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IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.

Abstract：

:IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum IgA and elevated levels of IgA with rheumatoid factor (RF) activity. IgA-CIC and IgA-RF were more frequent (P less than 0.03 and less than 0.001) in the 27 primary SS patients with, than in the 25 without extraglandular manifestations. IgA-CIC could play a role in mediating the tissue injury associated with primary SS.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Bendaoud B,Pennec YL,Lelong A,Le Noac'h JF,Magadur G,Jouquan J,Youinou P

doi

10.1016/0896-8411(91)90016-6

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

177-84

issue

1

eissn

0896-8411

issn

1095-9157

pii

0896-8411(91)90016-6

journal_volume

4

pub_type

杂志文章

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