Characterization of two anti-DNA antibodies bearing distinct idiotypes. Correlation with clinical manifestations.

Abstract:

:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing higher specific antigen-binding activity and avidity to DNA and presenting more cationic quality upon isoelectric focusing and Western blot analysis than the ones found in patients without renal involvement. Lupus cerebritis was associated with anti-DNA antibodies with different idiotypic characteristics not shared by anti-DNA antibodies present in lupus nephritis. Lupus cerebritis anti-DNA antibodies had less specific antigen-binding activity and avidity to DNA and did not show cationic quality. Idiotypic and immunochemical changes of anti-DNA antibodies in lupus may be associated with various clinical manifestations.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Suenaga R,Munoz PA,Hon SH,Abdou NI

doi

10.1016/0896-8411(89)90271-0

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

297-306

issue

3

eissn

0896-8411

issn

1095-9157

pii

0896-8411(89)90271-0

journal_volume

2

pub_type

杂志文章
  • Characterization of anti-phosphatidylcholine polyreactive natural autoantibodies from normal human subjects.

    abstract::In 1990 our group reported a patient with autoimmune hemolytic anemia and high titers of IgM anticardiolipin antibodies that cross-reacted with phosphatidylcholine (PTC). These autoantibodies also recognized bromelain-treated erythrocytes (BrE) and in vitro aged erythrocytes. The epitope exposed with this treatment is...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.2001.0575

    authors: Cabiedes J,Cabral AR,López-Mendoza AT,Cordero-Esperón HA,Huerta MT,Alarcón-Segovia D

    更新日期:2002-03-01 00:00:00

  • Systemic lupus erythematosus: Diagnosis and clinical management.

    abstract::Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2018.11.001

    authors: Fava A,Petri M

    更新日期:2019-01-01 00:00:00

  • Structure-function studies on beta 2-glycoprotein I.

    abstract::Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprote...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1006/jaut.2000.0394

    authors: de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P

    更新日期:2000-09-01 00:00:00

  • Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-α use in females with immune mediated diseases; a systematic review and meta-analysis.

    abstract:BACKGROUND:Immune mediated diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD) commonly affect young and adolescent females. Anti-tumor necrosis factor (TNF)-α agents are increasingly used to treat these conditions, but their safety during pregnancy remains uncl...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jaut.2016.11.004

    authors: Komaki F,Komaki Y,Micic D,Ido A,Sakuraba A

    更新日期:2017-01-01 00:00:00

  • Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

    abstract::The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors participating in the breakdown of tolerance. A unique opportunity to study the pathogenesis of human autoimmunity is provided by autoimmune polyendocrinopathy-candidiasis-ectoder...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2010.07.008

    authors: Laakso SM,Laurinolli TT,Rossi LH,Lehtoviita A,Sairanen H,Perheentupa J,Kekäläinen E,Arstila TP

    更新日期:2010-12-01 00:00:00

  • Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.

    abstract::Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(89)90117-0

    authors: June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

    更新日期:1989-06-01 00:00:00

  • Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats.

    abstract::The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1998.0205

    authors: Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

    更新日期:1998-08-01 00:00:00

  • Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes.

    abstract::The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(91)90055-h

    authors: Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

    更新日期:1991-12-01 00:00:00

  • The top ten clues to understand the origin of chronic lymphocytic leukemia (CLL).

    abstract::The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2014.10.005

    authors: García-Muñoz R,Feliu J,Llorente L

    更新日期:2015-01-01 00:00:00

  • Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis.

    abstract::Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2005.05.007

    authors: Horwitz MS,Ilic A,Fine C,Sarvetnick N

    更新日期:2005-09-01 00:00:00

  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

    abstract::Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2020.102462

    authors: Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

    更新日期:2020-08-01 00:00:00

  • Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes.

    abstract::Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characteristized by the presence of autoantibodies against double-stranded DNA (anti-dsDNA) in sera at high levels. Bacterial infections in SLE are associated with higher morbidity and mortality. Our goal was to observe the interaction between thes...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2010.07.007

    authors: Lee TP,Tang SJ,Wu MF,Song YC,Yu CL,Sun KH

    更新日期:2010-12-01 00:00:00

  • Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

    abstract:OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2019.04.001

    authors: Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

    更新日期:2019-07-01 00:00:00

  • Autoantibody explosion in antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss in the presence of antiphospholipid antibodies (aPL), mainly anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant. However, similar to systemic lupus erythematosus, APS is also characterized by multiple other autoantibodies...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2007.11.011

    authors: Shoenfeld Y,Twig G,Katz U,Sherer Y

    更新日期:2008-02-01 00:00:00

  • Hu antigen specificities of ANNA-I autoantibodies in paraneoplastic neurological disease.

    abstract::Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1999.0337

    authors: King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

    更新日期:1999-12-01 00:00:00

  • A role for MHC class II antigens in B-cell activation.

    abstract::Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(89)90133-9

    authors: Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

    更新日期:1989-06-01 00:00:00

  • Immunoblotting for the detection of TSH receptor autoantibodies.

