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Inappropriate expression of HLA class II molecules in endocrine epithelial cells: the phenomenon, the new experimental data and comparison with animal models.

Abstract：

:Physiologically, HLA Class II molecules are primarily expressed on immunoregulatory cells. In recent years, it has been shown that tissues affected by autoimmunity, including beta cells of 'diabetic' pancreases, 'inappropriately' express these glycoproteins. Cytokines are potent Class II inducers on a variety of cells but they exert a heterogenous effect when incubated with different human endocrine cells, i.e. thyroid cells are readily inducible, beta cells are much more resistant. The fine modulation of Class II expression by cytokines has been extensively studied and recent information on their action on endocrine cells is reported here. The possibility that distinct environmental factors from those postulated until now may be responsible for triggering the inappropriate expression of MHC molecules in epithelial cells in vivo is also emphasized. Despite several similarities between human Type I diabetes and spontaneous animal models of the disease, major differences still exist. Transgenic models have now been produced. However, even if they offer interesting new insights, they have not so far provided the decisive answer to explain the pathogenesis of human autoimmune diseases.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Pujol-Borrell R,Soldevila G,Buscema M,Vives M,Badenas J,Marakian R,Bottazzo GF

doi

10.1016/0896-8411(89)90127-3

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

163-9

eissn

0896-8411

issn

1095-9157

journal_volume

2 Suppl

pub_type

杂志文章,评审

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