Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

journal_title：Journal of autoimmunity

authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

更新日期：2018-12-01 00:00:00

abstract：:Isolated congenital heart block may be associated with autoimmune disorder such as Sjögren Syndrome and systemic lupus erythematosus. In this work we demonstrate circulating autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor (mAChR) in the sera of children with congenital heart block. This anti...

journal_title：Journal of autoimmunity

authors： Borda E,Sterin-Borda L

更新日期：2001-03-01 00:00:00

abstract：:HLA-DQB1 is widely considered to be the major histocompatibility complex (MHC) susceptibility gene for type 1 diabetes (T1D). However, since inheritance of the gene in T1D is recessive, the presence of the protective HLA-DQB1 0602 allele with normal nucleotide sequence in some patients raises the question of whether H...

journal_title：Journal of autoimmunity

authors： Husain Z,Kelly MA,Eisenbarth GS,Pugliese A,Awdeh ZL,Larsen CE,Alper CA

更新日期：2008-06-01 00:00:00

abstract：:Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

journal_title：Journal of autoimmunity

authors： Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

更新日期：2015-02-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:Eight patients with arthritis (seven with rheumatoid, one with psoriatic arthritis) were treated for 7 d with a daily injection of 10 mg of mouse monoclonal anti-CD4 antibodies (three with VIT4, five with MT151). With the exception of a short-lasting low-grade fever in one patient, no side effects were observed. Clini...

journal_title：Journal of autoimmunity

authors： Herzog C,Walker C,Müller W,Rieber P,Reiter C,Riethmüller G,Wassmer P,Stockinger H,Madic O,Pichler WJ

更新日期：1989-10-01 00:00:00

abstract：:The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

journal_title：Journal of autoimmunity

authors： Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

更新日期：1998-08-01 00:00:00

abstract：:IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

journal_title：Journal of autoimmunity

authors： Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

更新日期：1996-06-01 00:00:00

abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

journal_title：Journal of autoimmunity

authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

更新日期：2019-01-01 00:00:00

abstract：:Peptidyl arginine deiminases (PADs) catalyze a post-translational protein modification reaction called citrullination, where arginine is converted to citrulline. This modification has been linked to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). More recently, several studies have suggest...

journal_title：Journal of autoimmunity

authors： Acharya NK,Nagele EP,Han M,Coretti NJ,DeMarshall C,Kosciuk MC,Boulos PA,Nagele RG

更新日期：2012-06-01 00:00:00

abstract：:To study the potential roles of cytokines in development and resolution of granulomatous experimental autoimmune thyroiditis (EAT), the kinetics of in vivo expression of cytokine genes in thyroid infiltrates was analysed using reverse transcriptase-PCR (RT-PCR). Both Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) c...

journal_title：Journal of autoimmunity

authors： Tang H,Sharp GC,Chen K,Braley-Mullen H

更新日期：1998-12-01 00:00:00

abstract：:The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

journal_title：Journal of autoimmunity

authors： Bearzatto M,Lampasona V,Belloni C,Bonifacio E

更新日期：2003-12-01 00:00:00

abstract：:There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

journal_title：Journal of autoimmunity

authors： Miller JF

更新日期：1992-04-01 00:00:00

abstract：:Aberrant expression of the p21Ras proto-oncogene has been reported in lymphoid cells of SLE patients. We previously showed that the expression of the p21Ras stimulatory element, hSOS1, is reduced in PBMC from SLE patients with non-active disease. However, the significance of this finding regarding the regulation and f...

journal_title：Journal of autoimmunity

authors： Rapoport MJ,Amit M,Aharoni D,Weiss M,Weissgarten J,Bruck N,Buchs A,Bistritzer T,Molad Y

更新日期：2002-08-01 00:00:00

abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

journal_title：Journal of autoimmunity

authors： Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

更新日期：2002-11-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

journal_title：Journal of autoimmunity

authors： Chiaroni-Clarke RC,Munro JE,Ellis JA

更新日期：2016-05-01 00:00:00

abstract：:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addi...

