N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia.

abstract：:Bullous pemphigoid (BP) and linear IgA disease (LAD) are autoimmune subepidermal blistering skin diseases associated with autoantibodies against the transmembrane hemidesmosomal protein BP180/type XVII collagen. It has been demonstrated previously that BP is characterized predominantly by IgG autoantibodies, while aut...

journal_title：Journal of autoimmunity

authors： Kromminga A,Scheckenbach C,Georgi M,Hagel C,Arndt R,Christophers E,Bröcker EB,Zillikens D

更新日期：2000-11-01 00:00:00

abstract：:There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway. ...

journal_title：Journal of autoimmunity

authors： Michaelson JS,Wisniacki N,Burkly LC,Putterman C

更新日期：2012-09-01 00:00:00

abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

journal_title：Journal of autoimmunity

authors： Simons PJ,Delemarre FG,Drexhage HA

更新日期：2000-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

journal_title：Journal of autoimmunity

authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

更新日期：2013-03-01 00:00:00

abstract：:We have previously demonstrated, in the collagen-induced arthritis model (CIA), that repetitive injections of immature bone-marrow-derived dendritic cells (iDCs) induce the expansion of a population of CD4CD49b-expressing cells, and that their adoptive transfer results in protection against CIA in a prophylactic setti...

journal_title：Journal of autoimmunity

authors： Charbonnier LM,Han WG,Quentin J,Huizinga TW,Zwerina J,Toes RE,Jorgensen C,Louis-Plence P

更新日期：2010-06-01 00:00:00

abstract：:Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprote...

journal_title：Journal of autoimmunity

authors： de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P

更新日期：2000-09-01 00:00:00

abstract：:The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

journal_title：Journal of autoimmunity

authors： Qin K,Han C,Zhang H,Li T,Li N,Cao X

更新日期：2017-07-01 00:00:00

abstract：:Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell com...

journal_title：Journal of autoimmunity

authors： Brennan FM,Chantry D,Jackson AM,Maini RN,Feldmann M

更新日期：1989-06-01 00:00:00

abstract：:Isolated congenital heart block may be associated with autoimmune disorder such as Sjögren Syndrome and systemic lupus erythematosus. In this work we demonstrate circulating autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor (mAChR) in the sera of children with congenital heart block. This anti...

journal_title：Journal of autoimmunity

authors： Borda E,Sterin-Borda L

更新日期：2001-03-01 00:00:00

abstract：:Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

journal_title：Journal of autoimmunity

authors： Kamei H

更新日期：2004-05-01 00:00:00

abstract：:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...

journal_title：Journal of autoimmunity

authors： Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JM

更新日期：2012-05-01 00:00:00

abstract：:Natural autoantibodies (autoNAb) recognize self antigens and are an important component of the immune system, as species ranging from invertebrates to vertebrates have polyreactive IgM NAbs. In higher vertebrates, different polyreactive autoNAbs isotypes are also frequently encountered and autopolyreactive IgG NAbs ar...

journal_title：Journal of autoimmunity

authors： Avrameas S,Selmi C

更新日期：2013-03-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is defined as a chronic liver inflammation with loss of tolerance against hepatocytes. The etiology and pathophysiology of AIH are still poorly understood because reliable animal models are limited. Therefore, we recently introduced a model of experimental murine AIH by a self-limited adenov...

journal_title：Journal of autoimmunity

authors： Hardtke-Wolenski M,Dywicki J,Fischer K,Hapke M,Sievers M,Schlue J,Anderson MS,Taubert R,Noyan F,Manns MP,Jaeckel E

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. METHODS:Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compare...

journal_title：Journal of autoimmunity

authors： Leclercq M,Langlois V,Girszyn N,Le Besnerais M,Benhamou Y,Levesque H,Muraine M,Gueudry J

更新日期：2020-09-01 00:00:00

abstract：:GAD65 (glutamic acid decarboxylase) is an important autoantigen in both type 1 (insulin-dependent) diabetes mellitus (IDDM) and the neurological autoimmune disease stiff-man syndrome (SMS), and is expressed in pancreatic islets as well as the nervous system. Still, only 30% of SMS patients also have type 1 diabetes. T...

journal_title：Journal of autoimmunity

authors： Schloot NC,Batstra MC,Duinkerken G,De Vries RR,Dyrberg T,Chaudhuri A,Behan PO,Roep BO

更新日期：1999-06-01 00:00:00

abstract：:Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules in the B7 superfamily. Inducible costimulator (ICOS), the receptor for B7h (also known as B7RP-1), is expressed on T cells after T cell activation. Recently, using ICOS-def...

journal_title：Journal of autoimmunity

authors： Dong C,Nurieva RI

更新日期：2003-11-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

journal_title：Journal of autoimmunity

authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

更新日期：1990-12-01 00:00:00

abstract：:Helper T cells are required for development of the autoantibody responses to native mouse erythrocytes (MRBC) that spontaneously develop in NZB mice. However, the stimulus for these Th is not known. Therefore, we compared the abilities of splenic T cells from actively autoimmune old NZB mice and preautoimmune, young N...

journal_title：Journal of autoimmunity

authors： Calkins CE,Esposito M

更新日期：1996-08-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：:T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu...

journal_title：Journal of autoimmunity

authors： Chang JC,Linarelli LG,Laxer JA,Froning KJ,Caralli LL,Brostoff SW,Carlo DJ

更新日期：1995-04-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

journal_title：Journal of autoimmunity

authors： Pearson JA,Wong FS,Wen L

更新日期：2016-01-01 00:00:00

abstract：:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against th...

journal_title：Journal of autoimmunity

authors： Mobini R,Staudt A,Felix SB,Baumann G,Wallukat G,Deinum J,Svensson H,Hjalmarson A,Fu M

更新日期：2003-06-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by both genetic and environmental factors. Twin and family studies suggest a substantial role for genetic factors in the predispositio...

journal_title：Journal of autoimmunity

authors： Hersh AO,Prahalad S

更新日期：2015-11-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：:Among B/W-derived IgM mAb, 12.5H was selected because of its ability to recognize, in solid phase ELISAs, IgG mAb with DNA-binding activity. mAb 12.5H bound preferentially to IgG2a mAb and did not react with B/W- or BALB/c-derived IgG2a mAb with no DNA-binding activity, suggesting V region-mediated interactions. mAb 1...

journal_title：Journal of autoimmunity

authors： Margaritte C,Gilbert D,Brard F,Tron F

更新日期：1994-12-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

journal_title：Journal of autoimmunity

authors： Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

更新日期：2001-09-01 00:00:00

abstract：:It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

journal_title：Journal of autoimmunity

authors： Harvey HA,Swords WE,Apicella MA

更新日期：2001-05-01 00:00:00

abstract：:To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibi...

journal_title：Journal of autoimmunity

authors： Vento S,McFarlane BM,Vento TG,Ranieri S,Rondanelli EG,McFarlane IG,Williams R,Eddleston AL

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVES:Sicca symptoms occur in around 30% of rheumatoid arthritis (RA) patients. Herein, we examined the characteristics of RA patients bearing sicca symptomatology (RA-sicca) with a special focus on the immunohistopathological features of their labial minor salivary gland (LMSG) biopsies. METHODS:Our cohort inclu...

journal_title：Journal of autoimmunity

authors： Fragoulis GE,Fragkioudaki S,Reilly JH,Kerr SC,McInnes IB,Moutsopoulos HM

更新日期：2016-09-01 00:00:00