当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

Abstract：

:Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD protein subunit of the lupus-specific Sm autoantigen. Precipitating SmD-specific IgGs were eluted from native SmD-coated ELISA plates preincubated with sera from six patients with systemic lupus erythematosus (SLE) positive for anti-Sm/RNP. Heavy (H)- and light (L)-chain clonality and V-region sequences were analysed by 2-dimensional gel electrophoresis and combined de novo database mass spectrometric sequencing. SmD autoantibody proteomes from all six patients with SLE expressed IgG1 kappa restricted clonotypes specified by IGHV3-7 and IGHV1-69 H-chains and IGKV3-20 and IGKV2-28 L-chains, with shared and individual V-region amino acid replacement mutations. Clonotypic sharing and restricted V-region diversity of systemic autoimmunity can now be extended from the Ro/La cluster to Sm autoantigen and implies a common pathway of anti-Sm autoantibody production in unrelated patients with SLE.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

doi

10.1016/j.jaut.2014.12.005

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

77-81

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(14)00184-X

journal_volume

57

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Antigen based therapies to prevent diabetes in NOD mice.

    abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0047

    authors： Ramiya VK,Shang XZ,Pharis PG,Wasserfall CH,Stabler TV,Muir AB,Schatz DA,Maclaren NK

    更新日期：1996-06-01 00:00:00

  • The immune milieu of cholangiocarcinoma: From molecular pathogenesis to precision medicine.

    abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2019.03.007

    authors： Rimassa L,Personeni N,Aghemo A,Lleo A

    更新日期：2019-06-01 00:00:00

  • Primary immunodeficiency and autoimmunity: A comprehensive review.

    abstract：:The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved methods of detection and advanced laboratory methodology. Patients with PIDs have an increased...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2019.01.011

    authors： Amaya-Uribe L,Rojas M,Azizi G,Anaya JM,Gershwin ME

    更新日期：2019-05-01 00:00:00

  • cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.

    abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.03.001

    authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

    更新日期：2019-06-01 00:00:00

  • Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice.

    abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2002.0619

    authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

    更新日期：2002-12-01 00:00:00

  • IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.

    abstract：:IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(91)90016-6

    authors： Bendaoud B,Pennec YL,Lelong A,Le Noac'h JF,Magadur G,Jouquan J,Youinou P

    更新日期：1991-02-01 00:00:00

  • The effect of B-cell depletion therapy on serological evidence of B-cell and plasmablast activation in patients with rheumatoid arthritis over multiple cycles of rituximab treatment.

    abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.12.002

    authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

    更新日期：2014-05-01 00:00:00

  • Lack of proliferative response by gluten-specific T cells in the blood and gut of patients with dermatitis herpetiformis.

    abstract：:The majority of patients with Dermatitis Herpetiformis (DH) have a gluten-sensitive enteropathy which may be triggered by a T cell-mediated immune response to gluten. Using a proliferative assay, the responses to gluten fraction III, recall antigens and mitogens of peripheral blood mononuclear cells (PBMC) and gut T c...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(95)90008-x

    authors： Baker BS,Garioch JJ,Bokth S,Thomas H,Walker MM,Leonard JN,Fry L

    更新日期：1995-08-01 00:00:00

  • Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study.

    abstract：:In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0360

    authors： Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

    更新日期：2000-03-01 00:00:00

  • Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study.

    abstract：:Primary biliary cirrhosis (PBC) sera contain antibodies which recognize various nuclear envelope proteins of which antibody against gp210 has been proven to be diagnostic for disease. In contrast, the clinical significance of another nuclear envelope antibody, anti-p62 antibody has not been well investigated. In the p...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0896-8411(03)00033-7

    authors： Miyachi K,Hankins RW,Matsushima H,Kikuchi F,Inomata T,Horigome T,Shibata M,Onozuka Y,Ueno Y,Hashimoto E,Hayashi N,Shibuya A,Amaki S,Miyakawa H

    更新日期：2003-05-01 00:00:00

  • Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

    abstract：OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.04.001

    authors： Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

    更新日期：2019-07-01 00:00:00

  • Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients.

    abstract：:Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sjögren's syndrome patients (SS)-patients show signs of inflammation and altered proteostasis, associated with low IRE1α/XBP-1 pathway a...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.07.006

    authors： Barrera MJ,Aguilera S,Castro I,Cortés J,Bahamondes V,Quest AFG,Molina C,González S,Hermoso M,Urzúa U,Leyton C,González MJ

    更新日期：2016-12-01 00:00:00

  • Immunoblotting for the detection of TSH receptor autoantibodies.

    abstract：:Immunoblotting was optimized to detect autoantibodies to TSH receptors from human and porcine thyroid tissue and to determine their epitope specificity. Autoantibodies to putative TSH receptor proteins in thyroid particulate membranes were detected in approximately 35% of sera from patients with Graves' disease. Howev...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(91)90164-8

    authors： Leedman PJ,Harrison PJ,Harrison LC

    更新日期：1991-06-01 00:00:00

  • IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes.

    abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.09.005

    authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

    更新日期：2004-12-01 00:00:00

  • Polymyalgia rheumatica--diagnosis and classification.

    abstract：:Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.01.016

    authors： Nesher G

    更新日期：2014-02-01 00:00:00

  • Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies.

    abstract：:Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly understood preclinical stage of immune dysregulation and symptom accrual. Accumulation of antinuclear autoantibody (ANA) specificities is a hallmark of impending clinical disease. Yet, many ANA-positive individuals remain healthy, suggest...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.06.001

    authors： Lu R,Munroe ME,Guthridge JM,Bean KM,Fife DA,Chen H,Slight-Webb SR,Keith MP,Harley JB,James JA

