Monoclonal anti-La antibody derived from a mouse with experimental SLE is similar to human anti-La antibodies.

abstract：:Wegener's autoantigen (WA), a 29 kD multifunctional protein, is the principal target antigen of autoantibodies associated with Wegener's granulomatosis (WG). WA was first identified as proteinase 3 (PR3), which is now known to be identical with myeloblastin and AGP7. Like other lysosomal proteins, WA/PR3 displays enzy...

journal_title：Journal of autoimmunity

authors： Gross WL,Csernok E,Flesch BK

更新日期：1993-04-01 00:00:00

abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

journal_title：Journal of autoimmunity

authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

更新日期：2020-08-01 00:00:00

abstract：:Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

journal_title：Journal of autoimmunity

authors： Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

更新日期：2007-06-01 00:00:00

abstract：:Murine monoclonal antibodies (mAb) reacting with affinity-purified antihistone antibodies (AHA) from serum of a patient with systemic lupus erythematosus (SLE) were obtained. One of them, 8B3, was initially considered to recognize idiotypic (Id) determinants in AHA since (a) it reacted with AHA but not with control Ig...

journal_title：Journal of autoimmunity

authors： Subiza JL,Caturla A,Pereira LF,Camargo MC,Bustos A,Boimorto R,de la Concha EG

更新日期：1992-06-01 00:00:00

abstract：:In a proliferation assay, peripheral blood lymphocytes (PBL) from a relatively small proportion of myasthenia gravis (MG) patients and from controls responded to Torpedo acetylcholine receptor (T-AChR), which shows approximately 75% homology with the human AChR. Over 50% of MG patients responded to recombinant human A...

journal_title：Journal of autoimmunity

authors： Newsom-Davis J,Harcourt G,Sommer N,Beeson D,Willcox N,Rothbard JB

更新日期：1989-06-01 00:00:00

abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

journal_title：Journal of autoimmunity

authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

更新日期：2002-12-01 00:00:00

abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

journal_title：Journal of autoimmunity

authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

更新日期：2019-01-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

journal_title：Journal of autoimmunity

authors： Rimassa L,Personeni N,Aghemo A,Lleo A

更新日期：2019-06-01 00:00:00

abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

journal_title：Journal of autoimmunity

authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

更新日期：2006-11-01 00:00:00

abstract：:A recent report identified two islet cell cytoplasmic antibody subclasses using an immunohistochemical method. The islet cell cytoplasmic antibody subclass which reacts with only Beta-cells was termed 'Beta-cell islet cell cytoplasmic antibodies' and another islet cell cytoplasmic antibody subclass which reacts with B...

journal_title：Journal of autoimmunity

authors： Takino H,Kawasaki E,Yano M,Matsumoto K,Uotani S,Okuno S,Takao Y,Yamasaki H,Yamaguchi Y,Akazawa S

更新日期：1994-06-01 00:00:00

abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

journal_title：Journal of autoimmunity

authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

更新日期：2009-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

journal_title：Journal of autoimmunity

authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

更新日期：2013-03-01 00:00:00

abstract：:Approximately 25% of mature T cells possess two distinct cytoplasmic T cell receptor (TCR) alpha-chains, due to productive gene rearrangements of both alleles. Expression of two different alpha-chains at the cell surface is a potential risk factor for development of autoimmunity. However, it has been difficult to dete...

journal_title：Journal of autoimmunity

authors： Corthay A,Nandakumar KS,Holmdahl R

更新日期：2001-06-01 00:00:00

abstract：:Among B/W-derived IgM mAb, 12.5H was selected because of its ability to recognize, in solid phase ELISAs, IgG mAb with DNA-binding activity. mAb 12.5H bound preferentially to IgG2a mAb and did not react with B/W- or BALB/c-derived IgG2a mAb with no DNA-binding activity, suggesting V region-mediated interactions. mAb 1...

journal_title：Journal of autoimmunity

authors： Margaritte C,Gilbert D,Brard F,Tron F

更新日期：1994-12-01 00:00:00

abstract：:A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this pre...

journal_title：Journal of autoimmunity

authors： Quintero OL,Amador-Patarroyo MJ,Montoya-Ortiz G,Rojas-Villarraga A,Anaya JM

更新日期：2012-05-01 00:00:00

abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

journal_title：Journal of autoimmunity

authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

更新日期：2020-03-01 00:00:00

abstract：:In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

journal_title：Journal of autoimmunity

authors： Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

更新日期：2000-03-01 00:00:00

abstract：:In 1990 our group reported a patient with autoimmune hemolytic anemia and high titers of IgM anticardiolipin antibodies that cross-reacted with phosphatidylcholine (PTC). These autoantibodies also recognized bromelain-treated erythrocytes (BrE) and in vitro aged erythrocytes. The epitope exposed with this treatment is...

journal_title：Journal of autoimmunity

authors： Cabiedes J,Cabral AR,López-Mendoza AT,Cordero-Esperón HA,Huerta MT,Alarcón-Segovia D

更新日期：2002-03-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune rheumatic disease that targets salivary and lachrymal glands, characterized by a high concentration of serum autoantibodies directed against nuclear and cytoplasmic antigens. It is known that autoantibodies can enter viable cells and this phenomenon has functional consequences ...

journal_title：Journal of autoimmunity

authors： Sisto M,Lisi S,Castellana D,Scagliusi P,D'Amore M,Caprio S,Scagliusi A,Acquafredda A,Panaro MA,Mitolo V

更新日期：2006-08-01 00:00:00

abstract：:Autoimmune diseases are characterized serologically by the presence of antibodies to specific autoantigens. Antibodies to the two antigens Ro/SSA and La/SSB are found in patients with primary (pSS) and secondary Sjögren's syndrome (sSS). To explore if differences in the fine specificity of these autoantibodies could b...

journal_title：Journal of autoimmunity

authors： Wahren M,Solomin L,Pettersson I,Isenberg D

更新日期：1996-08-01 00:00:00

abstract：:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against th...

journal_title：Journal of autoimmunity

authors： Mobini R,Staudt A,Felix SB,Baumann G,Wallukat G,Deinum J,Svensson H,Hjalmarson A,Fu M

更新日期：2003-06-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：:We have previously described an SLE-derived human hybridoma autoantibody, 9604, which binds to activated but not to resting platelets, inhibits platelet aggregation, and immunoprecipitates a surface-labelled poly-peptide of 32,000 molecular weight (MW) (p32). In the present study, using a murine monoclonal anti-p32 an...

journal_title：Journal of autoimmunity

authors： Xu H,Frojmovic MM,Wong T,Rauch J

更新日期：1995-02-01 00:00:00

abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

journal_title：Journal of autoimmunity

authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

更新日期：2004-06-01 00:00:00

abstract：:We have previously demonstrated, in the collagen-induced arthritis model (CIA), that repetitive injections of immature bone-marrow-derived dendritic cells (iDCs) induce the expansion of a population of CD4CD49b-expressing cells, and that their adoptive transfer results in protection against CIA in a prophylactic setti...

journal_title：Journal of autoimmunity

authors： Charbonnier LM,Han WG,Quentin J,Huizinga TW,Zwerina J,Toes RE,Jorgensen C,Louis-Plence P

更新日期：2010-06-01 00:00:00

abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

journal_title：Journal of autoimmunity

authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

更新日期：2014-05-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

journal_title：Journal of autoimmunity

authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

更新日期：2018-12-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...

journal_title：Journal of autoimmunity

authors： Voynova E,Lefebvre F,Qadri A,Muller S

更新日期：2020-03-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00