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Role of Th1 and Th17 cells in organ-specific autoimmunity.

Abstract：

:CD4(+) IFN-gamma-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoimmunity. Recently, a new CD4(+) effector T cell subset that produces IL-17 (Th17) has emerged. The fact that Th17 cells are highly auto-pathogenic has fueled a debate as to what role, if any, Th1 cells play in the induction of tissue inflammation and autoimmune disease. This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Dardalhon V,Korn T,Kuchroo VK,Anderson AC

doi

10.1016/j.jaut.2008.04.017

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

252-6

issue

3

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(08)00050-4

journal_volume

31

pub_type

杂志文章,评审

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