Characterization of two anti-DNA antibodies bearing distinct idiotypes. Correlation with clinical manifestations.


:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing higher specific antigen-binding activity and avidity to DNA and presenting more cationic quality upon isoelectric focusing and Western blot analysis than the ones found in patients without renal involvement. Lupus cerebritis was associated with anti-DNA antibodies with different idiotypic characteristics not shared by anti-DNA antibodies present in lupus nephritis. Lupus cerebritis anti-DNA antibodies had less specific antigen-binding activity and avidity to DNA and did not show cationic quality. Idiotypic and immunochemical changes of anti-DNA antibodies in lupus may be associated with various clinical manifestations.


J Autoimmun


Journal of autoimmunity


Suenaga R,Munoz PA,Hon SH,Abdou NI




Has Abstract


1989-06-01 00:00:00














  • Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

    abstract::Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

    更新日期:2017-01-01 00:00:00

  • Autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor in children with congenital heart block.

    abstract::Isolated congenital heart block may be associated with autoimmune disorder such as Sjögren Syndrome and systemic lupus erythematosus. In this work we demonstrate circulating autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor (mAChR) in the sera of children with congenital heart block. This anti...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Borda E,Sterin-Borda L

    更新日期:2001-03-01 00:00:00

  • Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69.

    abstract::In contrast to several previously published reports, we demonstrate by a variety of antibody assays that bovine serum albumin (BSA) is not antigenically cross-reactive with the 69-kDa islet cell autoantigen (ICA69). Fast protein liquid chromatography purified BSA and highly purified recombinant human ICA69 were used t...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Rønningen KS,Atrazhev A,Luo L,Luo C,Smith DK,Korbutt G,Rajotte RV,Elliott JF

    更新日期:1998-06-01 00:00:00

  • Infections as risk factor for autoimmune diseases - A nationwide study.

    abstract::Viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. In the present nation-wide study we describe the association between infections and 29 autoimmune diseases. We used the Danish Civil Registration System to identify 4.5 million persons born between 1945 an...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Nielsen PR,Kragstrup TW,Deleuran BW,Benros ME

    更新日期:2016-11-01 00:00:00

  • Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis.

    abstract::Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

    更新日期:2013-03-01 00:00:00

  • The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.

    abstract::Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Pearson JA,Wong FS,Wen L

    更新日期:2016-01-01 00:00:00

  • Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study.

    abstract::In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

    更新日期:2000-03-01 00:00:00

  • Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1.

    abstract::Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

    更新日期:2001-09-01 00:00:00

  • IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.

    abstract::Congenital immune deficiency states have often been valuable experimental models of nature that have significantly enhanced our understanding of the immune response. The relationship between CD4+, CD25+ and Treg cells in the induction of autoimmunity has attracted significant attention. We report herein a male child o...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Aoki CA,Roifman CM,Lian ZX,Bowlus CL,Norman GL,Shoenfeld Y,Mackay IR,Gershwin ME

    更新日期:2006-08-01 00:00:00

  • Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.

    abstract:OBJECTIVE:To identify potential causative markers involved in the development of early-onset myasthenia gravis (EOMG) in the MHC and non-MHC regions that may interact with the HLA-B*08:01 allele. METHODS:We analyzed 583 MG patients and identified 5 patients homozygous for the disease-associated ancestral haplotype 8.1...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Varade J,Wang N,Lim CK,Zhang T,Zhang Y,Liu X,Piehl F,Matell R,Cao H,Xu X,Hammarström L

    更新日期:2018-03-01 00:00:00

  • Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals.

    abstract::A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

    更新日期:2014-05-01 00:00:00

  • Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.

    abstract::HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by whi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Behrens M,Trejo T,Luthra H,Griffiths M,David CS,Taneja V

    更新日期:2010-08-01 00:00:00

  • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

    abstract::IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

    更新日期:1996-06-01 00:00:00

  • Patients with bullous pemphigoid and linear IgA disease show a dual IgA and IgG autoimmune response to BP180.

