N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia.


:We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotocin. The macrosomic (MAC) offspring were sacrificed at the age of 90 days. The mRNAs of IL-2 and IFN-gamma (Th1 cytokines) and IL-4 (Th2 cytokine) were downregulated in the pancreas and spleen of diabetic pregnant rats. The levels of IL-10 mRNA, another Th2 cytokine, were unchanged in the spleen or upregulated in the pancreas of these animals. Feeding an n-3 PUFA diet to rats with DP upregulated IL-10 mRNA in the pancreas and IL-4 and IL-10 mRNA in the spleen. In MAC offspring, high expression of IL-2 and IFN-gamma mRNA, but not of Th2 cytokines, was observed. The n-3 PUFA diet diminished Th1 mRNA quantities and increased the levels of IL-4, but not of IL-10, mRNA in MAC offspring. Our study shows that DP is associated with a decreased Th1 phenotype and IL-4 mRNA expression in the pancreas and spleen, and an n-3 PUFA diet upregulates Th2 profile. In MAC offspring, the Th1 phenotype is upregulated and an n-3 PUFA diet downregulates this phenomenon.


J Autoimmun


Journal of autoimmunity


Khan NA,Yessoufou A,Kim M,Hichami A




Has Abstract


2006-06-01 00:00:00














  • B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia.

    abstract::B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

    更新日期:2017-02-01 00:00:00

  • Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

    abstract::Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Bonam SR,Wang F,Muller S

    更新日期:2018-11-01 00:00:00

  • The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.

    abstract::It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Harvey HA,Swords WE,Apicella MA

    更新日期:2001-05-01 00:00:00

  • Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome.

    abstract::Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Chighizola CB,Pregnolato F,Andreoli L,Bodio C,Cesana L,Comerio C,Gerosa M,Grossi C,Kumar R,Lazzaroni MG,Mahler M,Mattia E,Nalli C,Norman GL,Raimondo MG,Ruffatti A,Tonello M,Trespidi L,Tincani A,Borghi MO,Meroni PL

    更新日期:2018-06-01 00:00:00

  • Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction.

    abstract::Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

    更新日期:2007-06-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.

    abstract::We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

    更新日期:1995-10-01 00:00:00

  • Inappropriate expression of HLA class II molecules in endocrine epithelial cells: the phenomenon, the new experimental data and comparison with animal models.

    abstract::Physiologically, HLA Class II molecules are primarily expressed on immunoregulatory cells. In recent years, it has been shown that tissues affected by autoimmunity, including beta cells of 'diabetic' pancreases, 'inappropriately' express these glycoproteins. Cytokines are potent Class II inducers on a variety of cells...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Pujol-Borrell R,Soldevila G,Buscema M,Vives M,Badenas J,Marakian R,Bottazzo GF

    更新日期:1989-06-01 00:00:00

  • Autoantibody repertoire to Ro/SSA and La/SSB antigens in patients with primary and secondary Sjögren's syndrome.

    abstract::Autoimmune diseases are characterized serologically by the presence of antibodies to specific autoantigens. Antibodies to the two antigens Ro/SSA and La/SSB are found in patients with primary (pSS) and secondary Sjögren's syndrome (sSS). To explore if differences in the fine specificity of these autoantibodies could b...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Wahren M,Solomin L,Pettersson I,Isenberg D

    更新日期:1996-08-01 00:00:00

  • In vitro induction of regulatory T cells by anti-CD3 antibody in humans.

    abstract::Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4(+) T cells were stimulated with plate-bound anti-CD3 and cultured for 12 days after which they ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Abraham M,Karni A,Dembinsky A,Miller A,Gandhi R,Anderson D,Weiner HL

    更新日期:2008-02-01 00:00:00

  • Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

    abstract::Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Chu CQ,Londei M

    更新日期:1999-02-01 00:00:00

  • Personality structure disturbances and psychiatric manifestations in primary Sjögren's syndrome.

    abstract::It has been recently suggested that primary Sjögren's syndrome (SS) patients present with a variety of personality structure disturbances and psychiatric symptoms. To evaluate this finding further, we assessed hostility structure and psychiatric symptoms in 33 Sjögren's syndrome patients and compared the results with ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Drosos AA,Angelopoulos NV,Liakos A,Moutsopoulos HM

    更新日期:1989-08-01 00:00:00

  • High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice.

    abstract::Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Badami E,Maiuri L,Quaratino S

    更新日期:2005-03-01 00:00:00

  • Regulation of immune and autoimmune responses by ICOS.

    abstract::Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules in the B7 superfamily. Inducible costimulator (ICOS), the receptor for B7h (also known as B7RP-1), is expressed on T cells after T cell activation. Recently, using ICOS-def...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Dong C,Nurieva RI

