Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.

abstract：:Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

journal_title：Journal of autoimmunity

authors： Chiaroni-Clarke RC,Munro JE,Ellis JA

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Gut dysbiosis has been reported implicated in ankylosing spondylitis (AS), a common chronic inflammatory disease mainly affects sacroiliac joints and spine. Utilizing deep sequencing on the feces of untreated AS patients, our study aimed at providing an in-depth understanding of AS gut microbiota. METHODS:We...

journal_title：Journal of autoimmunity

authors： Zhou C,Zhao H,Xiao XY,Chen BD,Guo RJ,Wang Q,Chen H,Zhao LD,Zhang CC,Jiao YH,Ju YM,Yang HX,Fei YY,Wang L,Shen M,Li H,Wang XH,Lu X,Yang B,Liu JJ,Li J,Peng LY,Zheng WJ,Zhang CY,Zhou JX,Wu QJ,Yang YJ,Su

更新日期：2020-02-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

journal_title：Journal of autoimmunity

authors： Pearson JA,Wong FS,Wen L

更新日期：2016-01-01 00:00:00

abstract：:IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum...

journal_title：Journal of autoimmunity

authors： Bendaoud B,Pennec YL,Lelong A,Le Noac'h JF,Magadur G,Jouquan J,Youinou P

更新日期：1991-02-01 00:00:00

abstract：:(Beta2-glycoprotein I (beta2GPI) is a plasma protein that plays an important role in the antigenic specificity of antiphospholipid autoantibodies (aPL). These antibodies are associated with an increased risk for thrombosis and recurrent foetal loss in humans. Crystallographic analysis of beta2GPI showed that its five ...

journal_title：Journal of autoimmunity

authors： Iverson GM,Matsuura E,Victoria EJ,Cockerill KA,Linnik MD

更新日期：2002-06-01 00:00:00

abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

journal_title：Journal of autoimmunity

authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

更新日期：2002-12-01 00:00:00

abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

journal_title：Journal of autoimmunity

authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

更新日期：2001-12-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00

abstract：:Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient with PBC with the mouse human heterohybrid cell line F3B6. Previ...

journal_title：Journal of autoimmunity

authors： Leung PS,Krams S,Munoz S,Surh CP,Ansari A,Kenny T,Robbins DL,Fung J,Starzl TE,Maddrey W

更新日期：1992-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

journal_title：Journal of autoimmunity

authors： Qin K,Han C,Zhang H,Li T,Li N,Cao X

更新日期：2017-07-01 00:00:00

abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

journal_title：Journal of autoimmunity

authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

更新日期：1999-09-01 00:00:00

abstract：:The features of autoantibodies (autoAb) to liver fumarylacetoacetate hydrolase (FAH) elicited in mice infected with mouse hepatitis virus (MHV) were studied by ELISA and western-blot competition assays. All sera tested contained Ab to cryptic FAH epitopes according with results from western-blot tests, whereas ELISA d...

journal_title：Journal of autoimmunity

authors： Mathieu PA,Gómez KA,Coutelier JP,Retegui LA

更新日期：2004-09-01 00:00:00

abstract：:The development of autoimmune diseases is characterized by the breakdown of mechanism(s) that are responsible for maintaining immunological tolerance against self-structures in the periphery. Several aberrations of immune cells have been described so far. Most recently quantitative and/or qualitative defects of T cell...

journal_title：Journal of autoimmunity

authors： Scheinecker C,Bonelli M,Smolen JS

更新日期：2010-11-01 00:00:00

abstract：:Murine monoclonal antibodies (mAb) reacting with affinity-purified antihistone antibodies (AHA) from serum of a patient with systemic lupus erythematosus (SLE) were obtained. One of them, 8B3, was initially considered to recognize idiotypic (Id) determinants in AHA since (a) it reacted with AHA but not with control Ig...

journal_title：Journal of autoimmunity

authors： Subiza JL,Caturla A,Pereira LF,Camargo MC,Bustos A,Boimorto R,de la Concha EG

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...

journal_title：Journal of autoimmunity

authors： Zhang L,Li Y,Qiu W,Bell BA,Dvorina N,Baldwin WM 3rd,Singer N,Kern T,Caspi RR,Fox DA,Lin F

更新日期：2018-06-01 00:00:00

abstract：:Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, ...

journal_title：Journal of autoimmunity

authors： Chighizola CB,Pregnolato F,Andreoli L,Bodio C,Cesana L,Comerio C,Gerosa M,Grossi C,Kumar R,Lazzaroni MG,Mahler M,Mattia E,Nalli C,Norman GL,Raimondo MG,Ruffatti A,Tonello M,Trespidi L,Tincani A,Borghi MO,Meroni PL