    更新日期：2016-11-01 00:00:00

  • Characterization of two anti-DNA antibodies bearing distinct idiotypes. Correlation with clinical manifestations.

    abstract：:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90271-0

    authors： Suenaga R,Munoz PA,Hon SH,Abdou NI

    更新日期：1989-06-01 00:00:00

  • Effects of anti-B7 monoclonal antibodies on humoral immune responses.

    abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0258

    authors： Daikh DI,Wofsy D

    更新日期：1999-03-01 00:00:00

  • Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities.

    abstract：:The probability that epitope spreading occurs in multiple sclerosis (MS) and the fact that patients have been shown to respond to multiple myelin epitopes concurrently makes the use of peptide-specific tolerance therapies targeting single epitopes problematic. To attempt to overcome this limitation, we have employed c...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.12.002

    authors： Smith CE,Miller SD

    更新日期：2006-12-01 00:00:00

  • T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients.

    abstract：:Myasthenia gravis (MG) is a prototypical antibody-mediated disease characterized by muscle weakness and fatigability. Serum antibodies to the acetylcholine receptor and muscle-specific tyrosine kinase receptor (MuSK) are found in about 85% and 8% of patients respectively. We have previously shown that more than 70% of...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.12.007

    authors： Marino M,Maiuri MT,Di Sante G,Scuderi F,La Carpia F,Trakas N,Provenzano C,Zisimopoulou P,Ria F,Tzartos SJ,Evoli A,Bartoccioni E

    更新日期：2014-08-01 00:00:00

  • B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia.

    abstract：:B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.11.002

    authors： Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

    更新日期：2017-02-01 00:00:00

  • Immune tolerance: what is unique about the liver.

    abstract：:The 'liver tolerance effect' mediates local and systemic tolerance to self and foreign antigens and has been attributed to specialized resident cells expressing anti-inflammatory mediators and inhibitory cell surface ligands for T cell activation. Non-parenchymal liver cells responsible for the tolerogenic properties ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2009.08.008

    authors： Tiegs G,Lohse AW

    更新日期：2010-02-01 00:00:00

  • Cardiac dysfunction in murine autoimmune myocarditis.

    abstract：:We have investigated the pathophysiological basis of cardiac dysfunction in autoimmune myocarditis and in the resulting dilated cardiomyopathy. To this end we utilized the myosin-induced autoimmune myocarditis model in BALB/c mice. Myocarditis has been found to be associated with massive ventricular lymphocyte infiltr...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0273

    authors： Less H,Shilkrut M,Rubinstein I,Berke G,Binah O

    更新日期：1999-05-01 00:00:00

  • Juvenile autoimmune hepatitis: A comprehensive review.

    abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2018.10.007

    authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

    更新日期：2018-12-01 00:00:00

  • Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation.

    abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an increasingly widely used treatment modality in hematological malignancies. Alloreactivity mediated by donor T cells (and, in some settings, by donor natural killer cells) can produce durable immunologic control or eradication of residual malignancy after alloge...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.002

    authors： Rezvani AR,Storb RF

    更新日期：2008-05-01 00:00:00

  • Autoantibodies from Sjögren's syndrome induce activation of both the intrinsic and extrinsic apoptotic pathways in human salivary gland cell line A-253.

    abstract：:Sjögren's syndrome (SS) is an autoimmune rheumatic disease that targets salivary and lachrymal glands, characterized by a high concentration of serum autoantibodies directed against nuclear and cytoplasmic antigens. It is known that autoantibodies can enter viable cells and this phenomenon has functional consequences ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.05.001

    authors： Sisto M,Lisi S,Castellana D,Scagliusi P,D'Amore M,Caprio S,Scagliusi A,Acquafredda A,Panaro MA,Mitolo V

    更新日期：2006-08-01 00:00:00

  • Autoimmunity: from black water fever to regulatory function.

    abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

    journal_title：Journal of autoimmunity

    pub_type： 社论,历史文章

    doi：10.1016/j.jaut.2013.12.019

    authors： Chang C

    更新日期：2014-02-01 00:00:00

  • Limiting dilution analysis of Epstein-Barr virus infectable B cells secreting anti-Ro/SSA and anti-La/SSB antibodies in neonatal lupus erythematosus and systemic lupus erythematosus.

    abstract：:Neonatal lupus erythematosus (NLE) is associated with the transplacental passage of maternal anti-Ro and anti-La antibodies. In order to better determine the risk of delivery of a child with NLE, we examined the frequency of anti-Ro and anti-La antibody secreting cells in mothers of children with NLE and in mothers at...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1993.1040

    authors： Isacovics B,Silverman ED

    更新日期：1993-08-01 00:00:00

  • Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma.

    abstract：:University of California at Davis line 200 (UCD-200) chickens develop a hereditary connective tissue disease characterized by severe lymphocytic infiltration, vascular occlusion and fibrosis of skin and internal organs. To identify cellular immunological abnormalities in the acute inflammatory disease stage of this an...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(91)90178-f

    authors： Gruschwitz MS,Moormann S,Krömer G,Sgonc R,Dietrich H,Boeck G,Gershwin ME,Boyd R,Wick G

    更新日期：1991-08-01 00:00:00

  • T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice.

    abstract：:The great majority of insulin-specific T cell clones isolated from islets of NOD mice react with insulin peptide B-(9-23) (amino acids 9-23 of the insulin B chain). The T cell receptors of these clones contain diverse beta-chains but restricted alpha-chains. The dominant alpha-chain motif is a V alpha 13 segment (10 o...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0134

    authors： Simone EA,Yu L,Wegmann DR,Eisenbarth GS

    更新日期：1997-06-01 00:00:00