Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells.

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is implicated as a mediator of islet beta-cell destruction in autoimmune, insulin-dependent diabetes mellitus (IDDM). Because interleukin 12 (IL-12) is a potent inducer of IFN-gamma production, we sought evidence implicating IL-12 in IDDM development. In the present study, we used a revers...

journal_title：Journal of autoimmunity

authors： Rabinovitch A,Suarez-Pinzon WL,Sorensen O

更新日期：1996-10-01 00:00:00

abstract：:Peptidyl arginine deiminases (PADs) catalyze a post-translational protein modification reaction called citrullination, where arginine is converted to citrulline. This modification has been linked to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). More recently, several studies have suggest...

journal_title：Journal of autoimmunity

authors： Acharya NK,Nagele EP,Han M,Coretti NJ,DeMarshall C,Kosciuk MC,Boulos PA,Nagele RG

更新日期：2012-06-01 00:00:00

abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

journal_title：Journal of autoimmunity

authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

更新日期：1989-12-01 00:00:00

abstract：:B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

journal_title：Journal of autoimmunity

authors： Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

更新日期：2017-02-01 00:00:00

abstract：:Increasing evidence suggests that immune complexes made of anti-nuclear antibodies bound to nucleosomes released from dead cells play an important role in the pathogenesis of lupus nephritis. However, the nature and composition of apoptotic nucleosomes still remain elusive. Since large amounts of nucleosomes are relea...

journal_title：Journal of autoimmunity

authors： Cabrespines A,Laderach D,Lebossé C,Bach JF,Koutouzov S

更新日期：1998-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

journal_title：Journal of autoimmunity

authors： Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

更新日期：2000-02-01 00:00:00

abstract：:We compared the classical immunofluorescence test (IFT) and counterimmunoelectrophoresis method (CIE) with the new immunoblotting technique (IBT) for the detection of antinuclear antibodies (ANA). Sera from 200 patients were tested in all three assays. Patients were classified as having either rheumatic disease includ...

journal_title：Journal of autoimmunity

authors： Westgeest AA,van den Brink HG,de Jong J,Swaak AJ,Smeenk RJ

更新日期：1988-04-01 00:00:00

abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

journal_title：Journal of autoimmunity

authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:Sera from autoimmune patients and normal volunteers were tested for antibodies to the A1 core protein of heteronuclear ribonucleoprotein (hnRNP) particles by ELISA and Western blot assays. The A1 protein used in these studies was produced by recombinant DNA technology. Thirty-seven per cent of patients with systemic l...

journal_title：Journal of autoimmunity

authors： Jensen L,Kuff EL,Wilson SH,Steinberg AD,Klinman DM

更新日期：1988-02-01 00:00:00

abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

journal_title：Journal of autoimmunity

authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

更新日期：2012-06-01 00:00:00

abstract：:In a prospective study to evaluate the prevalence and predictive potential of circulating cytoplasmatic islet cell antibodies (ICA) and competitive insulin autoantibodies (CIAA), we screened 406 non-diabetic first-degree relatives of patients with Type I diabetes mellitus (n = 154 for CIAA). The prevalence of ICA was ...

journal_title：Journal of autoimmunity

authors： Ziegler AG,Baumgartl HJ,Standl E,Mehnert H

更新日期：1990-10-01 00:00:00

abstract：:University of California at Davis (UCD) lines 200 and 206 chickens develop a hereditary systemic scleroderma-like connective tissue disease characterized by severe lymphocytic infiltration and excessive accumulation of collagen in skin and internal organs. The immune system seems to play an important role in the devel...

journal_title：Journal of autoimmunity

authors： Sgonc R,Dietrich H,Gershwin ME,Colombatti A,Wick G

更新日期：1995-10-01 00:00:00

abstract：:The adrenocortical response is central to recovery from experimental allergic encephalomyelitis (EAE) in the Lewis rat, as reflected by the increased severity of the disease in adrenalectomized animals. The protection conferred by glucocorticoids is related to the immunosuppressive effects of the steroid, which may in...

journal_title：Journal of autoimmunity

authors： Smith T,Schmied M,Hewson AK,Lassmann H,Cuzner ML

更新日期：1996-04-01 00:00:00

abstract：:The Ro ribonucleoprotein particle (RoRNP) is the target of a variety of specific anti-protein autoantibodies produced by patients with systemic autoimmune diseases. RoRNPs, the function of which remains elusive, appear to be rather heterogeneous in terms of their molecular composition. Among several Ro proteins, a pro...

