Structure-function studies on beta 2-glycoprotein I.

Abstract:

:Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprotein I. In this review we will discuss what the three-dimensional structure teaches us about the role of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P

doi

10.1006/jaut.2000.0394

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

87-9

issue

2

eissn

0896-8411

issn

1095-9157

pii

S0896841100903949

journal_volume

15

pub_type

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