当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype.

Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype.

Abstract：

:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addition to being an anti-DNA antibody, also binds to MMTV glycoproteins. Following immunization into the footpad of naive BALB/c mice with MIV-7, the mice developed anti-phospholipid syndrome (APLS) and SLE. The APLS was characterized by thrombocytopenia, the presence of anticardiolipin antibodies, lupus anticoagulant (prolonged APTT), high resorption rate of fetuses and lower mean weights of the placentae and fetuses. The SLE was characterized by serological markers (e.g. anti-DNA), laboratory (increased sedimentation rate and proteinuria) and histological findings (deposition of immune complexes in the glomeruli). Active immunization of mice with mouse monoclonal anti-cardiolipin antibodies led to the induction of primary APLS without SLE. The results add to our previous passive transfer model in which mouse monoclonal anti-cardiolipin antibody generated from immunized mice (CAM) was infused into the tail vein and also resulted in induction of pure APLS [11]. Our results demonstrate the ability to induce secondary APLS to SLE following immunization with a pathogenic idiotype of anti-DNA antibodies and to induce primary APLS with anti-cardiolipin mAb. The existence of these experimental models may permit controlled studies of novel therapeutic models.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

doi

10.1016/0896-8411(92)90008-e

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

495-509

issue

4

eissn

0896-8411

issn

1095-9157

pii

0896-8411(92)90008-E

journal_volume

5

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

    abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.02.004

    authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

    更新日期：2012-06-01 00:00:00

  • A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production.

    abstract：:A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recogniti...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80048-4

    authors： Stiemer RH,Westenfelder U,Gausepohl H,Mirshahi M,Gundt A,Frank RW,Männel DN

    更新日期：1992-02-01 00:00:00

  • Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.

    abstract：:Experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), is dependent upon the activation and effector functions of autoreactive CD4 T cells. Multiple interactions between CD4 T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) must occu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.10.006

    authors： Wu GF,Shindler KS,Allenspach EJ,Stephen TL,Thomas HL,Mikesell RJ,Cross AH,Laufer TM

    更新日期：2011-02-01 00:00:00

  • Limiting dilution analysis of Epstein-Barr virus infectable B cells secreting anti-Ro/SSA and anti-La/SSB antibodies in neonatal lupus erythematosus and systemic lupus erythematosus.

    abstract：:Neonatal lupus erythematosus (NLE) is associated with the transplacental passage of maternal anti-Ro and anti-La antibodies. In order to better determine the risk of delivery of a child with NLE, we examined the frequency of anti-Ro and anti-La antibody secreting cells in mothers of children with NLE and in mothers at...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1993.1040

    authors： Isacovics B,Silverman ED

    更新日期：1993-08-01 00:00:00

  • Thermolabile and calcium-dependent serum factor interferes with polymerized actin, and impairs anti-actin antibody detection.

    abstract：:The detection of anti-actin (AAA) by immunofluorescence is hindered by the presence of a serum factor. To better understand how it interferes with AAA detection, we tested sera from 20 patients with autoimmune hepatitis, and from 21 healthy adults, diluted 1:10 and prepared as follows: (A) diluted with PBS; (B) inacti...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0540

    authors： Cançado EL,Abrantes-Lemos CP,Vilas-Boas LS,Novo NF,Carrilho FJ,Laudanna AA

    更新日期：2001-11-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.

    abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1995.0047

    authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

    更新日期：1995-10-01 00:00:00

  • Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation.

    abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an increasingly widely used treatment modality in hematological malignancies. Alloreactivity mediated by donor T cells (and, in some settings, by donor natural killer cells) can produce durable immunologic control or eradication of residual malignancy after alloge...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.002

    authors： Rezvani AR,Storb RF

    更新日期：2008-05-01 00:00:00

  • Sex differences and genomics in autoimmune diseases.

    abstract：:Autoimmune diseases (AIDs) are believed to be multifactorial diseases that commonly involve multiple organ systems. About three fourth of the patients afflicted with AIDs are women suggesting that sex differences impact the incidence of AID. However, the proportion of females to males suffering from AID varies dependi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2011.12.001

    authors： Amur S,Parekh A,Mummaneni P

    更新日期：2012-05-01 00:00:00

  • Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor-α agents in rheumatic diseases; A systematic review and meta-analysis.

    abstract：OBJECTIVE:To evaluate the efficacy and safety of biosimilars of anti-tumor necrosis factor (TNF)-α agents compared to their reference agents in immune mediated diseases. METHODS:Electronic databases were searched for randomized controlled trials (RCTs) assessing the efficacy and safety of biosimilars of anti-TNF-α age...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaut.2017.02.003

    authors： Komaki Y,Yamada A,Komaki F,Kudaravalli P,Micic D,Ido A,Sakuraba A

    更新日期：2017-05-01 00:00:00

  • Induction of lupus autoantibodies by adjuvants.

