Abstract:
:The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and we determined the effects of excessive iodine on the autophagy and apoptosis of thyroid follicular cells (TFCs) in an attempt to elucidate the effects of excess iodine on HT development. Our results showed decreases in the autophagy-related protein LC3B-II, and increases in caspase-3 were observed in thyroid tissues from HT patients. Interestingly, the suppression of autophagy activity in TFCs was induced by excess iodine in vitro, and this process is mediated through transforming growth factor-β1 downregulation and activation of the Akt/mTOR signaling pathway. In addition, excess iodine induced autophagy suppression and enhanced reactive oxygen species (ROS) production and apoptosis of TFCs, which could be rescued by the activation of autophagy. Taken together, our results demonstrated that excess iodine contributed to autophagy suppression and apoptosis of TFCs, which could be important factors predisposing to increased risk of HT development.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Xu C,Wu F,Mao C,Wang X,Zheng T,Bu L,Mou X,Zhou Y,Yuan G,Wang S,Xiao Ydoi
10.1016/j.jaut.2016.07.008subject
Has Abstractpub_date
2016-12-01 00:00:00pages
50-57eissn
0896-8411issn
1095-9157pii
S0896-8411(16)30116-0journal_volume
75pub_type
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