当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

Abstract：

:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the specificity of polyclonal Tregs through autoreactive TCR gene transfer technology. In this study, we examined whether Tregs engineered through retroviral transduction to express a TCR cross-reactive to two CNS autoantigens, myelin oligodendrocyte glycoprotein (MOG) and neurofilament-medium (NF-M), had a superior protective efficacy compared with Tregs expressing a MOG mono-specific TCR. We observed that engineered Tregs (engTregs) exhibited in vitro regulatory effects related to the antigenic specificity of the introduced TCR, and commensurate in potency with the avidity of the transduced TCR. In experimental autoimmune encephalomyelitis (EAE), adoptively transferred engTregs proliferated, and migrated to the CNS, while retaining FoxP3 expression. EngTregs expressing MOG/NF-M cross-reactive TCR had superior protective properties over engTregs expressing MOG-specific TCR in MOG-induced EAE. Remarkably, MOG/NF-M bi-specific TCR-engTregs also improved recovery from EAE induced by an unrelated CNS autoantigen, proteolipid protein (PLP). This study underlines the benefit of using TCRs cross-reacting towards multiple autoantigens, compared with mono-reactive TCR, for the generation of engTregs affording protection from autoimmune disease in adoptive cell therapy.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

doi

10.1016/j.jaut.2020.102401

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

102401

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(19)30833-9

journal_volume

108

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures.

    abstract：:Peripheral T cells can be polarized towards type 1 or type 2 cytokine immune responses during TCR engagement. Because T cell selection by peptide plus self-MHC in the thymus requires TCR engagement, we hypothesized that type 1 cytokines may polarize developing T cells. We cultured thymi from BBDR rats in adult thymus ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(02)00091-4

    authors： Whalen BJ,Marounek J,Mordes JP,Rossini AA,Greiner DL

    更新日期：2003-02-01 00:00:00

  • Isolation and characterization of two human monoclonal anti-phospholipid IgG from patients with autoimmune disease.

    abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0316

    authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

    更新日期：1999-09-01 00:00:00

  • Sjögren's syndrome at the crossroad of polyautoimmunity.

    abstract：:The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.05.008

    authors： Amador-Patarroyo MJ,Arbelaez JG,Mantilla RD,Rodriguez-Rodriguez A,Cárdenas-Roldán J,Pineda-Tamayo R,Guarin MR,Kleine LL,Rojas-Villarraga A,Anaya JM

    更新日期：2012-09-01 00:00:00

  • Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism.

    abstract：OBJECTIVE:We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). METHODS:From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.05.003

    authors： de Faire U,Su J,Hua X,Frostegård A,Halldin M,Hellenius ML,Wikström M,Dahlbom I,Grönlund H,Frostegård J

    更新日期：2010-03-01 00:00:00

  • Autoantibodies to adrenal medullary and thyroid calcitonin cells in type I diabetes mellitus--a prospective study.

    abstract：:Autoantibodies to adrenal medulla that gave a diffuse immunofluorescent staining pattern were detected in 17 out of 107 (16%) patients with newly diagnosed Type I diabetes mellitus, in 13 out of 178 (7%) patients with long lasting disease but in none of 80 mixed control sera tested. The antibodies were of IgG class an...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(88)90028-5

    authors： Scherbaum WA,Mogel H,Boehm BO,Hedderich U,Glück M,Schernthaner G,Bottazzo GF,Pfeiffer EF

    更新日期：1988-06-01 00:00:00

  • N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia.

    abstract：:We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotoc...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.03.003

    authors： Khan NA,Yessoufou A,Kim M,Hichami A

    更新日期：2006-06-01 00:00:00

  • Cell adhesion molecules: a selective therapeutic target for alleviation of IDDM.

    abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1069

    authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

    更新日期：1994-12-01 00:00:00

  • Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus.

    abstract：:Following the mass vaccinations against pandemic influenza A/H1N1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic neurological disorder characterized by excessive daytime ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2015.07.006

    authors： Saariaho AH,Vuorela A,Freitag TL,Pizza F,Plazzi G,Partinen M,Vaarala O,Meri S

    更新日期：2015-09-01 00:00:00

  • Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice.

    abstract：:Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS has both, a genetic and an environmental predisposition. Among all the genetic factors associated with MS susceptibility, HLA class II haplotypes such as DR2/DQ6, DR3/DQ2, and DR4/DQ8 show the strongest association. Although a direct ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2011.05.001

    authors： Luckey D,Bastakoty D,Mangalam AK

    更新日期：2011-09-01 00:00:00

  • Fine mapping of diabetes-associated IA-2 specific autoantibodies.

    abstract：:The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2003.08.002

    authors： Bearzatto M,Lampasona V,Belloni C,Bonifacio E

    更新日期：2003-12-01 00:00:00

  • New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

    abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2017.08.001

    authors： Harbige J,Eichmann M,Peakman M

    更新日期：2017-11-01 00:00:00

  • NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.

