T-cell reactivity in myasthenia gravis.

abstract：:Aberrant expression of the p21Ras proto-oncogene has been reported in lymphoid cells of SLE patients. We previously showed that the expression of the p21Ras stimulatory element, hSOS1, is reduced in PBMC from SLE patients with non-active disease. However, the significance of this finding regarding the regulation and f...

journal_title：Journal of autoimmunity

authors： Rapoport MJ,Amit M,Aharoni D,Weiss M,Weissgarten J,Bruck N,Buchs A,Bistritzer T,Molad Y

更新日期：2002-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune diseases. In both human and mouse SLE diseases, the autoimmune response targets a restricted set of autoantigens. Many of them are nucleic acids and proteins involved in the synthesis and processing of DNA or RNA, a characteristic which should ...

journal_title：Journal of autoimmunity

authors： Gilbert D,Brard F,Jovelin F,Tron F

更新日期：1996-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

journal_title：Journal of autoimmunity

authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

更新日期：2012-05-01 00:00:00

abstract：:Previous studies have demonstrated increased expression of a laminin-like protein in labial salivary glands from Sjögren's syndrome (SS) patients. The objective of the present study was to verify the identity of this protein and to compare lymphocytic infiltration and laminin expression in minor salivary gland ductal ...

journal_title：Journal of autoimmunity

authors： McArthur CP,Daniels PJ,Kragel P,Howard PF,Julian L

更新日期：1997-02-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contri...

journal_title：Journal of autoimmunity

authors： François A,Gombault A,Villeret B,Alsaleh G,Fanny M,Gasse P,Adam SM,Crestani B,Sibilia J,Schneider P,Bahram S,Quesniaux V,Ryffel B,Wachsmann D,Gottenberg JE,Couillin I

更新日期：2015-01-01 00:00:00

abstract：:Susceptibility to Pemphigus, an autoimmune disease of the skin, has been previously linked to DRB1*0402, 1401/04 and DQB1*0503 in pemphigus vulgaris (PV), to DRB1*0102, 0404, 1402/06 in endemic pemphigus foliaceus in Brazil and to DRB1*04 in Italian patients suffering from pemphigus foliaceus (PF). The disease is caus...

journal_title：Journal of autoimmunity

authors： Loiseau P,Lecleach L,Prost C,Lepage V,Busson M,Bastuji-Garin S,Roujeau JC,Charron D

更新日期：2000-08-01 00:00:00

abstract：:We have investigated the pathophysiological basis of cardiac dysfunction in autoimmune myocarditis and in the resulting dilated cardiomyopathy. To this end we utilized the myosin-induced autoimmune myocarditis model in BALB/c mice. Myocarditis has been found to be associated with massive ventricular lymphocyte infiltr...

journal_title：Journal of autoimmunity

authors： Less H,Shilkrut M,Rubinstein I,Berke G,Binah O

更新日期：1999-05-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

journal_title：Journal of autoimmunity

authors： Reddy S,Wu D,Poole CA

更新日期：1996-02-01 00:00:00

abstract：:Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

journal_title：Journal of autoimmunity

authors： Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

更新日期：2007-06-01 00:00:00

abstract：:GAD65 (glutamic acid decarboxylase) is an important autoantigen in both type 1 (insulin-dependent) diabetes mellitus (IDDM) and the neurological autoimmune disease stiff-man syndrome (SMS), and is expressed in pancreatic islets as well as the nervous system. Still, only 30% of SMS patients also have type 1 diabetes. T...

journal_title：Journal of autoimmunity

authors： Schloot NC,Batstra MC,Duinkerken G,De Vries RR,Dyrberg T,Chaudhuri A,Behan PO,Roep BO

更新日期：1999-06-01 00:00:00

abstract：:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...

journal_title：Journal of autoimmunity

authors： Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Gut dysbiosis has been reported implicated in ankylosing spondylitis (AS), a common chronic inflammatory disease mainly affects sacroiliac joints and spine. Utilizing deep sequencing on the feces of untreated AS patients, our study aimed at providing an in-depth understanding of AS gut microbiota. METHODS:We...

