当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

Abstract：

:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully understood. Here, we demonstrate that conditional ablation of DCs during the priming phase of myelin-specific T cells in experimental autoimmune encephalomyelitis (EAE) selectively aborts inducible Treg (iTreg) induction, whereas generation of T helper (Th)1/17 cells is unaltered. DCs facilitate iTreg induction by creating a milieu with high levels of interleukin (IL)-2 due to a strong proliferative response. In the absence of DCs, B220+ B cells take over priming of Th17 cells in the place of antigen-presenting cells (APCs), but not the induction of iTreg, thus leading to unregulated, severe autoimmunity.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

doi

10.1016/j.jaut.2016.09.008

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

108-114

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(16)30155-X

journal_volume

76

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.

    abstract：:Glutamic acid decarboxylase 65 (GAD65) is a putative autoantigen associated with the pathogenesis of type 1 diabetes (T1D). The prevalence of autoreactive CD4+ T cells towards the immunodominant GAD65(555-567) epitope in DR4 healthy and T1D subjects was investigated with class II tetramers. A slightly higher percentag...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2005.08.007

    authors： Danke NA,Yang J,Greenbaum C,Kwok WW

    更新日期：2005-12-01 00:00:00

  • Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.

    abstract：:Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaut.2019.04.005

    authors： Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

    更新日期：2019-07-01 00:00:00

  • Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.

    abstract：:Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2008.08.009

    authors： Liu Z,Sui W,Zhao M,Li Z,Li N,Thresher R,Giudice GJ,Fairley JA,Sitaru C,Zillikens D,Ning G,Marinkovich MP,Diaz LA

    更新日期：2008-12-01 00:00:00

  • The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.

    abstract：:Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2015.08.019

    authors： Pearson JA,Wong FS,Wen L

    更新日期：2016-01-01 00:00:00

  • Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2011.11.001

    authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

    更新日期：2012-05-01 00:00:00

  • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

    abstract：:IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0057

    authors： Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

    更新日期：1996-06-01 00:00:00

  • 1,25 dihydroxyvitamin-D3 regulation of immunoglobulin production in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

    abstract：:Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the secretion of autoantibodies. The mechanisms of autoantibody-induced disease have not been clarified. 1,25-Dihydroxy-vitamin D3 (1,25-D3) is known to be important in the regulation of normal human lymphocyte functions. Among...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90012-7

    authors： Chong PJ,Matzner WL,Wallace DJ,Klinenberg JR,Toyoda M,Jordan SC

    更新日期：1989-12-01 00:00:00

  • Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes.

    abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2018.08.004

    authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

    更新日期：2019-01-01 00:00:00

  • Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells.

    abstract：:Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to explain increased UVB-induced inflammation remain unclear. This paper compares the role...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.06.002

    authors： Wolf SJ,Estadt SN,Theros J,Moore T,Ellis J,Liu J,Reed TJ,Jacob CO,Gudjonsson JE,Kahlenberg JM

    更新日期：2019-09-01 00:00:00

  • Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

    abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.12.004

    authors： Ge X,James EA,Reijonen H,Kwok WW

    更新日期：2011-03-01 00:00:00

  • IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes.

    abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.09.005

    authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

    更新日期：2004-12-01 00:00:00

  • In vitro induction of regulatory T cells by anti-CD3 antibody in humans.

    abstract：:Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4(+) T cells were stimulated with plate-bound anti-CD3 and cultured for 12 days after which they ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2007.11.007

    authors： Abraham M,Karni A,Dembinsky A,Miller A,Gandhi R,Anderson D,Weiner HL

    更新日期：2008-02-01 00:00:00

  • Obstetric management of antiphospholipid syndrome.

    abstract：:The obstetric management of women with antiphospholipid (aPL) syndrome remains controversial. Despite recent advances, the controversies have been fueled by our limited understanding of the multi-factorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. We have escaped from the na...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0417

    authors： Rai R

    更新日期：2000-09-01 00:00:00

  • Genomic analysis of collagen and endogenous virus loci in the UCD-200 and 206 lines of chickens, animal models for scleroderma.

    abstract：:University of California at Davis (UCD) lines 200 and 206 chickens develop a hereditary systemic scleroderma-like connective tissue disease characterized by severe lymphocytic infiltration and excessive accumulation of collagen in skin and internal organs. The immune system seems to play an important role in the devel...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1995.0057

    authors： Sgonc R,Dietrich H,Gershwin ME,Colombatti A,Wick G

    更新日期：1995-10-01 00:00:00

  • Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.

    abstract：:To study the expression of protein tyrosine phosphatases (PTPs) in pancreatic islets, a cDNA library from islet cells was constructed and analysed. Twenty-one different PTPs were found to be expressed in islet cells, including three previously unknown PTPs. One of these, IA-2beta, was cloned, sequenced, and found to b...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0132

    authors： Notkins AL,Zhang B,Matsumoto Y,Lan MS

    更新日期：1997-06-01 00:00:00

  • Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice.