    abstract：:The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2017.04.006

    authors： Qin K,Han C,Zhang H,Li T,Li N,Cao X

    更新日期：2017-07-01 00:00:00

  • Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

    abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2018.08.009

    authors： Bonam SR,Wang F,Muller S

    更新日期：2018-11-01 00:00:00

  • The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families.

    abstract：:Several polymorphisms of the insulin gene and its flanking regions (INS region) are in linkage disequilibrium and confer susceptibility to insulin-dependent diabetes (IDDM). We have analysed INS AA and AB-BB genotypes at the 1,428 FokI site (3' of the insulin gene) in 217 patients with IDDM, 402 non-diabetic first deg...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1053

    authors： Pugliese A,Awdeh ZL,Alper CA,Jackson RA,Eisenbarth GS

    更新日期：1994-10-01 00:00:00

  • Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models.

    abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.09.005

    authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

    更新日期：2006-11-01 00:00:00

  • Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.

    abstract：:Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaut.2019.04.005

    authors： Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

    更新日期：2019-07-01 00:00:00

  • Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review.

    abstract：:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered,...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.09.002

    authors： Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

    更新日期：2012-12-01 00:00:00

  • Arthritis transferred by cells derived from pre-inflammatory rat synovium.

    abstract：:Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas periphera...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：

    authors： Ramos-Ruiz R,Bernabeu C,Ariza A,Fernández JM,Larraga V,López-Bote JP

    更新日期：1992-02-01 00:00:00

  • A functional and phenotypic study on immune accessory cells isolated from the thyroids of Wistar and autoimmune-prone BB-DP rats.

    abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2000.0438

    authors： Simons PJ,Delemarre FG,Drexhage HA

    更新日期：2000-12-01 00:00:00

  • Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.

    abstract：:Glutamic acid decarboxylase 65 (GAD65) is a putative autoantigen associated with the pathogenesis of type 1 diabetes (T1D). The prevalence of autoreactive CD4+ T cells towards the immunodominant GAD65(555-567) epitope in DR4 healthy and T1D subjects was investigated with class II tetramers. A slightly higher percentag...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2005.08.007

    authors： Danke NA,Yang J,Greenbaum C,Kwok WW

    更新日期：2005-12-01 00:00:00

  • Salivary gland epithelial cells (SGEC): carriers of exquisite B7-2 (CD86) costimulatory molecules.

    abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.06.006

    authors： Kapsogeorgou EK,Manoussakis MN

    更新日期：2010-11-01 00:00:00

  • Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study.

    abstract：:Primary biliary cirrhosis (PBC) sera contain antibodies which recognize various nuclear envelope proteins of which antibody against gp210 has been proven to be diagnostic for disease. In contrast, the clinical significance of another nuclear envelope antibody, anti-p62 antibody has not been well investigated. In the p...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0896-8411(03)00033-7

    authors： Miyachi K,Hankins RW,Matsushima H,Kikuchi F,Inomata T,Horigome T,Shibata M,Onozuka Y,Ueno Y,Hashimoto E,Hayashi N,Shibuya A,Amaki S,Miyakawa H

    更新日期：2003-05-01 00:00:00

  • Intracellular localization of histidyl-tRNA synthetase/Jo-1 antigen in T24 cells and some other cells.

    abstract：:Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.01.004

    authors： Kamei H

    更新日期：2004-05-01 00:00:00

  • T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients.

    abstract：:Myasthenia gravis (MG) is a prototypical antibody-mediated disease characterized by muscle weakness and fatigability. Serum antibodies to the acetylcholine receptor and muscle-specific tyrosine kinase receptor (MuSK) are found in about 85% and 8% of patients respectively. We have previously shown that more than 70% of...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.12.007

    authors： Marino M,Maiuri MT,Di Sante G,Scuderi F,La Carpia F,Trakas N,Provenzano C,Zisimopoulou P,Ria F,Tzartos SJ,Evoli A,Bartoccioni E

    更新日期：2014-08-01 00:00:00

  • cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.

    abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.03.001

    authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

    更新日期：2019-06-01 00:00:00

  • Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.

    abstract：:Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2014.01.002

    authors： Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

    更新日期：2014-05-01 00:00:00

  • Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells.

    abstract：:The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1017

    authors： Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

    更新日期：1994-04-01 00:00:00

  • Administering glutamic acid decarboxylase to NOD mice prevents diabetes.

    abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1067

    authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

    更新日期：1994-12-01 00:00:00

  • Juvenile autoimmune hepatitis: A comprehensive review.

    abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2018.10.007

    authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

    更新日期：2018-12-01 00:00:00

  • A role for MHC class II antigens in B-cell activation.

    abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90133-9

    authors： Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

    更新日期：1989-06-01 00:00:00