    abstract::Immunoblotting was optimized to detect autoantibodies to TSH receptors from human and porcine thyroid tissue and to determine their epitope specificity. Autoantibodies to putative TSH receptor proteins in thyroid particulate membranes were detected in approximately 35% of sera from patients with Graves' disease. Howev...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(91)90164-8

    authors: Leedman PJ,Harrison PJ,Harrison LC

    更新日期:1991-06-01 00:00:00

  • 1,25 dihydroxyvitamin-D3 regulation of immunoglobulin production in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

    abstract::Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the secretion of autoantibodies. The mechanisms of autoantibody-induced disease have not been clarified. 1,25-Dihydroxy-vitamin D3 (1,25-D3) is known to be important in the regulation of normal human lymphocyte functions. Among...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(89)90012-7

    authors: Chong PJ,Matzner WL,Wallace DJ,Klinenberg JR,Toyoda M,Jordan SC

    更新日期:1989-12-01 00:00:00

  • Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

    abstract::Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1998.0255

    authors: Chu CQ,Londei M

    更新日期:1999-02-01 00:00:00

  • gammadelta T cells express activation markers in the central nervous system of mice with chronic-relapsing experimental autoimmune encephalomyelitis.

    abstract::In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.2001.0547

    authors: Gao YL,Rajan AJ,Raine CS,Brosnan CF

    更新日期:2001-12-01 00:00:00

  • Analysis of the cell populations composing the mononuclear cell infiltrates in the labial minor salivary glands from patients with rheumatoid arthritis and sicca syndrome.

    abstract:OBJECTIVES:Sicca symptoms occur in around 30% of rheumatoid arthritis (RA) patients. Herein, we examined the characteristics of RA patients bearing sicca symptomatology (RA-sicca) with a special focus on the immunohistopathological features of their labial minor salivary gland (LMSG) biopsies. METHODS:Our cohort inclu...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2016.06.008

    authors: Fragoulis GE,Fragkioudaki S,Reilly JH,Kerr SC,McInnes IB,Moutsopoulos HM

    更新日期:2016-09-01 00:00:00

  • Fine mapping of diabetes-associated IA-2 specific autoantibodies.

    abstract::The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2003.08.002

    authors: Bearzatto M,Lampasona V,Belloni C,Bonifacio E

    更新日期:2003-12-01 00:00:00

  • Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

    abstract::Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2014.12.005

    authors: Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

    更新日期:2015-02-01 00:00:00

  • 'Classic' anti-neutrophil cytoplasmic autoantibodies (cANCA), 'Wegener's autoantigen' and their immunopathogenic role in Wegener's granulomatosis.

    abstract::Wegener's autoantigen (WA), a 29 kD multifunctional protein, is the principal target antigen of autoantibodies associated with Wegener's granulomatosis (WG). WA was first identified as proteinase 3 (PR3), which is now known to be identical with myeloblastin and AGP7. Like other lysosomal proteins, WA/PR3 displays enzy...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1006/jaut.1993.1015

    authors: Gross WL,Csernok E,Flesch BK

    更新日期:1993-04-01 00:00:00

  • Autoantibody repertoire to Ro/SSA and La/SSB antigens in patients with primary and secondary Sjögren's syndrome.

    abstract::Autoimmune diseases are characterized serologically by the presence of antibodies to specific autoantigens. Antibodies to the two antigens Ro/SSA and La/SSB are found in patients with primary (pSS) and secondary Sjögren's syndrome (sSS). To explore if differences in the fine specificity of these autoantibodies could b...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1996.0072

    authors: Wahren M,Solomin L,Pettersson I,Isenberg D

    更新日期:1996-08-01 00:00:00

  • Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.

    abstract::Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2008.08.009

    authors: Liu Z,Sui W,Zhao M,Li Z,Li N,Thresher R,Giudice GJ,Fairley JA,Sitaru C,Zillikens D,Ning G,Marinkovich MP,Diaz LA

    更新日期:2008-12-01 00:00:00

  • NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.

    abstract::The induction and persistence of a hypo-inflammatory and immunosuppressive state in severe sepsis is commonly associated with increased risks of secondary infections and mortality. Toll-like receptor (TLR)-triggered inflammatory response of macrophages/monocytes plays an important role in determining the outcome of hy...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2017.04.006

    authors: Qin K,Han C,Zhang H,Li T,Li N,Cao X

    更新日期:2017-07-01 00:00:00

  • IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients.

    abstract::Autoimmunity mediated by IgG4 subclass autoantibodies is an expanding field of research. Due to their structural characteristics a key feature of IgG4 antibodies is the ability to exchange Fab-arms with other, unrelated, IgG4 molecules, making the IgG4 molecule potentially monovalent for the specific antigen. However,...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2016.11.005

    authors: Koneczny I,Stevens JA,De Rosa A,Huda S,Huijbers MG,Saxena A,Maestri M,Lazaridis K,Zisimopoulou P,Tzartos S,Verschuuren J,van der Maarel SM,van Damme P,De Baets MH,Molenaar PC,Vincent A,Ricciardi R,Martinez-Martinez P,

    更新日期:2017-02-01 00:00:00

  • The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.

    abstract::Sjögren's syndrome (SS) is a chronic autoimmune disorder that is characterized by dysfunction and destruction of the exocrine glands. Exocrinopathy is associated with periductal mononuclear cell infiltrates in the affected exocrine glands and B-cell hyperreactivity. Epithelial cells are thought to play an important pa...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2010.06.011

    authors: Manoussakis MN,Kapsogeorgou EK

    更新日期:2010-11-01 00:00:00

  • The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted.

    abstract::The major targets of the disease-specific autoantibodies to citrullinated proteins (ACPA) in synovium of rheumatoid arthritis (RA) patients are borne by the citrullinated α- and β-chains of fibrin. We demonstrated that ACPA target a limited set of citrullinated fibrin peptides and particularly four multicitrullinated ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2011.07.003

    authors: Iobagiu C,Magyar A,Nogueira L,Cornillet M,Sebbag M,Arnaud J,Hudecz F,Serre G

    更新日期:2011-12-01 00:00:00