journal_title：Journal of autoimmunity

authors： Zhou C,Zhao H,Xiao XY,Chen BD,Guo RJ,Wang Q,Chen H,Zhao LD,Zhang CC,Jiao YH,Ju YM,Yang HX,Fei YY,Wang L,Shen M,Li H,Wang XH,Lu X,Yang B,Liu JJ,Li J,Peng LY,Zheng WJ,Zhang CY,Zhou JX,Wu QJ,Yang YJ,Su

更新日期：2020-02-01 00:00:00

abstract：:Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

journal_title：Journal of autoimmunity

authors： Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

更新日期：2013-03-01 00:00:00

abstract：:Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in ...

journal_title：Journal of autoimmunity

authors： Badami E,Maiuri L,Quaratino S

更新日期：2005-03-01 00:00:00

abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

journal_title：Journal of autoimmunity

authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

更新日期：1995-10-01 00:00:00

abstract：:There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

journal_title：Journal of autoimmunity

authors： Miller JF

更新日期：1992-04-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

journal_title：Journal of autoimmunity

authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:The complement component C4 is encoded by two genes: C4A and C4B on human chromosome 6p in the major histocompatibility complex (MHC). Most studies have linked the deficiencies in C4 with systemic lupus erythematosus (SLE) in Angio-Irish, North American, Black American, Mexican American, Australian and Japanese popula...

journal_title：Journal of autoimmunity

authors： Ittiprasert W,Kantachuvesiri S,Pavasuthipaisit K,Verasertniyom O,Chaomthum L,Totemchokchyakarn K,Kitiyanant Y

更新日期：2005-08-01 00:00:00

abstract：:Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

journal_title：Journal of autoimmunity

authors： Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

更新日期：2000-02-01 00:00:00

abstract：:There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway. ...

journal_title：Journal of autoimmunity

authors： Michaelson JS,Wisniacki N,Burkly LC,Putterman C

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

journal_title：Journal of autoimmunity

authors： Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

更新日期：2019-07-01 00:00:00

abstract：:In 1990 our group reported a patient with autoimmune hemolytic anemia and high titers of IgM anticardiolipin antibodies that cross-reacted with phosphatidylcholine (PTC). These autoantibodies also recognized bromelain-treated erythrocytes (BrE) and in vitro aged erythrocytes. The epitope exposed with this treatment is...

journal_title：Journal of autoimmunity

authors： Cabiedes J,Cabral AR,López-Mendoza AT,Cordero-Esperón HA,Huerta MT,Alarcón-Segovia D

更新日期：2002-03-01 00:00:00

abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

journal_title：Journal of autoimmunity

authors： Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

更新日期：2002-11-01 00:00:00

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

journal_title：Journal of autoimmunity

authors： Fava A,Petri M

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to characterize regulatory T cells (T(reg)) in skin lesions and peripheral blood from patients with dermatomyositis (DM) and to determine the serum levels of regulatory cytokines in the disease. In skin biopsy specimens from patients with DM, immunohistochemistry was performed for CD4(+),...

journal_title：Journal of autoimmunity

authors： Antiga E,Kretz CC,Klembt R,Massi D,Ruland V,Stumpf C,Baroni G,Hartmann M,Hartschuh W,Volpi W,Del Bianco E,Enk A,Fabbri P,Krammer PH,Caproni M,Kuhn A

更新日期：2010-12-01 00:00:00

abstract：:Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

journal_title：Journal of autoimmunity

authors： Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

更新日期：2014-05-01 00:00:00

abstract：:There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

journal_title：Journal of autoimmunity

authors： Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

更新日期：1992-04-01 00:00:00

abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

journal_title：Journal of autoimmunity

authors： Bonam SR,Wang F,Muller S

更新日期：2018-11-01 00:00:00