    abstract：:Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven groups of 3-month-old female BALB/cJ mice received a single intraperi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(03)00083-0

    authors： Satoh M,Kuroda Y,Yoshida H,Behney KM,Mizutani A,Akaogi J,Nacionales DC,Lorenson TD,Rosenbauer RJ,Reeves WH

    更新日期：2003-08-01 00:00:00

  • Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: the significance of the intra-bone marrow injection.

    abstract：:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.004

    authors： Sonoda Y

    更新日期：2008-05-01 00:00:00

  • Monoclonal anti-La antibody derived from a mouse with experimental SLE is similar to human anti-La antibodies.

    abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80037-x

    authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

    更新日期：1990-12-01 00:00:00

  • Autoimmunity to the glutamate receptor in mice--a model for Rasmussen's encephalitis?

    abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0297

    authors： Levite M,Hermelin A

    更新日期：1999-08-01 00:00:00

  • Differences between normal and autoimmune T cell responses to autologous erythrocytes and haemoglobin: impairment of haptoglobin-mediated inhibition in NZB spleen cells.

    abstract：:Helper T cells are required for development of the autoantibody responses to native mouse erythrocytes (MRBC) that spontaneously develop in NZB mice. However, the stimulus for these Th is not known. Therefore, we compared the abilities of splenic T cells from actively autoimmune old NZB mice and preautoimmune, young N...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0062

    authors： Calkins CE,Esposito M

    更新日期：1996-08-01 00:00:00

  • The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.

    abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disorder that is characterized by dysfunction and destruction of the exocrine glands. Exocrinopathy is associated with periductal mononuclear cell infiltrates in the affected exocrine glands and B-cell hyperreactivity. Epithelial cells are thought to play an important pa...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2010.06.011

    authors： Manoussakis MN,Kapsogeorgou EK

    更新日期：2010-11-01 00:00:00

  • Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease.

    abstract：:Peptidyl arginine deiminases (PADs) catalyze a post-translational protein modification reaction called citrullination, where arginine is converted to citrulline. This modification has been linked to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). More recently, several studies have suggest...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.03.004

    authors： Acharya NK,Nagele EP,Han M,Coretti NJ,DeMarshall C,Kosciuk MC,Boulos PA,Nagele RG

    更新日期：2012-06-01 00:00:00

  • The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.

    abstract：:The Diffuse Infiltrative Lymphocytosis Syndrome (DILS) is a rare multisystemic syndrome described in HIV-infected patients. It is characterised by CD8(+) T-cell lymphocytosis associated with a CD8(+) T-cell infiltration of multiple organs. DILS is usually seen in uncontrolled or untreated HIV infection but can also ma...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2015.01.010

    authors： Ghrenassia E,Martis N,Boyer J,Burel-Vandenbos F,Mekinian A,Coppo P

    更新日期：2015-05-01 00:00:00

  • Cell and gene therapy using mesenchymal stem cells (MSCs).

    abstract：:Mesenchymal stem cells (MSCs) are considered to be a promising platform for cell and gene therapy for a variety of diseases. First, in the field of hematopoietic stem cell transplantation, there are two applications of MSCs: 1) the improvement of stem cell engrafting and the acceleration of hematopoietic reconstitutio...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.008

    authors： Ozawa K,Sato K,Oh I,Ozaki K,Uchibori R,Obara Y,Kikuchi Y,Ito T,Okada T,Urabe M,Mizukami H,Kume A

    更新日期：2008-05-01 00:00:00

  • Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjögren's syndrome.

    abstract：BACKGROUND/PURPOSE:Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily involving the exocrine glands. The clinical picture of SS ranges from exocrinopathy to systemic disease affecting the lung, kidney, liver, skin, musculockeletal and nervous systems. The morbidity of SS is mainly determined by e...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.05.018

    authors： Agmon-Levin N,Kivity S,Tzioufas AG,López Hoyos M,Rozman B,Efes I,Shapira Y,Shamis A,Amital H,Youinou P,Shoenfeld Y

    更新日期：2012-09-01 00:00:00

  • Structural characterization of an (NZB x NZW)F1 mouse-derived IgM monoclonal antibody that binds through V region-dependent interactions to murine IgG anti-DNA antibodies.

    abstract：:Among B/W-derived IgM mAb, 12.5H was selected because of its ability to recognize, in solid phase ELISAs, IgG mAb with DNA-binding activity. mAb 12.5H bound preferentially to IgG2a mAb and did not react with B/W- or BALB/c-derived IgG2a mAb with no DNA-binding activity, suggesting V region-mediated interactions. mAb 1...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1056

    authors： Margaritte C,Gilbert D,Brard F,Tron F

    更新日期：1994-12-01 00:00:00

  • Treatment with antibody reactive with the nephritogenic idiotype, IdLNF1, suppresses its production and leads to prolonged survival of (NZB x SWR)F1 mice.

