The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.

abstract：:We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotoc...

journal_title：Journal of autoimmunity

authors： Khan NA,Yessoufou A,Kim M,Hichami A

更新日期：2006-06-01 00:00:00

abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

journal_title：Journal of autoimmunity

authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

更新日期：2012-06-01 00:00:00

abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

journal_title：Journal of autoimmunity

authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

更新日期：1995-10-01 00:00:00

abstract：:The development of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. We examine whether autoimmunity contributes independently to allograft rejection. In a MHC class II-mismatched murine model of chronic humoral rejection, we report that effector antinuclea...

journal_title：Journal of autoimmunity

authors： Qureshi MS,Alsughayyir J,Chhabra M,Ali JM,Goddard MJ,Devine CA,Conlon TM,Linterman MA,Motallebzadeh R,Pettigrew GJ

更新日期：2019-03-01 00:00:00

abstract：:Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

journal_title：Journal of autoimmunity

authors： Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

更新日期：2013-03-01 00:00:00

abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

journal_title：Journal of autoimmunity

authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

journal_title：Journal of autoimmunity

authors： Rimassa L,Personeni N,Aghemo A,Lleo A

更新日期：2019-06-01 00:00:00

abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

journal_title：Journal of autoimmunity

authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

更新日期：2004-06-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is associated with low serum immunoglobulin concentrations and an increased susceptibility to infections and autoimmune diseases. The treatment of choice for CVID patients is replacement intravenous immunoglobulin (IVIg) therapy. IVIg has been beneficial in preventing or allevia...

journal_title：Journal of autoimmunity

authors： Bayry J,Fournier EM,Maddur MS,Vani J,Wootla B,Sibéril S,Dimitrov JD,Lacroix-Desmazes S,Berdah M,Crabol Y,Oksenhendler E,Lévy Y,Mouthon L,Sautès-Fridman C,Hermine O,Kaveri SV

更新日期：2011-02-01 00:00:00

abstract：:Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expre...

journal_title：Journal of autoimmunity

authors： Rattay K,Meyer HV,Herrmann C,Brors B,Kyewski B

更新日期：2016-02-01 00:00:00

abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

journal_title：Journal of autoimmunity

authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

更新日期：2009-08-01 00:00:00

abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

journal_title：Journal of autoimmunity

authors： Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

更新日期：1989-06-01 00:00:00

abstract：:In contrast to several previously published reports, we demonstrate by a variety of antibody assays that bovine serum albumin (BSA) is not antigenically cross-reactive with the 69-kDa islet cell autoantigen (ICA69). Fast protein liquid chromatography purified BSA and highly purified recombinant human ICA69 were used t...

journal_title：Journal of autoimmunity

authors： Rønningen KS,Atrazhev A,Luo L,Luo C,Smith DK,Korbutt G,Rajotte RV,Elliott JF

更新日期：1998-06-01 00:00:00

abstract：:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

journal_title：Journal of autoimmunity

authors： Sonoda Y

更新日期：2008-05-01 00:00:00

abstract：:IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

journal_title：Journal of autoimmunity

authors： Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

更新日期：1996-06-01 00:00:00

abstract：:Solute carrier family 11 member a1 (SLC11A1) exerts pleiotropic effects on macrophage function. Expression of SLC11A1 is regulated by a (GT)(n) microsatellite promoter repeat polymorphism of which nine alleles have been described. Enhanced activation of macrophages, associated with increased expression from allele 3, ...

journal_title：Journal of autoimmunity

authors： O'Brien BA,Archer NS,Simpson AM,Torpy FR,Nassif NT

更新日期：2008-08-01 00:00:00

abstract：:Isolated congenital heart block may be associated with autoimmune disorder such as Sjögren Syndrome and systemic lupus erythematosus. In this work we demonstrate circulating autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor (mAChR) in the sera of children with congenital heart block. This anti...

journal_title：Journal of autoimmunity

authors： Borda E,Sterin-Borda L

更新日期：2001-03-01 00:00:00

abstract：:With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by immune activation, vascular complications, and excessive fibrosis in internal organs. Genetic studies, including candidate gene association studies, genome-wide association studies, and whole-exome sequencing have supported the notion ...

journal_title：Journal of autoimmunity

authors： Tsou PS,Sawalha AH

更新日期：2017-09-01 00:00:00

abstract：:Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

journal_title：Journal of autoimmunity

authors： Gleicher N,Barad DH

更新日期：2007-02-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characteristized by the presence of autoantibodies against double-stranded DNA (anti-dsDNA) in sera at high levels. Bacterial infections in SLE are associated with higher morbidity and mortality. Our goal was to observe the interaction between thes...

journal_title：Journal of autoimmunity

authors： Lee TP,Tang SJ,Wu MF,Song YC,Yu CL,Sun KH

更新日期：2010-12-01 00:00:00

abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

journal_title：Journal of autoimmunity

authors： Chu CQ,Londei M

更新日期：1999-02-01 00:00:00

abstract：:The F1 progeny of the cross between SWR and NZB mice (SNF1) develop severe immune complex glomerulonephritis, similar to that seen in human SLE. An idiotypically-related family of nephritic antibodies (IdLNF1) has been shown to be important in the pathogenesis of autoimmune glomerulonephritis in these mice. Interestin...

journal_title：Journal of autoimmunity

authors： Uner AH,Knupp CJ,Tatum AH,Gavalchin J

更新日期：1994-02-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

journal_title：Journal of autoimmunity

authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

更新日期：1990-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

journal_title：Journal of autoimmunity

authors： Fava A,Petri M

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To identify potential causative markers involved in the development of early-onset myasthenia gravis (EOMG) in the MHC and non-MHC regions that may interact with the HLA-B*08:01 allele. METHODS:We analyzed 583 MG patients and identified 5 patients homozygous for the disease-associated ancestral haplotype 8.1...

journal_title：Journal of autoimmunity

authors： Varade J,Wang N,Lim CK,Zhang T,Zhang Y,Liu X,Piehl F,Matell R,Cao H,Xu X,Hammarström L

更新日期：2018-03-01 00:00:00

abstract：:T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu...

journal_title：Journal of autoimmunity

authors： Chang JC,Linarelli LG,Laxer JA,Froning KJ,Caralli LL,Brostoff SW,Carlo DJ

更新日期：1995-04-01 00:00:00

abstract：:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered,...

journal_title：Journal of autoimmunity

authors： Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

更新日期：2012-12-01 00:00:00

abstract：:We have investigated the pathophysiological basis of cardiac dysfunction in autoimmune myocarditis and in the resulting dilated cardiomyopathy. To this end we utilized the myosin-induced autoimmune myocarditis model in BALB/c mice. Myocarditis has been found to be associated with massive ventricular lymphocyte infiltr...

journal_title：Journal of autoimmunity

authors： Less H,Shilkrut M,Rubinstein I,Berke G,Binah O

更新日期：1999-05-01 00:00:00