Abstract：
:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. Although the exact molecular mechanisms underlying the pathophysiological processes in SLE remain unknown, several inherent and environmental factors seem to be involved in the ethiopathogenesis of this disorder. Viruses may be one of the factors that induce the production of autoreactive antibodies although the involved mechanisms are still incompletely understood. One proposed mechanism for virus-induced production of autoantibodies is molecular mimicry. Another mechanism derives from studies with the human polyomavirus BK. In these studies, in vivo binding of the polyomaviruses large T-antigen to chromatin of infected cells may render chromatin immunogenic. The large T-antigen-chromatin complex may thus function as a hapten-carrier model with subsequent production of anti-chromatin antibodies, including anti-dsDNA and anti-histones antibodies. This review focuses on the recent findings suggesting that this model may be applicable for other human viruses associated with SLE.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Van Ghelue M,Moens U,Bendiksen S,Rekvig OPdoi
10.1016/s0896-8411(02)00110-5subject
Has Abstractpub_date
2003-03-01 00:00:00pages
171-82issue
2eissn
0896-8411issn
1095-9157pii
S0896841102001105journal_volume
20pub_type
杂志文章,评审abstract：:It has been recently suggested that primary Sjögren's syndrome (SS) patients present with a variety of personality structure disturbances and psychiatric symptoms. To evaluate this finding further, we assessed hostility structure and psychiatric symptoms in 33 Sjögren's syndrome patients and compared the results with ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(89)90180-7
更新日期：1989-08-01 00:00:00
abstract：:Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppress...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaut.2015.01.001
更新日期：2015-04-01 00:00:00
abstract：:Murine monoclonal antibodies (mAb) reacting with affinity-purified antihistone antibodies (AHA) from serum of a patient with systemic lupus erythematosus (SLE) were obtained. One of them, 8B3, was initially considered to recognize idiotypic (Id) determinants in AHA since (a) it reacted with AHA but not with control Ig...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(92)90149-k
更新日期：1992-06-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2014.11.001
更新日期：2015-01-01 00:00:00
abstract：:Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) o...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2003.09.006
更新日期：2004-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2013.12.007
更新日期：2014-08-01 00:00:00
abstract：:T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1995.0017
更新日期：1995-04-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2016.02.011
更新日期：2016-05-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2007.12.004
更新日期：2008-05-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1994.1069
更新日期：1994-12-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2005.01.003
更新日期：2005-03-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1996.0062
更新日期：1996-08-01 00:00:00
abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2005.05.007
更新日期：2005-09-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2012.03.004
更新日期：2012-06-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2016.07.008
更新日期：2016-12-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2012.09.002
更新日期：2012-12-01 00:00:00
abstract：:The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the...
journal_title：Journal of autoimmunity
pub_type： 社论,评审
doi：10.1016/j.jaut.2016.08.007
更新日期：2016-11-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2007.10.006
更新日期：2008-06-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2020.102591
更新日期：2021-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2010.07.007
更新日期：2010-12-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2017.05.004
更新日期：2017-09-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2009.10.003
更新日期：2010-06-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,多中心研究
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更新日期：2020-11-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/s0896-8411(03)00119-7
更新日期：2003-11-01 00:00:00
abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2010.06.006
更新日期：2010-11-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1994.1067
更新日期：1994-12-01 00:00:00
abstract：:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2011.10.003
更新日期：2012-05-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2007.12.002
更新日期：2008-05-01 00:00:00
