Cyclosporin monitoring: its role in autoimmune indications.

abstract：:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against th...

journal_title：Journal of autoimmunity

authors： Mobini R,Staudt A,Felix SB,Baumann G,Wallukat G,Deinum J,Svensson H,Hjalmarson A,Fu M

更新日期：2003-06-01 00:00:00

abstract：:Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

journal_title：Journal of autoimmunity

authors： Gleicher N,Barad DH

更新日期：2007-02-01 00:00:00

abstract：:Immunostimulatory CpG motifs can preferentially induce Th1 immune responses and have been applied to treat Th2-dominant disease. In this study, we investigated whether a plasmid with the addition of 20 copies of an immunostimulatory CpG motif (pB-CpG20) might prevent the development of scleroderma-like syndrome in tig...

journal_title：Journal of autoimmunity

authors： Shen Y,Ichino M,Nakazawa M,Ikejima T,Kojima Y,Okuda K,Minami M

更新日期：2005-05-01 00:00:00

abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

journal_title：Journal of autoimmunity

authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

更新日期：2014-05-01 00:00:00

abstract：:The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and...

journal_title：Journal of autoimmunity

authors： Xu C,Wu F,Mao C,Wang X,Zheng T,Bu L,Mou X,Zhou Y,Yuan G,Wang S,Xiao Y

更新日期：2016-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the secretion of autoantibodies. The mechanisms of autoantibody-induced disease have not been clarified. 1,25-Dihydroxy-vitamin D3 (1,25-D3) is known to be important in the regulation of normal human lymphocyte functions. Among...

journal_title：Journal of autoimmunity

authors： Chong PJ,Matzner WL,Wallace DJ,Klinenberg JR,Toyoda M,Jordan SC

更新日期：1989-12-01 00:00:00

abstract：:Malathion administration at non-cholinergical doses was shown to elevate macrophage, proliferative and humoral immune responses. This study examined the effects of malathion on autoimmunity, autoantibody formation, macrophage function and mitogenic responses in MRL-lpr mice (genetically predisposed to autoimmune disea...

journal_title：Journal of autoimmunity

authors： Rodgers KE

更新日期：1997-08-01 00:00:00

abstract：:The present study was undertaken to determine whether germline encoded and polyreactive antibodies might be pathogenic and whether the breach of early tolerance checkpoints in systemic lupus erythematosus (SLE) might lead to a population of B cells expressing germline encoded antibodies that become pathogenic merely b...

journal_title：Journal of autoimmunity

authors： Zhang J,Jacobi AM,Wang T,Berlin R,Volpe BT,Diamond B

更新日期：2009-11-01 00:00:00

abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

journal_title：Journal of autoimmunity

authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

更新日期：2020-03-01 00:00:00

abstract：:There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway. ...

journal_title：Journal of autoimmunity

authors： Michaelson JS,Wisniacki N,Burkly LC,Putterman C

更新日期：2012-09-01 00:00:00

abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

journal_title：Journal of autoimmunity

authors： Derksen RH,de Groot PG

更新日期：2000-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

journal_title：Journal of autoimmunity

authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

更新日期：2012-05-01 00:00:00

abstract：:Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our wo...

journal_title：Journal of autoimmunity

authors： Dieudonné Y,Gies V,Guffroy A,Keime C,Bird AK,Liesveld J,Barnas JL,Poindron V,Douiri N,Soulas-Sprauel P,Martin T,Meffre E,Anolik JH,Korganow AS

更新日期：2019-08-01 00:00:00

abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

journal_title：Journal of autoimmunity

authors： Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

更新日期：2002-11-01 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00

abstract：:Wegener's autoantigen (WA), a 29 kD multifunctional protein, is the principal target antigen of autoantibodies associated with Wegener's granulomatosis (WG). WA was first identified as proteinase 3 (PR3), which is now known to be identical with myeloblastin and AGP7. Like other lysosomal proteins, WA/PR3 displays enzy...

journal_title：Journal of autoimmunity

authors： Gross WL,Csernok E,Flesch BK

更新日期：1993-04-01 00:00:00

abstract：:The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

journal_title：Journal of autoimmunity

authors： Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

更新日期：1994-04-01 00:00:00

abstract：:Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprote...

journal_title：Journal of autoimmunity

authors： de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P

更新日期：2000-09-01 00:00:00

abstract：:Autoantibodies to adrenal medulla that gave a diffuse immunofluorescent staining pattern were detected in 17 out of 107 (16%) patients with newly diagnosed Type I diabetes mellitus, in 13 out of 178 (7%) patients with long lasting disease but in none of 80 mixed control sera tested. The antibodies were of IgG class an...

journal_title：Journal of autoimmunity

authors： Scherbaum WA,Mogel H,Boehm BO,Hedderich U,Glück M,Schernthaner G,Bottazzo GF,Pfeiffer EF

更新日期：1988-06-01 00:00:00

abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

journal_title：Journal of autoimmunity

authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

更新日期：2004-06-01 00:00:00

abstract：:Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

journal_title：Journal of autoimmunity

authors： Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

更新日期：2007-06-01 00:00:00

abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

journal_title：Journal of autoimmunity

authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

更新日期：2014-05-01 00:00:00

abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

journal_title：Journal of autoimmunity

authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

更新日期：2012-06-01 00:00:00

abstract：:The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

journal_title：Journal of autoimmunity

authors： Qin K,Han C,Zhang H,Li T,Li N,Cao X

更新日期：2017-07-01 00:00:00

abstract：:Most of our current understanding of the genetic predisposition to autoimmune disease can be traced to experiments performed in the decade from 1971 to 1981. Chella David was a key contributor to this research. Many of these early steps came from studies of experimental autoimmune thyroiditis. This model has been espe...

journal_title：Journal of autoimmunity

authors： Rose NR

更新日期：2011-09-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00

abstract：:The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) expression profiles were analysed in tissues with differing disease st...

journal_title：Journal of autoimmunity

authors： Clanchy FIL,Borghese F,Bystrom J,Balog A,Penn H,Hull DN,Wells GMA,Kiriakidis S,Taylor PC,Sacre SM,Williams LM,Stone TW,Mageed RA,Williams RO

更新日期：2021-01-22 00:00:00

abstract：:We have studied the cellular expression and functional conservation of the human La autoantigen across species by introducing genes encoding human La antigen into cultured murine cell lines. In transfected murine fibroblasts and lymphoid cell lines human La was expressed as a predominantly nuclear antigen, with a typi...

journal_title：Journal of autoimmunity

authors： Keech CL,Gordon TP,Reynolds P,McCluskey J

更新日期：1993-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown aetiology. Although it has been reported that T cells might be responsible for the pathogenesis of SLE, it remains unclear whether immune aberrations of SLE T cells are the primary event in this pathological process. We have recently report...

journal_title：Journal of autoimmunity

authors： Tsuzaka K,Takeuchi T,Onoda N,Pang M,Abe T

更新日期：1998-10-01 00:00:00