Lack of relationship between the Epstein-Barr virus and the antiperinuclear factor/'perinuclear antigen' system in rheumatoid arthritis.

abstract：:We have previously demonstrated, in the collagen-induced arthritis model (CIA), that repetitive injections of immature bone-marrow-derived dendritic cells (iDCs) induce the expansion of a population of CD4CD49b-expressing cells, and that their adoptive transfer results in protection against CIA in a prophylactic setti...

journal_title：Journal of autoimmunity

authors： Charbonnier LM,Han WG,Quentin J,Huizinga TW,Zwerina J,Toes RE,Jorgensen C,Louis-Plence P

更新日期：2010-06-01 00:00:00

abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

journal_title：Journal of autoimmunity

authors： Derksen RH,de Groot PG

更新日期：2000-09-01 00:00:00

abstract：:The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients ...

journal_title：Journal of autoimmunity

authors： Amador-Patarroyo MJ,Arbelaez JG,Mantilla RD,Rodriguez-Rodriguez A,Cárdenas-Roldán J,Pineda-Tamayo R,Guarin MR,Kleine LL,Rojas-Villarraga A,Anaya JM

更新日期：2012-09-01 00:00:00

abstract：:Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We...

journal_title：Journal of autoimmunity

authors： Alarcón-Riquelme ME,Prokunina L

更新日期：2003-09-01 00:00:00

abstract：:(Beta2-glycoprotein I (beta2GPI) is a plasma protein that plays an important role in the antigenic specificity of antiphospholipid autoantibodies (aPL). These antibodies are associated with an increased risk for thrombosis and recurrent foetal loss in humans. Crystallographic analysis of beta2GPI showed that its five ...

journal_title：Journal of autoimmunity

authors： Iverson GM,Matsuura E,Victoria EJ,Cockerill KA,Linnik MD

更新日期：2002-06-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

journal_title：Journal of autoimmunity

authors： Pearson JA,Wong FS,Wen L

更新日期：2016-01-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by both genetic and environmental factors. Twin and family studies suggest a substantial role for genetic factors in the predispositio...

journal_title：Journal of autoimmunity

authors： Hersh AO,Prahalad S

更新日期：2015-11-01 00:00:00

abstract：:Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules in the B7 superfamily. Inducible costimulator (ICOS), the receptor for B7h (also known as B7RP-1), is expressed on T cells after T cell activation. Recently, using ICOS-def...

journal_title：Journal of autoimmunity

authors： Dong C,Nurieva RI

更新日期：2003-11-01 00:00:00

abstract：:The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

journal_title：Journal of autoimmunity

authors： Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of biosimilars of anti-tumor necrosis factor (TNF)-α agents compared to their reference agents in immune mediated diseases. METHODS:Electronic databases were searched for randomized controlled trials (RCTs) assessing the efficacy and safety of biosimilars of anti-TNF-α age...

journal_title：Journal of autoimmunity

authors： Komaki Y,Yamada A,Komaki F,Kudaravalli P,Micic D,Ido A,Sakuraba A

更新日期：2017-05-01 00:00:00

abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

journal_title：Journal of autoimmunity

authors： Chu CQ,Londei M

更新日期：1999-02-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APC) with significant phenotypic heterogeneity and functional plasticity. DCs play crucial roles in initiating effective adaptive immune responses for elimination of invading pathogens and also in inducing immune tolerance toward harmless components to m...

journal_title：Journal of autoimmunity

authors： Liu J,Cao X

更新日期：2015-09-01 00:00:00

abstract：:Ro52 is a common target of circulating autoantibodies in autoimmune disease. Data indicate that anti-Ro52 antibodies are associated with distinct clinical manifestations. It is therefore of major interest to understand how it becomes an antigenic target and what cells express this protein under what conditions and wha...

journal_title：Journal of autoimmunity

authors： Oke V,Wahren-Herlenius M

更新日期：2012-08-01 00:00:00

abstract：:Tight-skin (TSK) mouse, the experimental model for scleroderma, develops cutaneous hyperplasia, cardiac hypertrophy, pulmonary emphysema and autoimmunity against scleroderma target autoantigens. The cutaneous hyperplasia is associated with the accumulation of microfibrils and elastic fibers in the middle and deep derm...

