Arthritis transferred by cells derived from pre-inflammatory rat synovium.

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nerves evolving with diffuse sensory and motor symptoms. Although it is claimed that in neurodegenerative pathologies, a common feature is the failure of proteolytic systems to adequately eliminate aggregated or...

journal_title：Journal of autoimmunity

authors： Brun S,Schall N,Bonam SR,Bigaut K,Mensah-Nyagan AG,de Sèze J,Muller S

更新日期：2018-08-01 00:00:00

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:The higher concordant occurrence of autoimmune diseases in monozygotic twins compared to dizygotic or sibling pairs supports the role for genetic susceptibility. For most conditions, however, concordance rates are considerably below 100% and lead to the estimate of the weight of genetics coined "heritability". In the ...

journal_title：Journal of autoimmunity

authors： Selmi C,Lu Q,Humble MC

更新日期：2012-12-01 00:00:00

abstract：:The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

journal_title：Journal of autoimmunity

authors： Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

更新日期：1994-04-01 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00

abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

journal_title：Journal of autoimmunity

authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking eff...

journal_title：Journal of autoimmunity

authors： Paschke R,Teuber J,Enger I,Schmeidl R,Schwedes U,Usadel KH

更新日期：1990-08-01 00:00:00

abstract：:The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an infectious disease caused by SARS-CoV-2, which causes pneumonia, requires intensive care unit hospitalization in about 10% of cases and can lead to ...

journal_title：Journal of autoimmunity

authors： Perricone C,Triggianese P,Bartoloni E,Cafaro G,Bonifacio AF,Bursi R,Perricone R,Gerli R

更新日期：2020-07-01 00:00:00

abstract：:New Zealand (NZ) mouse strains comprise both autoimmune and non-autoimmune animals: NZ black (NZB) mice and the F1 hybrid (NZB/W) of NZB and NZ white (NZW) mice show spontaneous autoimmune disease by 6 months of age and die before the first year of age from renal disease, while NZW mice do not show autoimmune disorder...

journal_title：Journal of autoimmunity

authors： Esaguy N,Macedo PM,Castro AP,Aguas AP

更新日期：1992-10-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:Approximately 25% of mature T cells possess two distinct cytoplasmic T cell receptor (TCR) alpha-chains, due to productive gene rearrangements of both alleles. Expression of two different alpha-chains at the cell surface is a potential risk factor for development of autoimmunity. However, it has been difficult to dete...

journal_title：Journal of autoimmunity

authors： Corthay A,Nandakumar KS,Holmdahl R

更新日期：2001-06-01 00:00:00

abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

journal_title：Journal of autoimmunity

authors： Daikh DI,Wofsy D

更新日期：1999-03-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) cause vascular thrombosis (VT) and/or pregnancy morbidity (PM). Differential mechanisms however, underlying the pathogenesis of these different manifestations of antiphospholipid syndrome (APS) are not fully understood. Therefore, we compared the effects of aPL from patients with thro...

journal_title：Journal of autoimmunity

authors： Ripoll VM,Pregnolato F,Mazza S,Bodio C,Grossi C,McDonnell T,Pericleous C,Meroni PL,Isenberg DA,Rahman A,Giles IP

更新日期：2018-09-01 00:00:00

abstract：:Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

journal_title：Journal of autoimmunity

authors： Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

更新日期：2019-07-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by both genetic and environmental factors. Twin and family studies suggest a substantial role for genetic factors in the predispositio...

journal_title：Journal of autoimmunity

authors： Hersh AO,Prahalad S

更新日期：2015-11-01 00:00:00

abstract：:CD4(+) IFN-gamma-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoi...

journal_title：Journal of autoimmunity

authors： Dardalhon V,Korn T,Kuchroo VK,Anderson AC

更新日期：2008-11-01 00:00:00

abstract：:Many mechanisms can explain the mode of action of IVIg in immune disorders. Macrophage blockade and interference in the idiotypic network are supported by some experimental data. Among the other mechanisms, two are considered in greater detail. Firstly, in some disorders, the patients could improve simply because the ...

journal_title：Journal of autoimmunity

authors： Masson PL

更新日期：1993-12-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

journal_title：Journal of autoimmunity

authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

更新日期：2006-11-01 00:00:00

abstract：:The development of autoimmune diseases is characterized by the breakdown of mechanism(s) that are responsible for maintaining immunological tolerance against self-structures in the periphery. Several aberrations of immune cells have been described so far. Most recently quantitative and/or qualitative defects of T cell...

journal_title：Journal of autoimmunity

authors： Scheinecker C,Bonelli M,Smolen JS

更新日期：2010-11-01 00:00:00

abstract：:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain de...

journal_title：Journal of autoimmunity

authors： Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix H

更新日期：1991-04-01 00:00:00

abstract：:Beta(2)-glycoprotein I (beta(2)GPI) is known as a major autoantigen for antiphospholipid antibodies. Our recent data show that binding of beta(2)GPI to oxidized low-density lipoprotein (oxLDL) or to liposomes containing anionic phospholipid(s) may facilitate the presentation of beta(2)GPI's epitope by macrophages/dend...

journal_title：Journal of autoimmunity

authors： Kajiwara T,Yasuda T,Matsuura E

更新日期：2007-09-01 00:00:00

abstract：:To study the expression of protein tyrosine phosphatases (PTPs) in pancreatic islets, a cDNA library from islet cells was constructed and analysed. Twenty-one different PTPs were found to be expressed in islet cells, including three previously unknown PTPs. One of these, IA-2beta, was cloned, sequenced, and found to b...

journal_title：Journal of autoimmunity

authors： Notkins AL,Zhang B,Matsumoto Y,Lan MS

更新日期：1997-06-01 00:00:00

abstract：:Since its description in 1965, Sneddon syndrome (SNS) is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The presence of many other manifestations suggests that it is a systemic syndrome. The prevalence of anti-phospholipid antibodies (aPL) is highly...

journal_title：Journal of autoimmunity

authors： Francès C,Piette JC

更新日期：2000-09-01 00:00:00

abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

journal_title：Journal of autoimmunity

authors： Harbige J,Eichmann M,Peakman M

更新日期：2017-11-01 00:00:00

abstract：:Increasing evidence suggests that immune complexes made of anti-nuclear antibodies bound to nucleosomes released from dead cells play an important role in the pathogenesis of lupus nephritis. However, the nature and composition of apoptotic nucleosomes still remain elusive. Since large amounts of nucleosomes are relea...

journal_title：Journal of autoimmunity

authors： Cabrespines A,Laderach D,Lebossé C,Bach JF,Koutouzov S

更新日期：1998-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown aetiology. Although it has been reported that T cells might be responsible for the pathogenesis of SLE, it remains unclear whether immune aberrations of SLE T cells are the primary event in this pathological process. We have recently report...

journal_title：Journal of autoimmunity

authors： Tsuzaka K,Takeuchi T,Onoda N,Pang M,Abe T

更新日期：1998-10-01 00:00:00

abstract：:A recent report identified two islet cell cytoplasmic antibody subclasses using an immunohistochemical method. The islet cell cytoplasmic antibody subclass which reacts with only Beta-cells was termed 'Beta-cell islet cell cytoplasmic antibodies' and another islet cell cytoplasmic antibody subclass which reacts with B...

journal_title：Journal of autoimmunity

authors： Takino H,Kawasaki E,Yano M,Matsumoto K,Uotani S,Okuno S,Takao Y,Yamasaki H,Yamaguchi Y,Akazawa S

更新日期：1994-06-01 00:00:00