    abstract：:The F1 progeny of the cross between SWR and NZB mice (SNF1) develop severe immune complex glomerulonephritis, similar to that seen in human SLE. An idiotypically-related family of nephritic antibodies (IdLNF1) has been shown to be important in the pathogenesis of autoimmune glomerulonephritis in these mice. Interestin...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1003

    authors： Uner AH,Knupp CJ,Tatum AH,Gavalchin J

    更新日期：1994-02-01 00:00:00

  • Acquisition of autoimmunity genes by New Zealand mice is associated with natural resistance to infection by mycobacteria.

    abstract：:New Zealand (NZ) mouse strains comprise both autoimmune and non-autoimmune animals: NZ black (NZB) mice and the F1 hybrid (NZB/W) of NZB and NZ white (NZW) mice show spontaneous autoimmune disease by 6 months of age and die before the first year of age from renal disease, while NZW mice do not show autoimmune disorder...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(92)90160-r

    authors： Esaguy N,Macedo PM,Castro AP,Aguas AP

    更新日期：1992-10-01 00:00:00

  • Targeting CD6 for the treatment of experimental autoimmune uveitis.

    abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2018.02.004

    authors： Zhang L,Li Y,Qiu W,Bell BA,Dvorina N,Baldwin WM 3rd,Singer N,Kern T,Caspi RR,Fox DA,Lin F

    更新日期：2018-06-01 00:00:00

  • PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis.

    abstract：:A dual isotype (IgG, IgA) enzyme-linked immunosorbent assay (ELISA) designed to provide enhanced detection of primary biliary cirrhosis (PBC)-specific autoantibodies against both major mitochondrial and nuclear antigens has been developed and recently become commercially available. The assay (PBC Screen) simultaneousl...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.09.005

    authors： Liu H,Norman GL,Shums Z,Worman HJ,Krawitt EL,Bizzaro N,Vergani D,Bogdanos DP,Dalekos GN,Milkiewicz P,Czaja AJ,Heathcote EJ,Hirschfield GM,Tan EM,Miyachi K,Bignotto M,Battezzati PM,Lleo A,Leung PS,Podda M,Gershwin

    更新日期：2010-12-01 00:00:00

  • Accessibility of epitopes on the 52-kD Ro/SSA protein (Ro52) and on the RoRNP associated Ro52 protein as determined by anti-peptide antibodies.

    abstract：:The Ro ribonucleoprotein particle (RoRNP) is the target of a variety of specific anti-protein autoantibodies produced by patients with systemic autoimmune diseases. RoRNPs, the function of which remains elusive, appear to be rather heterogeneous in terms of their molecular composition. Among several Ro proteins, a pro...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0122

    authors： Ricchiuti V,Pruijn GJ,Thijssen JP,van Venrooij WJ,Muller S

    更新日期：1997-04-01 00:00:00

  • Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with systemic lupus erythematosus by direct or indirect mechanisms.

    abstract：:A subgroup of murine monoclonal anti-DNA antibodies bind to vascular endothelial cells either directly as a result of cross-reactivity, or indirectly through immunoglobulin-bound DNA and DNA-binding proteins on the endothelial cell membrane. To determine whether these mechanisms apply in human systemic lupus erythemat...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.9998

    authors： Chan TM,Cheng IK

    更新日期：1997-10-01 00:00:00

  • T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice.

    abstract：:The great majority of insulin-specific T cell clones isolated from islets of NOD mice react with insulin peptide B-(9-23) (amino acids 9-23 of the insulin B chain). The T cell receptors of these clones contain diverse beta-chains but restricted alpha-chains. The dominant alpha-chain motif is a V alpha 13 segment (10 o...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0134

    authors： Simone EA,Yu L,Wegmann DR,Eisenbarth GS

    更新日期：1997-06-01 00:00:00

  • Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma.

    abstract：:Immunostimulatory CpG motifs can preferentially induce Th1 immune responses and have been applied to treat Th2-dominant disease. In this study, we investigated whether a plasmid with the addition of 20 copies of an immunostimulatory CpG motif (pB-CpG20) might prevent the development of scleroderma-like syndrome in tig...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2005.01.014

    authors： Shen Y,Ichino M,Nakazawa M,Ikejima T,Kojima Y,Okuda K,Minami M

    更新日期：2005-05-01 00:00:00

  • Autoimmunity: from black water fever to regulatory function.

    abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

    journal_title：Journal of autoimmunity

    pub_type： 社论,历史文章

    doi：10.1016/j.jaut.2013.12.019

    authors： Chang C

    更新日期：2014-02-01 00:00:00

  • Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus.

    abstract：:Previous studies have indicated that blood mononuclear cells from 15-20% of patients with systemic lupus erythematosus (SLE) carry elevated levels of hsp90, a heat shock protein associated with steroid receptors in cells. We analysed surface expression of hsp90 on mononuclear cells (lymphocytes and monocytes) from pat...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(92)90194-u

    authors： Erkeller-Yüksel FM,Isenberg DA,Dhillon VB,Latchman DS,Lydyard PM

    更新日期：1992-12-01 00:00:00