Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study.

abstract：:Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppress...

journal_title：Journal of autoimmunity

authors： Rosenzwajg M,Churlaud G,Mallone R,Six A,Dérian N,Chaara W,Lorenzon R,Long SA,Buckner JH,Afonso G,Pham HP,Hartemann A,Yu A,Pugliese A,Malek TR,Klatzmann D

更新日期：2015-04-01 00:00:00

abstract：:There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

journal_title：Journal of autoimmunity

authors： Miller JF

更新日期：1992-04-01 00:00:00

abstract：:Beta(2)-glycoprotein I (beta(2)GPI) is known as a major autoantigen for antiphospholipid antibodies. Our recent data show that binding of beta(2)GPI to oxidized low-density lipoprotein (oxLDL) or to liposomes containing anionic phospholipid(s) may facilitate the presentation of beta(2)GPI's epitope by macrophages/dend...

journal_title：Journal of autoimmunity

authors： Kajiwara T,Yasuda T,Matsuura E

更新日期：2007-09-01 00:00:00

abstract：:Ro52 is a common target of circulating autoantibodies in autoimmune disease. Data indicate that anti-Ro52 antibodies are associated with distinct clinical manifestations. It is therefore of major interest to understand how it becomes an antigenic target and what cells express this protein under what conditions and wha...

journal_title：Journal of autoimmunity

authors： Oke V,Wahren-Herlenius M

更新日期：2012-08-01 00:00:00

abstract：:Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

journal_title：Journal of autoimmunity

authors： Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

更新日期：2007-06-01 00:00:00

abstract：:Polymyositis is classified as a separate entity among idiopathic inflammatory myopathies but it is considered as the least common since it is an exclusion diagnosis. This myopathy usually presents with subacute-chronic symmetric proximal limb weakness, although some extramuscular manifestations are common. Creatine ki...

journal_title：Journal of autoimmunity

authors： Milisenda JC,Selva-O'Callaghan A,Grau JM

更新日期：2014-02-01 00:00:00

abstract：:University of California at Davis (UCD) lines 200 and 206 chickens develop a hereditary systemic scleroderma-like connective tissue disease characterized by severe lymphocytic infiltration and excessive accumulation of collagen in skin and internal organs. The immune system seems to play an important role in the devel...

journal_title：Journal of autoimmunity

authors： Sgonc R,Dietrich H,Gershwin ME,Colombatti A,Wick G

更新日期：1995-10-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoim...

journal_title：Journal of autoimmunity

authors： Othy S,Bruneval P,Topçu S,Dugail I,Delers F,Lacroix-Desmazes S,Bayry J,Kaveri SV

更新日期：2012-09-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is implicated as a mediator of islet beta-cell destruction in autoimmune, insulin-dependent diabetes mellitus (IDDM). Because interleukin 12 (IL-12) is a potent inducer of IFN-gamma production, we sought evidence implicating IL-12 in IDDM development. In the present study, we used a revers...

journal_title：Journal of autoimmunity

authors： Rabinovitch A,Suarez-Pinzon WL,Sorensen O

更新日期：1996-10-01 00:00:00

abstract：:Primary warm autoimmune hemolytic anemia (wAIHA) is a rare autoimmune disease in which red blood cells are eliminated by IgG autoantibodies. We analyzed the antibody-secreting cells in the spleen and the peripheral blood of wAIHA patients in various contexts of treatment. Plasmablasts were observed in peripheral blood...

journal_title：Journal of autoimmunity

authors： Mahévas M,Michel M,Vingert B,Moroch J,Boutboul D,Audia S,Cagnard N,Ripa J,Menard C,Tarte K,Mégret J,Le Gallou S,Patin P,Thai L,Galicier L,Bonnotte B,Godeau B,Noizat-Pirenne F,Weill JC,Reynaud CA

更新日期：2015-08-01 00:00:00

abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now e...

journal_title：Journal of autoimmunity

authors： Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

更新日期：2014-02-01 00:00:00

abstract：:Glutamic acid decarboxylase 65 (GAD65) is a putative autoantigen associated with the pathogenesis of type 1 diabetes (T1D). The prevalence of autoreactive CD4+ T cells towards the immunodominant GAD65(555-567) epitope in DR4 healthy and T1D subjects was investigated with class II tetramers. A slightly higher percentag...

journal_title：Journal of autoimmunity

authors： Danke NA,Yang J,Greenbaum C,Kwok WW

更新日期：2005-12-01 00:00:00

abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

journal_title：Journal of autoimmunity

authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

更新日期：2012-06-01 00:00:00

abstract：:The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an infectious disease caused by SARS-CoV-2, which causes pneumonia, requires intensive care unit hospitalization in about 10% of cases and can lead to ...