    更新日期:2003-11-01 00:00:00

  • Immunogenetics of juvenile idiopathic arthritis: A comprehensive review.

    abstract::Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by both genetic and environmental factors. Twin and family studies suggest a substantial role for genetic factors in the predispositio...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Hersh AO,Prahalad S

    更新日期:2015-11-01 00:00:00

  • Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis.

    abstract::Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient with PBC with the mouse human heterohybrid cell line F3B6. Previ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Leung PS,Krams S,Munoz S,Surh CP,Ansari A,Kenny T,Robbins DL,Fung J,Starzl TE,Maddrey W

    更新日期:1992-12-01 00:00:00

  • Glutamic acid decarboxylase 65 and 67 isoforms in fetal, neonatal and adult porcine islets: predominant beta cell co-localization by light and confocal microscopy.

    abstract::Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Reddy S,Wu D,Poole CA

    更新日期:1996-02-01 00:00:00

  • Autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity.

    abstract::A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JM

    更新日期:2012-05-01 00:00:00

  • Post-thymic tolerance to self antigens.

    abstract::There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Miller JF

    更新日期:1992-04-01 00:00:00

  • Immunological monitoring in organ transplantation and autoimmune disease.

    abstract::The clinical manifestations of graft rejection or autoimmune disease represent the terminal phase in a complex sequence of inflammatory events. Although the spectrum of response to injury within each tissue is normally narrowly defined, the immune mechanisms involved may be heterogeneous, influenced by the immune stat...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Keown PA

    更新日期:1992-04-01 00:00:00

  • Gender as risk factor for autoimmune diseases.

    abstract::Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Gleicher N,Barad DH

    更新日期:2007-02-01 00:00:00

  • Sjögren's syndrome salivary gland immunopathology: increased laminin expression precedes lymphocytic infiltration.

    abstract::Previous studies have demonstrated increased expression of a laminin-like protein in labial salivary glands from Sjögren's syndrome (SS) patients. The objective of the present study was to verify the identity of this protein and to compare lymphocytic infiltration and laminin expression in minor salivary gland ductal ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: McArthur CP,Daniels PJ,Kragel P,Howard PF,Julian L

    更新日期:1997-02-01 00:00:00

  • Cellular immune responses and pathogenesis in c-ANCA positive vasculitides.

    abstract::Very little is known about the cellular immune response in c-ANCA (classical anti-neutrophil cytoplasm antibodies) positive vasculitides or Wegener's granulomatosis (WG). The present review is mainly based on published and unpublished observations of the Cattegat Study Group of Wegener's Granulomatosis. Immunohistoche...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Rasmussen N,Petersen J

    更新日期:1993-04-01 00:00:00

  • Lack of relationship between the Epstein-Barr virus and the antiperinuclear factor/'perinuclear antigen' system in rheumatoid arthritis.

    abstract::Our purpose was to evaluate the role of Epstein-Barr virus (EBV) in the production of antiperinuclear factor (APF), a rheumatoid arthritis (RA)-specific marker, and the autoimmunogenicity of 'perinuclear antigens' (PNA) found within the buccal mucosa epithelial cells used as a substrate in the APF assay. Fifty APF-pos...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Buisson M,Berthelot JM,Le Goff P,Chastel C,Lamour A,Seigneurin JM,Youinou P

    更新日期:1994-08-01 00:00:00

  • Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation.

    abstract::Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

    更新日期:2003-03-01 00:00:00

  • Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.

    abstract::Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

    更新日期:2014-05-01 00:00:00

  • Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.

    abstract::Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

    更新日期:2000-02-01 00:00:00

  • Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: the significance of the intra-bone marrow injection.

    abstract::The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Sonoda Y

    更新日期:2008-05-01 00:00:00

  • The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.

    abstract::HLA-DQB1 is widely considered to be the major histocompatibility complex (MHC) susceptibility gene for type 1 diabetes (T1D). However, since inheritance of the gene in T1D is recessive, the presence of the protective HLA-DQB1 0602 allele with normal nucleotide sequence in some patients raises the question of whether H...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Husain Z,Kelly MA,Eisenbarth GS,Pugliese A,Awdeh ZL,Larsen CE,Alper CA

    更新日期:2008-06-01 00:00:00

  • From old concerns to new advances and personalized medicine in lupus: The end of the tunnel is approaching.

    abstract::The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the...

    journal_title:Journal of autoimmunity

    pub_type: 社论,评审


    authors: Doria A,Gershwin ME,Selmi C

    更新日期:2016-11-01 00:00:00

  • A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production.

    abstract::A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recogniti...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Stiemer RH,Westenfelder U,Gausepohl H,Mirshahi M,Gundt A,Frank RW,Männel DN

    更新日期:1992-02-01 00:00:00