journal_title：Journal of autoimmunity

authors： Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

更新日期：1992-08-01 00:00:00

abstract：:(Beta2-glycoprotein I (beta2GPI) is a plasma protein that plays an important role in the antigenic specificity of antiphospholipid autoantibodies (aPL). These antibodies are associated with an increased risk for thrombosis and recurrent foetal loss in humans. Crystallographic analysis of beta2GPI showed that its five ...

journal_title：Journal of autoimmunity

authors： Iverson GM,Matsuura E,Victoria EJ,Cockerill KA,Linnik MD

更新日期：2002-06-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) can progress to cytokine storm that is associated with organ dysfunction and death. The purpose of the present study is to determine clinical characteristics associated with 28 day in-hospital survival in patients with coronavirus disease 2019 (COVID-19) that received tocilizumab. T...

journal_title：Journal of autoimmunity

authors： Morrison AR,Johnson JM,Griebe KM,Jones MC,Stine JJ,Hencken LN,To L,Bianchini ML,Vahia AT,Swiderek J,Ramesh MS,Peters MA,Smith ZR

更新日期：2020-11-01 00:00:00

abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

journal_title：Journal of autoimmunity

authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

更新日期：2005-09-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

journal_title：Journal of autoimmunity

authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

更新日期：2020-03-01 00:00:00

abstract：:Lupus erythematosus (LE) is an inflammatory connective tissue disease of generalized autoimmunity characterized by pathogenic autoantibodies and immune complexes, attributed to loss of immune tolerance. Cutaneous involvement, which appears in the majority of patients with the disease, can present as LE-specific or LE-...

journal_title：Journal of autoimmunity

authors： Kuhn A,Landmann A

更新日期：2014-02-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction, and the secretion of TNF-alpha or IFN-gamma. The secretion of IFN-gamma can contribute to b...

journal_title：Journal of autoimmunity

authors： Barral AM,Thomas HE,Ling EM,Darwiche R,Rodrigo E,Christen U,Ejrnaes M,Wolfe T,Kay TW,von Herrath MG

更新日期：2006-11-01 00:00:00

abstract：:The purpose of this study was to characterize regulatory T cells (T(reg)) in skin lesions and peripheral blood from patients with dermatomyositis (DM) and to determine the serum levels of regulatory cytokines in the disease. In skin biopsy specimens from patients with DM, immunohistochemistry was performed for CD4(+),...

journal_title：Journal of autoimmunity

authors： Antiga E,Kretz CC,Klembt R,Massi D,Ruland V,Stumpf C,Baroni G,Hartmann M,Hartschuh W,Volpi W,Del Bianco E,Enk A,Fabbri P,Krammer PH,Caproni M,Kuhn A

更新日期：2010-12-01 00:00:00

abstract：:In 1990 our group reported a patient with autoimmune hemolytic anemia and high titers of IgM anticardiolipin antibodies that cross-reacted with phosphatidylcholine (PTC). These autoantibodies also recognized bromelain-treated erythrocytes (BrE) and in vitro aged erythrocytes. The epitope exposed with this treatment is...

journal_title：Journal of autoimmunity

authors： Cabiedes J,Cabral AR,López-Mendoza AT,Cordero-Esperón HA,Huerta MT,Alarcón-Segovia D

更新日期：2002-03-01 00:00:00

abstract：:Wegener's autoantigen (WA), a 29 kD multifunctional protein, is the principal target antigen of autoantibodies associated with Wegener's granulomatosis (WG). WA was first identified as proteinase 3 (PR3), which is now known to be identical with myeloblastin and AGP7. Like other lysosomal proteins, WA/PR3 displays enzy...

journal_title：Journal of autoimmunity

authors： Gross WL,Csernok E,Flesch BK

更新日期：1993-04-01 00:00:00

abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

journal_title：Journal of autoimmunity

authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

更新日期：2002-12-01 00:00:00

abstract：:Epitopes with linear sequences recognized by anti-La autoantibodies from seven mothers of children with congenital heart block were recently defined. Eight of these epitopes share sequence identity with three other proteins in addition to the original autoantigen, La. The three proteins are human cardiac myosin beta h...

journal_title：Journal of autoimmunity

authors： Horsfall AC,Rose LM

更新日期：1992-08-01 00:00:00