journal_title：Journal of autoimmunity

authors： Ricchiuti V,Pruijn GJ,Thijssen JP,van Venrooij WJ,Muller S

更新日期：1997-04-01 00:00:00

abstract：:Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

journal_title：Journal of autoimmunity

authors： Chiaroni-Clarke RC,Munro JE,Ellis JA

更新日期：2016-05-01 00:00:00

abstract：:The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the...

journal_title：Journal of autoimmunity

authors： Doria A,Gershwin ME,Selmi C

更新日期：2016-11-01 00:00:00

abstract：:Autoimmune diseases are characterized serologically by the presence of antibodies to specific autoantigens. Antibodies to the two antigens Ro/SSA and La/SSB are found in patients with primary (pSS) and secondary Sjögren's syndrome (sSS). To explore if differences in the fine specificity of these autoantibodies could b...

journal_title：Journal of autoimmunity

authors： Wahren M,Solomin L,Pettersson I,Isenberg D

更新日期：1996-08-01 00:00:00

abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

journal_title：Journal of autoimmunity

authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

journal_title：Journal of autoimmunity

authors： Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

更新日期：2013-03-01 00:00:00

abstract：:Solute carrier family 11 member a1 (SLC11A1) exerts pleiotropic effects on macrophage function. Expression of SLC11A1 is regulated by a (GT)(n) microsatellite promoter repeat polymorphism of which nine alleles have been described. Enhanced activation of macrophages, associated with increased expression from allele 3, ...

journal_title：Journal of autoimmunity

authors： O'Brien BA,Archer NS,Simpson AM,Torpy FR,Nassif NT

更新日期：2008-08-01 00:00:00

abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

journal_title：Journal of autoimmunity

authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

更新日期：2009-08-01 00:00:00

abstract：:The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

journal_title：Journal of autoimmunity

authors： Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

更新日期：1991-12-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by necrotizing vasculitis with the presence of pathogenic ANCA. ANCA can potentially cause neutrophil activation and induce neutrophil extracellular traps (NETs), resulting in endothelial damage as well as activation of autoreacti...

journal_title：Journal of autoimmunity

authors： Watanabe-Kusunoki K,Nakazawa D,Kusunoki Y,Kudo T,Hattanda F,Nishio S,Masuda S,Tomaru U,Kondo T,Atsumi T,Ishizu A

更新日期：2020-03-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell mediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4+ T-cells, whose adoptive transfer can also induce passive disease. In the Lewis rat EAE is a transient disease inducing lasting resistance to rechallenge. Th...

journal_title：Journal of autoimmunity

authors： Lohse AW,Schwerdt A,Herkel J,Spahn T,Meyer zum Büschenfelde KH

更新日期：1995-06-01 00:00:00

abstract：:Congenital immune deficiency states have often been valuable experimental models of nature that have significantly enhanced our understanding of the immune response. The relationship between CD4+, CD25+ and Treg cells in the induction of autoimmunity has attracted significant attention. We report herein a male child o...

journal_title：Journal of autoimmunity

authors： Aoki CA,Roifman CM,Lian ZX,Bowlus CL,Norman GL,Shoenfeld Y,Mackay IR,Gershwin ME

更新日期：2006-08-01 00:00:00

abstract：:The majority of patients with Dermatitis Herpetiformis (DH) have a gluten-sensitive enteropathy which may be triggered by a T cell-mediated immune response to gluten. Using a proliferative assay, the responses to gluten fraction III, recall antigens and mitogens of peripheral blood mononuclear cells (PBMC) and gut T c...

journal_title：Journal of autoimmunity

authors： Baker BS,Garioch JJ,Bokth S,Thomas H,Walker MM,Leonard JN,Fry L

更新日期：1995-08-01 00:00:00

abstract：:The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an infectious disease caused by SARS-CoV-2, which causes pneumonia, requires intensive care unit hospitalization in about 10% of cases and can lead to ...

journal_title：Journal of autoimmunity

authors： Perricone C,Triggianese P,Bartoloni E,Cafaro G,Bonifacio AF,Bursi R,Perricone R,Gerli R

更新日期：2020-07-01 00:00:00

abstract：:The features of autoantibodies (autoAb) to liver fumarylacetoacetate hydrolase (FAH) elicited in mice infected with mouse hepatitis virus (MHV) were studied by ELISA and western-blot competition assays. All sera tested contained Ab to cryptic FAH epitopes according with results from western-blot tests, whereas ELISA d...

journal_title：Journal of autoimmunity

authors： Mathieu PA,Gómez KA,Coutelier JP,Retegui LA

更新日期：2004-09-01 00:00:00