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Characterization of two anti-DNA antibodies bearing distinct idiotypes. Correlation with clinical manifestations.

Abstract：

:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing higher specific antigen-binding activity and avidity to DNA and presenting more cationic quality upon isoelectric focusing and Western blot analysis than the ones found in patients without renal involvement. Lupus cerebritis was associated with anti-DNA antibodies with different idiotypic characteristics not shared by anti-DNA antibodies present in lupus nephritis. Lupus cerebritis anti-DNA antibodies had less specific antigen-binding activity and avidity to DNA and did not show cationic quality. Idiotypic and immunochemical changes of anti-DNA antibodies in lupus may be associated with various clinical manifestations.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Suenaga R,Munoz PA,Hon SH,Abdou NI

doi

10.1016/0896-8411(89)90271-0

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

297-306

issue

3

eissn

0896-8411

issn

1095-9157

pii

0896-8411(89)90271-0

journal_volume

2

pub_type

杂志文章

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