Finding genes for SLE: complex interactions and complex populations.

abstract：:HLA-DQB1 is widely considered to be the major histocompatibility complex (MHC) susceptibility gene for type 1 diabetes (T1D). However, since inheritance of the gene in T1D is recessive, the presence of the protective HLA-DQB1 0602 allele with normal nucleotide sequence in some patients raises the question of whether H...

journal_title：Journal of autoimmunity

authors： Husain Z,Kelly MA,Eisenbarth GS,Pugliese A,Awdeh ZL,Larsen CE,Alper CA

更新日期：2008-06-01 00:00:00

abstract：:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addi...

journal_title：Journal of autoimmunity

authors： Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

更新日期：1992-08-01 00:00:00

abstract：:The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and...

journal_title：Journal of autoimmunity

authors： Xu C,Wu F,Mao C,Wang X,Zheng T,Bu L,Mou X,Zhou Y,Yuan G,Wang S,Xiao Y

更新日期：2016-12-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the secretion of autoantibodies. The mechanisms of autoantibody-induced disease have not been clarified. 1,25-Dihydroxy-vitamin D3 (1,25-D3) is known to be important in the regulation of normal human lymphocyte functions. Among...

journal_title：Journal of autoimmunity

authors： Chong PJ,Matzner WL,Wallace DJ,Klinenberg JR,Toyoda M,Jordan SC

更新日期：1989-12-01 00:00:00

abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

journal_title：Journal of autoimmunity

authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

更新日期：2020-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

journal_title：Journal of autoimmunity

authors： Fava A,Petri M

更新日期：2019-01-01 00:00:00

abstract：:The murine model of human insulin dependent diabetes mellitus (IDDM), the non-obese diabetic (NOD) mouse, develops a T cell-dependent destruction of pancreatic islets. While the target antigens are unknown, there is clearly a lack of tolerance to them. Neonatal intrathymic (i.t.) antigen injection has been successfull...

journal_title：Journal of autoimmunity

authors： Charlton B,Taylor-Edwards C,Tisch R,Fathman CG

更新日期：1994-10-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our wo...

journal_title：Journal of autoimmunity

authors： Dieudonné Y,Gies V,Guffroy A,Keime C,Bird AK,Liesveld J,Barnas JL,Poindron V,Douiri N,Soulas-Sprauel P,Martin T,Meffre E,Anolik JH,Korganow AS

更新日期：2019-08-01 00:00:00

abstract：:There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

journal_title：Journal of autoimmunity

authors： Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

更新日期：1992-04-01 00:00:00

abstract：:Physiologically, HLA Class II molecules are primarily expressed on immunoregulatory cells. In recent years, it has been shown that tissues affected by autoimmunity, including beta cells of 'diabetic' pancreases, 'inappropriately' express these glycoproteins. Cytokines are potent Class II inducers on a variety of cells...

journal_title：Journal of autoimmunity

authors： Pujol-Borrell R,Soldevila G,Buscema M,Vives M,Badenas J,Marakian R,Bottazzo GF

更新日期：1989-06-01 00:00:00

abstract：:New Zealand (NZ) mouse strains comprise both autoimmune and non-autoimmune animals: NZ black (NZB) mice and the F1 hybrid (NZB/W) of NZB and NZ white (NZW) mice show spontaneous autoimmune disease by 6 months of age and die before the first year of age from renal disease, while NZW mice do not show autoimmune disorder...

journal_title：Journal of autoimmunity

authors： Esaguy N,Macedo PM,Castro AP,Aguas AP

更新日期：1992-10-01 00:00:00

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:The clinical manifestations of graft rejection or autoimmune disease represent the terminal phase in a complex sequence of inflammatory events. Although the spectrum of response to injury within each tissue is normally narrowly defined, the immune mechanisms involved may be heterogeneous, influenced by the immune stat...

journal_title：Journal of autoimmunity

authors： Keown PA

更新日期：1992-04-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:University of California at Davis (UCD) lines 200 and 206 chickens develop a hereditary systemic scleroderma-like connective tissue disease characterized by severe lymphocytic infiltration and excessive accumulation of collagen in skin and internal organs. The immune system seems to play an important role in the devel...

journal_title：Journal of autoimmunity

authors： Sgonc R,Dietrich H,Gershwin ME,Colombatti A,Wick G

更新日期：1995-10-01 00:00:00

abstract：:In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

journal_title：Journal of autoimmunity

authors： Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

更新日期：2000-03-01 00:00:00

abstract：:The great majority of insulin-specific T cell clones isolated from islets of NOD mice react with insulin peptide B-(9-23) (amino acids 9-23 of the insulin B chain). The T cell receptors of these clones contain diverse beta-chains but restricted alpha-chains. The dominant alpha-chain motif is a V alpha 13 segment (10 o...

journal_title：Journal of autoimmunity

authors： Simone EA,Yu L,Wegmann DR,Eisenbarth GS

更新日期：1997-06-01 00:00:00

abstract：:To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibi...

journal_title：Journal of autoimmunity

authors： Vento S,McFarlane BM,Vento TG,Ranieri S,Rondanelli EG,McFarlane IG,Williams R,Eddleston AL

更新日期：1988-06-01 00:00:00

abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

journal_title：Journal of autoimmunity

authors： Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

更新日期：1989-06-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoim...

journal_title：Journal of autoimmunity

authors： Othy S,Bruneval P,Topçu S,Dugail I,Delers F,Lacroix-Desmazes S,Bayry J,Kaveri SV

更新日期：2012-09-01 00:00:00

abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

journal_title：Journal of autoimmunity

authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

更新日期：2001-12-01 00:00:00

abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

journal_title：Journal of autoimmunity

authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

更新日期：1989-12-01 00:00:00

abstract：:Since its description in 1965, Sneddon syndrome (SNS) is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The presence of many other manifestations suggests that it is a systemic syndrome. The prevalence of anti-phospholipid antibodies (aPL) is highly...

journal_title：Journal of autoimmunity

authors： Francès C,Piette JC

更新日期：2000-09-01 00:00:00

abstract：:The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

journal_title：Journal of autoimmunity

authors： Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

更新日期：1998-08-01 00:00:00

abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

journal_title：Journal of autoimmunity

authors： Ge X,James EA,Reijonen H,Kwok WW

更新日期：2011-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by necrotizing vasculitis with the presence of pathogenic ANCA. ANCA can potentially cause neutrophil activation and induce neutrophil extracellular traps (NETs), resulting in endothelial damage as well as activation of autoreacti...

journal_title：Journal of autoimmunity

authors： Watanabe-Kusunoki K,Nakazawa D,Kusunoki Y,Kudo T,Hattanda F,Nishio S,Masuda S,Tomaru U,Kondo T,Atsumi T,Ishizu A

更新日期：2020-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contri...

journal_title：Journal of autoimmunity

authors： François A,Gombault A,Villeret B,Alsaleh G,Fanny M,Gasse P,Adam SM,Crestani B,Sibilia J,Schneider P,Bahram S,Quesniaux V,Ryffel B,Wachsmann D,Gottenberg JE,Couillin I

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...

journal_title：Journal of autoimmunity

authors： Zhang L,Li Y,Qiu W,Bell BA,Dvorina N,Baldwin WM 3rd,Singer N,Kern T,Caspi RR,Fox DA,Lin F

更新日期：2018-06-01 00:00:00