    abstract：:Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS has both, a genetic and an environmental predisposition. Among all the genetic factors associated with MS susceptibility, HLA class II haplotypes such as DR2/DQ6, DR3/DQ2, and DR4/DQ8 show the strongest association. Although a direct ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2011.05.001

    authors： Luckey D,Bastakoty D,Mangalam AK

    更新日期：2011-09-01 00:00:00

  • New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

    abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2017.08.001

    authors： Harbige J,Eichmann M,Peakman M

    更新日期：2017-11-01 00:00:00

  • The diagnosis and classification of polymyositis.

    abstract：:Polymyositis is classified as a separate entity among idiopathic inflammatory myopathies but it is considered as the least common since it is an exclusion diagnosis. This myopathy usually presents with subacute-chronic symmetric proximal limb weakness, although some extramuscular manifestations are common. Creatine ki...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.01.025

    authors： Milisenda JC,Selva-O'Callaghan A,Grau JM

    更新日期：2014-02-01 00:00:00

  • Inhibition of the development of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by in vivo treatment with anti-CD4 or anti-CD8 antibodies.

    abstract：:The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0185

    authors： Cihak J,Hoffmann-Fezer G,Wasl M,Merkle H,Kaspers B,Vainio O,Plachý J,Hála K,Wick G,Stangassinger M,Lösch U

    更新日期：1998-04-01 00:00:00

  • E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients.

    abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.01.004

    authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

    更新日期：2013-03-01 00:00:00

  • Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the "CAPS Registry".

    abstract：OBJECTIVE:To describe the clinical and laboratory features, as well as the precipitating factors, treatment and outcome of patients with catastrophic antiphospholipid syndrome (APS). METHODS:We analyzed the 280 patients included until September 2008 in the website based international registry of patients with catastro...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.02.008

    authors： Cervera R,Bucciarelli S,Plasín MA,Gómez-Puerta JA,Plaza J,Pons-Estel G,Shoenfeld Y,Ingelmo M,Espinos G,Catastrophic Antiphospholipid Syndrome (CAPS) Registry Project Group (European Forum On Antiphospholipid Antibodies).

    更新日期：2009-05-01 00:00:00

  • Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha- producing cells.

    abstract：:Systemic lupus erythematosus (SLE) patients often have continuous production of interferon-alpha (IFN-alpha), but production of in vitro IFN-alpha by peripheral blood mononuclear cells (PBMC) may be varyingly reduced. We here report that IFN-alpha production induced by Herpes simplex virus (HSV) in PBMC resembling imm...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0215

    authors： Cederblad B,Blomberg S,Vallin H,Perers A,Alm GV,Rönnblom L

    更新日期：1998-10-01 00:00:00

  • Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.

    abstract：:Epitope spreading is an important mechanism for the development of autoantibodies (autoAbs) in autoimmune diseases. The study of epitope spreading in human autoimmune diseases is limited due to the major challenge of identifying the initial/primary target epitopes on autoantigens in autoimmune diseases. We have been s...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102561

    authors： Peng B,Temple BR,Yang J,Geng S,Culton DA,Qian Y

    更新日期：2021-01-01 00:00:00

  • Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1.

    abstract：:Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0531

    authors： Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

    更新日期：2001-09-01 00:00:00

  • T-cell reactivity in myasthenia gravis.

    abstract：:In a proliferation assay, peripheral blood lymphocytes (PBL) from a relatively small proportion of myasthenia gravis (MG) patients and from controls responded to Torpedo acetylcholine receptor (T-AChR), which shows approximately 75% homology with the human AChR. Over 50% of MG patients responded to recombinant human A...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90121-2

    authors： Newsom-Davis J,Harcourt G,Sommer N,Beeson D,Willcox N,Rothbard JB

    更新日期：1989-06-01 00:00:00

  • A functional and phenotypic study on immune accessory cells isolated from the thyroids of Wistar and autoimmune-prone BB-DP rats.

    abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2000.0438

    authors： Simons PJ,Delemarre FG,Drexhage HA

    更新日期：2000-12-01 00:00:00

  • Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis.

    abstract：:IL-10 has been shown to be an important anti-inflammatory mediator that has both down-regulatory and immunomodulatory effects. Utilizing IL-10(-/-) mice we demonstrate the induction of low dose oral tolerance characterized by the up-regulation of TGF-beta and IL-4 and the suppression of Ag specific proliferation with ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.08.001

    authors： Gonnella PA,Waldner HP,Kodali D,Weiner HL

    更新日期：2004-11-01 00:00:00

  • Effects of anti-B7 monoclonal antibodies on humoral immune responses.

    abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0258

    authors： Daikh DI,Wofsy D

    更新日期：1999-03-01 00:00:00

  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

    abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102462

    authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

    更新日期：2020-08-01 00:00:00

  • Cell adhesion molecules: a selective therapeutic target for alleviation of IDDM.

    abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1069

    authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

    更新日期：1994-12-01 00:00:00