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Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation.

Abstract：

:Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoimmune conditions. Despite its successful use in immunopathologies for over two decades, the precise mechanisms underlying the therapeutic benefit have not been fully elucidated. We and others have demonstrated that IVIg inhibits the antigen uptake and presentation by dendritic cells (DC). Here we report that IVIg-mediated inhibition of uptake and processing of antigens is associated with an increased accumulation of lipid as analyzed by flow cytometry and electron microscopy. As accumulation of lipids in DC is known to impart tolerogenic properties, these findings unravel novel link between antibodies and intracellular physiology of innate cells and may further uncover novel immunoregulatory mechanisms of IVIg in auto-inflammatory diseases.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Othy S,Bruneval P,Topçu S,Dugail I,Delers F,Lacroix-Desmazes S,Bayry J,Kaveri SV

doi

10.1016/j.jaut.2012.05.013

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

168-72

issue

3

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(12)00070-4

journal_volume

39

pub_type

杂志文章

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