Structure-function studies on beta 2-glycoprotein I.


:Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprotein I. In this review we will discuss what the three-dimensional structure teaches us about the role of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.


J Autoimmun


Journal of autoimmunity


de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P




Has Abstract


2000-09-01 00:00:00














  • Association of SLC11A1 promoter polymorphisms with the incidence of autoimmune and inflammatory diseases: a meta-analysis.

    abstract::Solute carrier family 11 member a1 (SLC11A1) exerts pleiotropic effects on macrophage function. Expression of SLC11A1 is regulated by a (GT)(n) microsatellite promoter repeat polymorphism of which nine alleles have been described. Enhanced activation of macrophages, associated with increased expression from allele 3, ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,meta分析


    authors: O'Brien BA,Archer NS,Simpson AM,Torpy FR,Nassif NT

    更新日期:2008-08-01 00:00:00

  • Autostimulatory factor produced by B-cell lines from patients with Sjögren's syndrome.

    abstract::Sjögren's syndrome (SS) is an autoimmune disease with a predisposition to transform into a B-cell lymphoma. Stable B-cell lines were established (without exogenous stimulation other than fetal bovine serum) from the peripheral blood of three SS patients. These cell lines secreted immunoglobulin (either IgG, IgM or bot...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Takei M,Dang H,Dauphinée MJ,Talal N

    更新日期:1989-08-01 00:00:00

  • Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies.

    abstract::Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly understood preclinical stage of immune dysregulation and symptom accrual. Accumulation of antinuclear autoantibody (ANA) specificities is a hallmark of impending clinical disease. Yet, many ANA-positive individuals remain healthy, suggest...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Lu R,Munroe ME,Guthridge JM,Bean KM,Fife DA,Chen H,Slight-Webb SR,Keith MP,Harley JB,James JA

    更新日期:2016-11-01 00:00:00

  • Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.

    abstract::HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by whi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Behrens M,Trejo T,Luthra H,Griffiths M,David CS,Taneja V

    更新日期:2010-08-01 00:00:00

  • Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis.

    abstract::The adrenocortical response is central to recovery from experimental allergic encephalomyelitis (EAE) in the Lewis rat, as reflected by the increased severity of the disease in adrenalectomized animals. The protection conferred by glucocorticoids is related to the immunosuppressive effects of the steroid, which may in...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Smith T,Schmied M,Hewson AK,Lassmann H,Cuzner ML

    更新日期:1996-04-01 00:00:00

  • The top ten clues to understand the origin of chronic lymphocytic leukemia (CLL).

    abstract::The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: García-Muñoz R,Feliu J,Llorente L

    更新日期:2015-01-01 00:00:00

  • Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells.

    abstract::Eight patients with arthritis (seven with rheumatoid, one with psoriatic arthritis) were treated for 7 d with a daily injection of 10 mg of mouse monoclonal anti-CD4 antibodies (three with VIT4, five with MT151). With the exception of a short-lasting low-grade fever in one patient, no side effects were observed. Clini...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Herzog C,Walker C,Müller W,Rieber P,Reiter C,Riethmüller G,Wassmer P,Stockinger H,Madic O,Pichler WJ

    更新日期:1989-10-01 00:00:00

  • Do naturally occurring autoantibodies participate in the constitution of the pathological B-cell repertoire in systemic lupus erythematosus?

    abstract::Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune diseases. In both human and mouse SLE diseases, the autoimmune response targets a restricted set of autoantigens. Many of them are nucleic acids and proteins involved in the synthesis and processing of DNA or RNA, a characteristic which should ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Gilbert D,Brard F,Jovelin F,Tron F

    更新日期:1996-04-01 00:00:00

  • T-cell vaccination in experimental myasthenia gravis: a double-edged sword.

    abstract::Immunization with antigen-specific T cells has been used successfully in the treatment of several T cell-mediated experimental autoimmune diseases, including experimental allergic encephalomyelitis, thyroiditis, and adjuvant arthritis. The aim of this study was to determine whether T-cell vaccination could be used to ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Kahn CR,McIntosh KR,Drachman DB

    更新日期:1990-12-01 00:00:00

  • Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

    abstract::Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

    更新日期:2015-02-01 00:00:00

  • TNF-alpha mediated modulation of T cell development and exacerbation of in vitro T1DM in fetal thymus organ culture.

    abstract::TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha early in life experience an acceleration in disease onset while TNF-alpha administered to adult NOD mice are ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Middlebrook AJ,Lebsack T,DeLuca D

    更新日期:2007-09-01 00:00:00

  • Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation?

    abstract::The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Derksen RH,de Groot PG

    更新日期:2000-09-01 00:00:00

  • N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia.

    abstract::We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotoc...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Khan NA,Yessoufou A,Kim M,Hichami A

    更新日期:2006-06-01 00:00:00

  • Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies.

    abstract::Common variable immunodeficiency (CVID) is associated with low serum immunoglobulin concentrations and an increased susceptibility to infections and autoimmune diseases. The treatment of choice for CVID patients is replacement intravenous immunoglobulin (IVIg) therapy. IVIg has been beneficial in preventing or allevia...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Bayry J,Fournier EM,Maddur MS,Vani J,Wootla B,Sibéril S,Dimitrov JD,Lacroix-Desmazes S,Berdah M,Crabol Y,Oksenhendler E,Lévy Y,Mouthon L,Sautès-Fridman C,Hermine O,Kaveri SV