journal_title：Journal of autoimmunity

authors： Perricone C,Triggianese P,Bartoloni E,Cafaro G,Bonifacio AF,Bursi R,Perricone R,Gerli R

更新日期：2020-07-01 00:00:00

abstract：:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addi...

journal_title：Journal of autoimmunity

authors： Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

更新日期：1992-08-01 00:00:00

abstract：:Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient with PBC with the mouse human heterohybrid cell line F3B6. Previ...

journal_title：Journal of autoimmunity

authors： Leung PS,Krams S,Munoz S,Surh CP,Ansari A,Kenny T,Robbins DL,Fung J,Starzl TE,Maddrey W

更新日期：1992-12-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

journal_title：Journal of autoimmunity

authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

journal_title：Journal of autoimmunity

authors： Reddy S,Wu D,Poole CA

更新日期：1996-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown aetiology. Although it has been reported that T cells might be responsible for the pathogenesis of SLE, it remains unclear whether immune aberrations of SLE T cells are the primary event in this pathological process. We have recently report...

journal_title：Journal of autoimmunity

authors： Tsuzaka K,Takeuchi T,Onoda N,Pang M,Abe T

更新日期：1998-10-01 00:00:00

abstract：:The thymus of New Zealand black (NZB) mice undergoes premature involution. In addition, cultured thymic epithelial cells from NZB mice undergo accelerated preprogrammed degeneration. NZB mice also have distinctive and well-defined abnormalities of thymic architecture involving stromal cells, defined by staining with m...

journal_title：Journal of autoimmunity

authors： Takeoka Y,Taguchi N,Shultz L,Boyd RL,Naiki M,Ansari AA,Gershwin ME

更新日期：1999-11-01 00:00:00

abstract：:The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients ...

journal_title：Journal of autoimmunity

authors： Amador-Patarroyo MJ,Arbelaez JG,Mantilla RD,Rodriguez-Rodriguez A,Cárdenas-Roldán J,Pineda-Tamayo R,Guarin MR,Kleine LL,Rojas-Villarraga A,Anaya JM

更新日期：2012-09-01 00:00:00

abstract：:Tight-skin (TSK) mouse, the experimental model for scleroderma, develops cutaneous hyperplasia, cardiac hypertrophy, pulmonary emphysema and autoimmunity against scleroderma target autoantigens. The cutaneous hyperplasia is associated with the accumulation of microfibrils and elastic fibers in the middle and deep derm...

journal_title：Journal of autoimmunity

authors： Kasturi KN,Hatakeyama A,Murai C,Gordon R,Phelps RG,Bona CA

更新日期：1997-12-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characteristized by the presence of autoantibodies against double-stranded DNA (anti-dsDNA) in sera at high levels. Bacterial infections in SLE are associated with higher morbidity and mortality. Our goal was to observe the interaction between thes...

journal_title：Journal of autoimmunity

authors： Lee TP,Tang SJ,Wu MF,Song YC,Yu CL,Sun KH

更新日期：2010-12-01 00:00:00

abstract：:The great majority of insulin-specific T cell clones isolated from islets of NOD mice react with insulin peptide B-(9-23) (amino acids 9-23 of the insulin B chain). The T cell receptors of these clones contain diverse beta-chains but restricted alpha-chains. The dominant alpha-chain motif is a V alpha 13 segment (10 o...

journal_title：Journal of autoimmunity

authors： Simone EA,Yu L,Wegmann DR,Eisenbarth GS

更新日期：1997-06-01 00:00:00

abstract：:Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

journal_title：Journal of autoimmunity

authors： Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

更新日期：2004-06-01 00:00:00

abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

journal_title：Journal of autoimmunity

authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

更新日期：1999-09-01 00:00:00

abstract：:Clinical course and changes in serum levels of antibodies to the acetylcholine receptor (a-AChR) were followed in 82 patients with myasthenia gravis during a period of 1-8 years after thymectomy. Decrease in a-AChR immediately after thymectomy was influenced by changes in a total IgG. Immunosuppressive medication affe...

journal_title：Journal of autoimmunity

authors： Kuks JB,Oosterhuis HJ,Limburg PC,The TH

更新日期：1991-04-01 00:00:00

abstract：:Since its description in 1965, Sneddon syndrome (SNS) is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The presence of many other manifestations suggests that it is a systemic syndrome. The prevalence of anti-phospholipid antibodies (aPL) is highly...

journal_title：Journal of autoimmunity

authors： Francès C,Piette JC

更新日期：2000-09-01 00:00:00