Elimination of infectious antigens and increase of IgG catabolism as possible modes of action of IVIg.

abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

journal_title：Journal of autoimmunity

authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

更新日期：2006-08-01 00:00:00

abstract：:It has been recently suggested that primary Sjögren's syndrome (SS) patients present with a variety of personality structure disturbances and psychiatric symptoms. To evaluate this finding further, we assessed hostility structure and psychiatric symptoms in 33 Sjögren's syndrome patients and compared the results with ...

journal_title：Journal of autoimmunity

authors： Drosos AA,Angelopoulos NV,Liakos A,Moutsopoulos HM

更新日期：1989-08-01 00:00:00

abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

journal_title：Journal of autoimmunity

authors： Derksen RH,de Groot PG

更新日期：2000-09-01 00:00:00

abstract：:The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) expression profiles were analysed in tissues with differing disease st...

journal_title：Journal of autoimmunity

authors： Clanchy FIL,Borghese F,Bystrom J,Balog A,Penn H,Hull DN,Wells GMA,Kiriakidis S,Taylor PC,Sacre SM,Williams LM,Stone TW,Mageed RA,Williams RO

更新日期：2021-01-22 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy preferentially depletes intrahepatic regula...

journal_title：Journal of autoimmunity

authors： Buitrago-Molina LE,Pietrek J,Noyan F,Schlue J,Manns MP,Wedemeyer H,Hardtke-Wolenski M,Jaeckel E

更新日期：2021-02-01 00:00:00

abstract：:The Foxp3(+)CD4(+) regulatory T-cell (Treg)-deficient Scurfy (Sf) mice rapidly develop severe inflammation in the skin and lungs with expanded Th subsets bearing increased expression of various chemokine/chemoattractant/retention receptor genes (CRG). Nine different double mutants were generated to elucidate their rol...

journal_title：Journal of autoimmunity

authors： Sharma R,Sung SS,Gaskin F,Fu SM,Ju ST

更新日期：2012-06-01 00:00:00

abstract：:The specific contributions of islet cell microenvironment during the development of autoimmune type 1 diabetes remain unclear. The aims of this study were to identify early immune-driven abnormalities in islets and pancreatic lymph nodes of NOD mice by cDNA arrays. We compared gene expression profiles of purified isle...

journal_title：Journal of autoimmunity

authors： Aspord C,Rome S,Thivolet C

更新日期：2004-08-01 00:00:00

abstract：:Autoantibodies to adrenal medulla that gave a diffuse immunofluorescent staining pattern were detected in 17 out of 107 (16%) patients with newly diagnosed Type I diabetes mellitus, in 13 out of 178 (7%) patients with long lasting disease but in none of 80 mixed control sera tested. The antibodies were of IgG class an...

journal_title：Journal of autoimmunity

authors： Scherbaum WA,Mogel H,Boehm BO,Hedderich U,Glück M,Schernthaner G,Bottazzo GF,Pfeiffer EF

更新日期：1988-06-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

journal_title：Journal of autoimmunity

authors： Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

更新日期：2001-09-01 00:00:00

abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

journal_title：Journal of autoimmunity

authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

更新日期：2014-05-01 00:00:00

abstract：:This paper describes some of the methodological problems related to the measurement of cyclosporin. The clinical value of the measurements following organ transplantation are discussed and those areas also applying to autoimmune indications are highlighted. It is concluded that the routine use of cyclosporin monitorin...

journal_title：Journal of autoimmunity

authors： Holt DW,Johnston A

更新日期：1992-04-01 00:00:00

abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

journal_title：Journal of autoimmunity

authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

journal_title：Journal of autoimmunity

authors： Reddy S,Wu D,Poole CA

更新日期：1996-02-01 00:00:00

abstract：:Among B/W-derived IgM mAb, 12.5H was selected because of its ability to recognize, in solid phase ELISAs, IgG mAb with DNA-binding activity. mAb 12.5H bound preferentially to IgG2a mAb and did not react with B/W- or BALB/c-derived IgG2a mAb with no DNA-binding activity, suggesting V region-mediated interactions. mAb 1...

journal_title：Journal of autoimmunity

authors： Margaritte C,Gilbert D,Brard F,Tron F

更新日期：1994-12-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain de...

journal_title：Journal of autoimmunity

authors： Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix H

更新日期：1991-04-01 00:00:00

abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

journal_title：Journal of autoimmunity

authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

更新日期：2019-01-01 00:00:00

abstract：:The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

journal_title：Journal of autoimmunity

authors： Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

更新日期：1994-04-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto thyroiditis (HT), are the most prevalent organ-specific autoimmune diseases, but their pathogenesis is still incompletely understood. The PD-1/PD-L1 pathway is an important mechanism of peripheral tolerance that has not been investigated in ...

