Abstract：
:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this predominance. These hypotheses have gained credence mostly because many of these diseases appear or fluctuate when there are hormonal changes such as in late adolescence and pregnancy. Differences in X chromosome characteristics between men and women with an AD have led researchers to think that the genetic background of this group of diseases also relates to the genetic determinants of gender. These hormonal changes as well as the genetic factors that could explain why women are more prone to develop ADs are herein reviewed.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JMdoi
10.1016/j.jaut.2011.10.003subject
Has Abstractpub_date
2012-05-01 00:00:00pages
J109-19issue
2-3eissn
0896-8411issn
1095-9157pii
S0896-8411(11)00106-5journal_volume
38pub_type
杂志文章,评审abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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