日期：2007-09-01 00:00:00

abstract：:Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas periphera...

journal_title：Journal of autoimmunity

authors： Ramos-Ruiz R,Bernabeu C,Ariza A,Fernández JM,Larraga V,López-Bote JP

更新日期：1992-02-01 00:00:00

abstract：:Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking eff...

journal_title：Journal of autoimmunity

authors： Paschke R,Teuber J,Enger I,Schmeidl R,Schwedes U,Usadel KH

更新日期：1990-08-01 00:00:00

abstract：:Immune cell infiltration to the brain's territory was considered for decades to reflect a pathological process in which immune cells attack the central nervous system (CNS); such a process is observed in the inflammatory autoimmune disease, multiple sclerosis (MS). As neuroinflammatory processes within the CNS parench...

journal_title：Journal of autoimmunity

authors： Schwartz M,Baruch K

更新日期：2014-11-01 00:00:00

abstract：:B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

journal_title：Journal of autoimmunity

authors： Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

更新日期：2017-02-01 00:00:00

abstract：:The murine model of human insulin dependent diabetes mellitus (IDDM), the non-obese diabetic (NOD) mouse, develops a T cell-dependent destruction of pancreatic islets. While the target antigens are unknown, there is clearly a lack of tolerance to them. Neonatal intrathymic (i.t.) antigen injection has been successfull...

journal_title：Journal of autoimmunity

authors： Charlton B,Taylor-Edwards C,Tisch R,Fathman CG

更新日期：1994-10-01 00:00:00

abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

journal_title：Journal of autoimmunity

authors： Ge X,James EA,Reijonen H,Kwok WW

更新日期：2011-03-01 00:00:00

abstract：:The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regarding the causality between vaccines, such as measles and anti-hepatitis B virus (HBV), and multiple sclerosis (MS). Brain antibodies as well as clinical symptoms have be...

journal_title：Journal of autoimmunity

authors： Shoenfeld Y,Aron-Maor A

更新日期：2000-02-01 00:00:00

abstract：:Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

journal_title：Journal of autoimmunity

authors： Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

更新日期：2015-02-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

journal_title：Journal of autoimmunity

authors： Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

更新日期：2017-01-01 00:00:00

abstract：:University of California at Davis line 200 (UCD-200) chickens develop a hereditary connective tissue disease characterized by severe lymphocytic infiltration, vascular occlusion and fibrosis of skin and internal organs. To identify cellular immunological abnormalities in the acute inflammatory disease stage of this an...

journal_title：Journal of autoimmunity

authors： Gruschwitz MS,Moormann S,Krömer G,Sgonc R,Dietrich H,Boeck G,Gershwin ME,Boyd R,Wick G

更新日期：1991-08-01 00:00:00