journal_title：Journal of autoimmunity

authors： Kasturi KN,Hatakeyama A,Murai C,Gordon R,Phelps RG,Bona CA

更新日期：1997-12-01 00:00:00

abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

journal_title：Journal of autoimmunity

authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

更新日期：2009-08-01 00:00:00

abstract：:Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expre...

journal_title：Journal of autoimmunity

authors： Rattay K,Meyer HV,Herrmann C,Brors B,Kyewski B

更新日期：2016-02-01 00:00:00

abstract：:Catastrophic antiphospholipid (Asherson's) syndrome (cAPS) was described in the past as a severe variant of the antiphospholipid syndrome (APS). Currently growing evidence suggests it is a unique condition. This statement is based on several clinical and physiopathological features that although not well understood de...

journal_title：Journal of autoimmunity

authors： Ortega-Hernandez OD,Agmon-Levin N,Blank M,Asherson RA,Shoenfeld Y

更新日期：2009-02-01 00:00:00

abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

journal_title：Journal of autoimmunity

authors： Daikh DI,Wofsy D

更新日期：1999-03-01 00:00:00

abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

journal_title：Journal of autoimmunity

authors： Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

更新日期：2002-11-01 00:00:00

abstract：:Neuropsychiatric disease is one of the most common manifestations of human systemic lupus erythematosus, but the mechanisms remain poorly understood. In human brain microvascular endothelial cells in vitro, TNF-like weak inducer of apoptosis (TWEAK) decreases tight junction ZO-1 expression and increases the permeabili...

journal_title：Journal of autoimmunity

authors： Wen J,Doerner J,Weidenheim K,Xia Y,Stock A,Michaelson JS,Baruch K,Deczkowska A,Gulinello M,Schwartz M,Burkly LC,Putterman C

更新日期：2015-06-01 00:00:00

abstract：:Bullous pemphigoid (BP) and linear IgA disease (LAD) are autoimmune subepidermal blistering skin diseases associated with autoantibodies against the transmembrane hemidesmosomal protein BP180/type XVII collagen. It has been demonstrated previously that BP is characterized predominantly by IgG autoantibodies, while aut...

journal_title：Journal of autoimmunity

authors： Kromminga A,Scheckenbach C,Georgi M,Hagel C,Arndt R,Christophers E,Bröcker EB,Zillikens D

更新日期：2000-11-01 00:00:00

abstract：:The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at...

journal_title：Journal of autoimmunity

authors： Cihak J,Hoffmann-Fezer G,Wasl M,Merkle H,Kaspers B,Vainio O,Plachý J,Hála K,Wick G,Stangassinger M,Lösch U

更新日期：1998-04-01 00:00:00

abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

journal_title：Journal of autoimmunity

authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

更新日期：2001-12-01 00:00:00

abstract：:The Ro ribonucleoprotein particle (RoRNP) is the target of a variety of specific anti-protein autoantibodies produced by patients with systemic autoimmune diseases. RoRNPs, the function of which remains elusive, appear to be rather heterogeneous in terms of their molecular composition. Among several Ro proteins, a pro...

journal_title：Journal of autoimmunity

authors： Ricchiuti V,Pruijn GJ,Thijssen JP,van Venrooij WJ,Muller S

更新日期：1997-04-01 00:00:00

abstract：:Immunization with antigen-specific T cells has been used successfully in the treatment of several T cell-mediated experimental autoimmune diseases, including experimental allergic encephalomyelitis, thyroiditis, and adjuvant arthritis. The aim of this study was to determine whether T-cell vaccination could be used to ...

journal_title：Journal of autoimmunity

authors： Kahn CR,McIntosh KR,Drachman DB

更新日期：1990-12-01 00:00:00

abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

journal_title：Journal of autoimmunity

authors： Ge X,James EA,Reijonen H,Kwok WW

更新日期：2011-03-01 00:00:00

abstract：:Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved...

journal_title：Journal of autoimmunity

authors： Nesher G

更新日期：2014-02-01 00:00:00

abstract：:Psoriasis and Psoriatic Arthritis (PsA) are chronic inflammatory diseases that have a major impact on health. The prevalence and incidence estimates of these two closely related diseases show ethnic and geographic variations, being generally more common in the colder north than in the tropics. In Europe the prevalence...

journal_title：Journal of autoimmunity

authors： Chandran V,Raychaudhuri SP

更新日期：2010-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

journal_title：Journal of autoimmunity

authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

更新日期：2012-05-01 00:00:00