journal_title：Journal of autoimmunity

authors： Álvarez-Sierra D,Marín-Sánchez A,Ruiz-Blázquez P,de Jesús Gil C,Iglesias-Felip C,González Ó,Casteras A,Costa RF,Nuciforo P,Colobran R,Pujol-Borrell R

更新日期：2019-09-01 00:00:00

abstract：:Several polymorphisms of the insulin gene and its flanking regions (INS region) are in linkage disequilibrium and confer susceptibility to insulin-dependent diabetes (IDDM). We have analysed INS AA and AB-BB genotypes at the 1,428 FokI site (3' of the insulin gene) in 217 patients with IDDM, 402 non-diabetic first deg...

journal_title：Journal of autoimmunity

authors： Pugliese A,Awdeh ZL,Alper CA,Jackson RA,Eisenbarth GS

更新日期：1994-10-01 00:00:00

abstract：:TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha early in life experience an acceleration in disease onset while TNF-alpha administered to adult NOD mice are ...

journal_title：Journal of autoimmunity

authors： Middlebrook AJ,Lebsack T,DeLuca D

更新日期：2007-09-01 00:00:00

abstract：:Immunoglobulins (Ig) or antibodies are heavy plasma proteins, with sugar chains added to amino acid residues by N-linked glycosylation and occasionally by O-linked glycosylation. The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation wit...

journal_title：Journal of autoimmunity

authors： Wootla B,Lacroix-Desmazes S,Warrington AE,Bieber AJ,Kaveri SV,Rodriguez M

更新日期：2011-09-01 00:00:00

abstract：:The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved methods of detection and advanced laboratory methodology. Patients with PIDs have an increased...

journal_title：Journal of autoimmunity

authors： Amaya-Uribe L,Rojas M,Azizi G,Anaya JM,Gershwin ME

更新日期：2019-05-01 00:00:00

abstract：:The adrenocortical response is central to recovery from experimental allergic encephalomyelitis (EAE) in the Lewis rat, as reflected by the increased severity of the disease in adrenalectomized animals. The protection conferred by glucocorticoids is related to the immunosuppressive effects of the steroid, which may in...

journal_title：Journal of autoimmunity

authors： Smith T,Schmied M,Hewson AK,Lassmann H,Cuzner ML

更新日期：1996-04-01 00:00:00

abstract：:Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

journal_title：Journal of autoimmunity

authors： Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

更新日期：2000-02-01 00:00:00

abstract：:A recent report identified two islet cell cytoplasmic antibody subclasses using an immunohistochemical method. The islet cell cytoplasmic antibody subclass which reacts with only Beta-cells was termed 'Beta-cell islet cell cytoplasmic antibodies' and another islet cell cytoplasmic antibody subclass which reacts with B...

journal_title：Journal of autoimmunity

authors： Takino H,Kawasaki E,Yano M,Matsumoto K,Uotani S,Okuno S,Takao Y,Yamasaki H,Yamaguchi Y,Akazawa S

更新日期：1994-06-01 00:00:00

abstract：:Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven groups of 3-month-old female BALB/cJ mice received a single intraperi...

journal_title：Journal of autoimmunity

authors： Satoh M,Kuroda Y,Yoshida H,Behney KM,Mizutani A,Akaogi J,Nacionales DC,Lorenson TD,Rosenbauer RJ,Reeves WH

更新日期：2003-08-01 00:00:00

abstract：:Malathion administration at non-cholinergical doses was shown to elevate macrophage, proliferative and humoral immune responses. This study examined the effects of malathion on autoimmunity, autoantibody formation, macrophage function and mitogenic responses in MRL-lpr mice (genetically predisposed to autoimmune disea...

journal_title：Journal of autoimmunity

authors： Rodgers KE

更新日期：1997-08-01 00:00:00

abstract：:An experimental model of two interacting clones of T cells is described, which may be used for defining and exploring the T-cell immunoregulatory network. Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 MoAbs activate and induce cell prolif...

journal_title：Journal of autoimmunity

authors： Naor D,Essery G,Kahan M,Feldmann M

更新日期：1989-06-01 00:00:00

abstract：:Following the mass vaccinations against pandemic influenza A/H1N1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic neurological disorder characterized by excessive daytime ...

journal_title：Journal of autoimmunity

authors： Saariaho AH,Vuorela A,Freitag TL,Pizza F,Plazzi G,Partinen M,Vaarala O,Meri S

更新日期：2015-09-01 00:00:00