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Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis.

Abstract：

:IL-10 has been shown to be an important anti-inflammatory mediator that has both down-regulatory and immunomodulatory effects. Utilizing IL-10(-/-) mice we demonstrate the induction of low dose oral tolerance characterized by the up-regulation of TGF-beta and IL-4 and the suppression of Ag specific proliferation with little suppression of INF-gamma. More severe EAE was found in IL-10(-/-) mice than in wild type controls, however, feeding resulted in amelioration of disease severity in both groups. Orally tolerized IL-10(-/-) mice had greater disease severity compared to orally tolerized wild type mice. IL-4 was present in the GALT of IL-10(-/-) mice and up-regulation of TGF-beta was detected in the lamina propria of fed mice. These results demonstrate that IL-10 is not required for the induction of low dose oral tolerance but is required for the regulation of INF-gamma which affects severity of disease in tolerized mice.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Gonnella PA,Waldner HP,Kodali D,Weiner HL

doi

10.1016/j.jaut.2004.08.001

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

193-200

issue

3

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(04)00089-7

journal_volume

23

pub_type

杂志文章

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