更新日期：2018-06-01 00:00:00

abstract：:IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

journal_title：Journal of autoimmunity

authors： Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

更新日期：1996-06-01 00:00:00

abstract：:We have previously described an SLE-derived human hybridoma autoantibody, 9604, which binds to activated but not to resting platelets, inhibits platelet aggregation, and immunoprecipitates a surface-labelled poly-peptide of 32,000 molecular weight (MW) (p32). In the present study, using a murine monoclonal anti-p32 an...

journal_title：Journal of autoimmunity

authors： Xu H,Frojmovic MM,Wong T,Rauch J

更新日期：1995-02-01 00:00:00

abstract：:Peptidyl arginine deiminases (PADs) catalyze a post-translational protein modification reaction called citrullination, where arginine is converted to citrulline. This modification has been linked to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). More recently, several studies have suggest...

journal_title：Journal of autoimmunity

authors： Acharya NK,Nagele EP,Han M,Coretti NJ,DeMarshall C,Kosciuk MC,Boulos PA,Nagele RG

更新日期：2012-06-01 00:00:00

abstract：:Bullous pemphigoid (BP) and linear IgA disease (LAD) are autoimmune subepidermal blistering skin diseases associated with autoantibodies against the transmembrane hemidesmosomal protein BP180/type XVII collagen. It has been demonstrated previously that BP is characterized predominantly by IgG autoantibodies, while aut...

journal_title：Journal of autoimmunity

authors： Kromminga A,Scheckenbach C,Georgi M,Hagel C,Arndt R,Christophers E,Bröcker EB,Zillikens D

更新日期：2000-11-01 00:00:00

abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

journal_title：Journal of autoimmunity

authors： Simons PJ,Delemarre FG,Drexhage HA

更新日期：2000-12-01 00:00:00

abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

journal_title：Journal of autoimmunity

authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is implicated as a mediator of islet beta-cell destruction in autoimmune, insulin-dependent diabetes mellitus (IDDM). Because interleukin 12 (IL-12) is a potent inducer of IFN-gamma production, we sought evidence implicating IL-12 in IDDM development. In the present study, we used a revers...

journal_title：Journal of autoimmunity

authors： Rabinovitch A,Suarez-Pinzon WL,Sorensen O

更新日期：1996-10-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is associated with low serum immunoglobulin concentrations and an increased susceptibility to infections and autoimmune diseases. The treatment of choice for CVID patients is replacement intravenous immunoglobulin (IVIg) therapy. IVIg has been beneficial in preventing or allevia...

journal_title：Journal of autoimmunity

authors： Bayry J,Fournier EM,Maddur MS,Vani J,Wootla B,Sibéril S,Dimitrov JD,Lacroix-Desmazes S,Berdah M,Crabol Y,Oksenhendler E,Lévy Y,Mouthon L,Sautès-Fridman C,Hermine O,Kaveri SV

更新日期：2011-02-01 00:00:00

abstract：:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

journal_title：Journal of autoimmunity

authors： Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

更新日期：2017-01-01 00:00:00

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nerves evolving with diffuse sensory and motor symptoms. Although it is claimed that in neurodegenerative pathologies, a common feature is the failure of proteolytic systems to adequately eliminate aggregated or...

journal_title：Journal of autoimmunity

authors： Brun S,Schall N,Bonam SR,Bigaut K,Mensah-Nyagan AG,de Sèze J,Muller S

更新日期：2018-08-01 00:00:00

abstract：:Susceptibility to Pemphigus, an autoimmune disease of the skin, has been previously linked to DRB1*0402, 1401/04 and DQB1*0503 in pemphigus vulgaris (PV), to DRB1*0102, 0404, 1402/06 in endemic pemphigus foliaceus in Brazil and to DRB1*04 in Italian patients suffering from pemphigus foliaceus (PF). The disease is caus...

journal_title：Journal of autoimmunity

authors： Loiseau P,Lecleach L,Prost C,Lepage V,Busson M,Bastuji-Garin S,Roujeau JC,Charron D

更新日期：2000-08-01 00:00:00

abstract：:CD4(+) T cells specific for immunologic non-self determinants on self-IgG, idiotopes (Id), can be raised from cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS). To test if Id-specific CD4(+) T cells have the potential to destroy oligodendrocytes (ODCs), we analyzed their ability to induce ap...

journal_title：Journal of autoimmunity

authors： Hestvik AL,Skorstad G,Vartdal F,Holmøy T

更新日期：2009-03-01 00:00:00

abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

journal_title：Journal of autoimmunity

authors： Derksen RH,de Groot PG

更新日期：2000-09-01 00:00:00