    更新日期:2011-02-01 00:00:00

  • IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.

    abstract::IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Bendaoud B,Pennec YL,Lelong A,Le Noac'h JF,Magadur G,Jouquan J,Youinou P

    更新日期:1991-02-01 00:00:00

  • Elimination of infectious antigens and increase of IgG catabolism as possible modes of action of IVIg.

    abstract::Many mechanisms can explain the mode of action of IVIg in immune disorders. Macrophage blockade and interference in the idiotypic network are supported by some experimental data. Among the other mechanisms, two are considered in greater detail. Firstly, in some disorders, the patients could improve simply because the ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Masson PL

    更新日期:1993-12-01 00:00:00

  • Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1.

    abstract::Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

    更新日期:2001-09-01 00:00:00

  • The role of NK cell activity in the pathogenesis of poly I:C accelerated and spontaneous diabetes in the diabetes prone BB rat.

    abstract::The development of insulin dependent diabetes mellitus (IDDM) and diabetes in the diabetes prone (DP) BB rat animal model of IDDM is thought to be due to an autoimmune process. Natural killer (NK) cells have been implicated but not proven to play a pathogenetic role in BB rats due to the increased NK cell number and a...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Sobel DO,Azumi N,Creswell K,Holterman D,Blair OC,Bellanti JA,Abbassi V,Hiserodt JC

    更新日期:1995-12-01 00:00:00

  • Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritis.

    abstract::We have previously demonstrated, in the collagen-induced arthritis model (CIA), that repetitive injections of immature bone-marrow-derived dendritic cells (iDCs) induce the expansion of a population of CD4CD49b-expressing cells, and that their adoptive transfer results in protection against CIA in a prophylactic setti...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Charbonnier LM,Han WG,Quentin J,Huizinga TW,Zwerina J,Toes RE,Jorgensen C,Louis-Plence P

    更新日期:2010-06-01 00:00:00

  • Autoantibodies from Sjögren's syndrome induce activation of both the intrinsic and extrinsic apoptotic pathways in human salivary gland cell line A-253.

    abstract::Sjögren's syndrome (SS) is an autoimmune rheumatic disease that targets salivary and lachrymal glands, characterized by a high concentration of serum autoantibodies directed against nuclear and cytoplasmic antigens. It is known that autoantibodies can enter viable cells and this phenomenon has functional consequences ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Sisto M,Lisi S,Castellana D,Scagliusi P,D'Amore M,Caprio S,Scagliusi A,Acquafredda A,Panaro MA,Mitolo V

    更新日期:2006-08-01 00:00:00

  • The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development.

    abstract::Autoimmune hepatitis (AIH) is defined as a chronic liver inflammation with loss of tolerance against hepatocytes. The etiology and pathophysiology of AIH are still poorly understood because reliable animal models are limited. Therefore, we recently introduced a model of experimental murine AIH by a self-limited adenov...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Hardtke-Wolenski M,Dywicki J,Fischer K,Hapke M,Sievers M,Schlue J,Anderson MS,Taubert R,Noyan F,Manns MP,Jaeckel E

    更新日期:2017-03-01 00:00:00

  • Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

    abstract::Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

    更新日期:2012-06-01 00:00:00

  • Differences between normal and autoimmune T cell responses to autologous erythrocytes and haemoglobin: impairment of haptoglobin-mediated inhibition in NZB spleen cells.

    abstract::Helper T cells are required for development of the autoantibody responses to native mouse erythrocytes (MRBC) that spontaneously develop in NZB mice. However, the stimulus for these Th is not known. Therefore, we compared the abilities of splenic T cells from actively autoimmune old NZB mice and preautoimmune, young N...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Calkins CE,Esposito M

    更新日期:1996-08-01 00:00:00

  • The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.

    abstract::It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Harvey HA,Swords WE,Apicella MA

    更新日期:2001-05-01 00:00:00

  • IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.

    abstract::Congenital immune deficiency states have often been valuable experimental models of nature that have significantly enhanced our understanding of the immune response. The relationship between CD4+, CD25+ and Treg cells in the induction of autoimmunity has attracted significant attention. We report herein a male child o...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Aoki CA,Roifman CM,Lian ZX,Bowlus CL,Norman GL,Shoenfeld Y,Mackay IR,Gershwin ME

    更新日期:2006-08-01 00:00:00

  • Fine mapping of diabetes-associated IA-2 specific autoantibodies.

    abstract::The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Bearzatto M,Lampasona V,Belloni C,Bonifacio E

    更新日期:2003-12-01 00:00:00

  • Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

    abstract::Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expre...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Rattay K,Meyer HV,Herrmann C,Brors B,Kyewski B

    更新日期:2016-02-01 00:00:00

  • Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis.

    abstract::Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

    更新日期:2013-03-01 00:00:00

  • B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia.

    abstract::B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

    更新日期:2017-02-01 00:00:00

  • Sjögren's syndrome at the crossroad of polyautoimmunity.

    abstract::The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Amador-Patarroyo MJ,Arbelaez JG,Mantilla RD,Rodriguez-Rodriguez A,Cárdenas-Roldán J,Pineda-Tamayo R,Guarin MR,Kleine LL,Rojas-Villarraga A,Anaya JM

    更新日期:2012-09-01 00:00:00