    abstract::Bullous pemphigoid (BP) and linear IgA disease (LAD) are autoimmune subepidermal blistering skin diseases associated with autoantibodies against the transmembrane hemidesmosomal protein BP180/type XVII collagen. It has been demonstrated previously that BP is characterized predominantly by IgG autoantibodies, while aut...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Kromminga A,Scheckenbach C,Georgi M,Hagel C,Arndt R,Christophers E,Bröcker EB,Zillikens D

    更新日期:2000-11-01 00:00:00

  • Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B.

    abstract::To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Vento S,McFarlane BM,Vento TG,Ranieri S,Rondanelli EG,McFarlane IG,Williams R,Eddleston AL

    更新日期:1988-06-01 00:00:00

  • Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease.

    abstract::The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Xu C,Wu F,Mao C,Wang X,Zheng T,Bu L,Mou X,Zhou Y,Yuan G,Wang S,Xiao Y

    更新日期:2016-12-01 00:00:00

  • Sjögren's syndrome at the crossroad of polyautoimmunity.

    abstract::The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Amador-Patarroyo MJ,Arbelaez JG,Mantilla RD,Rodriguez-Rodriguez A,Cárdenas-Roldán J,Pineda-Tamayo R,Guarin MR,Kleine LL,Rojas-Villarraga A,Anaya JM

    更新日期:2012-09-01 00:00:00

  • Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

    abstract::Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Bonam SR,Wang F,Muller S

    更新日期:2018-11-01 00:00:00

  • The top ten clues to understand the origin of chronic lymphocytic leukemia (CLL).

    abstract::The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: García-Muñoz R,Feliu J,Llorente L

    更新日期:2015-01-01 00:00:00

  • Effects of oral administration of malathion on the course of disease in MRL-lpr mice.

    abstract::Malathion administration at non-cholinergical doses was shown to elevate macrophage, proliferative and humoral immune responses. This study examined the effects of malathion on autoimmunity, autoantibody formation, macrophage function and mitogenic responses in MRL-lpr mice (genetically predisposed to autoimmune disea...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Rodgers KE

    更新日期:1997-08-01 00:00:00

  • Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis.

    abstract::Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

    更新日期:2004-06-01 00:00:00

  • Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism.

    abstract:OBJECTIVE:We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). METHODS:From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: de Faire U,Su J,Hua X,Frostegård A,Halldin M,Hellenius ML,Wikström M,Dahlbom I,Grönlund H,Frostegård J

    更新日期:2010-03-01 00:00:00

  • Different dysregulations of the natural antibody repertoire in treated and untreated HIV-1 patients.

    abstract::To investigate a possible dysregulation of the autoantibody network in AIDS patients, the relative activity of representative natural antibodies was measured in serum IgG and IgM. These immunoglobulins were purified from two cohorts of 20 HIV-infected patients undergoing, or not, a triple combination therapy. A cohort...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Quan CP,Watanabe S,Pamonsinlapatham P,Bouvet JP

    更新日期:2001-08-01 00:00:00

  • Sex bias in paediatric autoimmune disease - Not just about sex hormones?

    abstract::Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Chiaroni-Clarke RC,Munro JE,Ellis JA

    更新日期:2016-05-01 00:00:00

  • Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis.

    abstract:OBJECTIVE:To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. METHODS:Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compare...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Leclercq M,Langlois V,Girszyn N,Le Besnerais M,Benhamou Y,Levesque H,Muraine M,Gueudry J

    更新日期:2020-09-01 00:00:00

  • Phosphorylation abnormalities: NZB mice exhibit a B-cell signalling defect.

    abstract::NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

    更新日期:2002-11-01 00:00:00

  • Post-thymic tolerance to self antigens.

    abstract::There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审


    authors: Miller JF

    更新日期:1992-04-01 00:00:00

  • Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells.

    abstract::The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

    更新日期:1994-04-01 00:00:00

  • Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.

    abstract::Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

    更新日期:2000-02-01 00:00:00

  • Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant.

    abstract::The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章


    authors: Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

    更新日期:1990-12-01 00:00:00