The heterogeneity of whole islet cell cytoplasmic antibodies evidenced by absorption test with glutamic acid decarboxylase.

abstract：:Our purpose was to evaluate the role of Epstein-Barr virus (EBV) in the production of antiperinuclear factor (APF), a rheumatoid arthritis (RA)-specific marker, and the autoimmunogenicity of 'perinuclear antigens' (PNA) found within the buccal mucosa epithelial cells used as a substrate in the APF assay. Fifty APF-pos...

journal_title：Journal of autoimmunity

authors： Buisson M,Berthelot JM,Le Goff P,Chastel C,Lamour A,Seigneurin JM,Youinou P

更新日期：1994-08-01 00:00:00

abstract：:Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

journal_title：Journal of autoimmunity

authors： Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

更新日期：2014-05-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), is dependent upon the activation and effector functions of autoreactive CD4 T cells. Multiple interactions between CD4 T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) must occu...

journal_title：Journal of autoimmunity

authors： Wu GF,Shindler KS,Allenspach EJ,Stephen TL,Thomas HL,Mikesell RJ,Cross AH,Laufer TM

更新日期：2011-02-01 00:00:00

abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

journal_title：Journal of autoimmunity

authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

更新日期：2006-08-01 00:00:00

abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

journal_title：Journal of autoimmunity

authors： Levite M,Hermelin A

更新日期：1999-08-01 00:00:00

abstract：:Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

journal_title：Journal of autoimmunity

authors： Chiaroni-Clarke RC,Munro JE,Ellis JA

更新日期：2016-05-01 00:00:00

abstract：:Sera from autoimmune patients and normal volunteers were tested for antibodies to the A1 core protein of heteronuclear ribonucleoprotein (hnRNP) particles by ELISA and Western blot assays. The A1 protein used in these studies was produced by recombinant DNA technology. Thirty-seven per cent of patients with systemic l...

journal_title：Journal of autoimmunity

authors： Jensen L,Kuff EL,Wilson SH,Steinberg AD,Klinman DM

更新日期：1988-02-01 00:00:00

abstract：:Sex hormones, including estrogens, influence the immune system in a complex manner, playing an important role in the pathophysiology of autoimmune diseases. Estrogen receptors can be found in almost all cells, including those of the adaptive and innate immune systems. Depending on the relative preponderance and stimul...

journal_title：Journal of autoimmunity

authors： Lateef A,Petri M

更新日期：2012-05-01 00:00:00

abstract：:Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the pathogenesis of lupu...

journal_title：Journal of autoimmunity

authors： Koelsch KA,Webb R,Jeffries M,Dozmorov MG,Frank MB,Guthridge JM,James JA,Wren JD,Sawalha AH

更新日期：2013-03-01 00:00:00

abstract：:There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway. ...

journal_title：Journal of autoimmunity

authors： Michaelson JS,Wisniacki N,Burkly LC,Putterman C

更新日期：2012-09-01 00:00:00

abstract：:The presence or absence of autoimmune disease is a qualitative outcome resulting from the combined influences of genetic, environmental and stochastic factors that interact in complex ways. Because of the nature of these interactions, the effects of risk factors that contribute to the aetiology of disease cannot be ad...

journal_title：Journal of autoimmunity

authors： Baxter AG

更新日期：2001-05-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction, and the secretion of TNF-alpha or IFN-gamma. The secretion of IFN-gamma can contribute to b...

journal_title：Journal of autoimmunity

authors： Barral AM,Thomas HE,Ling EM,Darwiche R,Rodrigo E,Christen U,Ejrnaes M,Wolfe T,Kay TW,von Herrath MG

更新日期：2006-11-01 00:00:00

abstract：:Nowadays there is compelling evidence for immunoregulation by T cells. Recently, we showed that so-called 'anergic' T cells are not functionally inert but can act as regulatory cells by actively suppressing other T cell responses. We now show that 'anergic' T cells mediate this suppressive effect via modulation of the...

journal_title：Journal of autoimmunity

authors： Taams LS,Boot EP,van Eden W,Wauben MH

更新日期：2000-06-01 00:00:00

abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

journal_title：Journal of autoimmunity

authors： Daikh DI,Wofsy D

更新日期：1999-03-01 00:00:00

abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

journal_title：Journal of autoimmunity

authors： Harbige J,Eichmann M,Peakman M

更新日期：2017-11-01 00:00:00

abstract：:Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell com...

journal_title：Journal of autoimmunity

authors： Brennan FM,Chantry D,Jackson AM,Maini RN,Feldmann M

更新日期：1989-06-01 00:00:00

abstract：:CD4(+) T cells specific for immunologic non-self determinants on self-IgG, idiotopes (Id), can be raised from cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS). To test if Id-specific CD4(+) T cells have the potential to destroy oligodendrocytes (ODCs), we analyzed their ability to induce ap...

journal_title：Journal of autoimmunity

authors： Hestvik AL,Skorstad G,Vartdal F,Holmøy T

更新日期：2009-03-01 00:00:00

abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

journal_title：Journal of autoimmunity

authors： Chang C

更新日期：2014-02-01 00:00:00

abstract：:The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

journal_title：Journal of autoimmunity

authors： Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

更新日期：1998-08-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

journal_title：Journal of autoimmunity

authors： Reddy S,Wu D,Poole CA

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

journal_title：Journal of autoimmunity

authors： Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

更新日期：2019-07-01 00:00:00

abstract：:Myasthenia gravis (MG) is a prototypical antibody-mediated disease characterized by muscle weakness and fatigability. Serum antibodies to the acetylcholine receptor and muscle-specific tyrosine kinase receptor (MuSK) are found in about 85% and 8% of patients respectively. We have previously shown that more than 70% of...

journal_title：Journal of autoimmunity

authors： Marino M,Maiuri MT,Di Sante G,Scuderi F,La Carpia F,Trakas N,Provenzano C,Zisimopoulou P,Ria F,Tzartos SJ,Evoli A,Bartoccioni E

更新日期：2014-08-01 00:00:00

abstract：:The detection of anti-actin (AAA) by immunofluorescence is hindered by the presence of a serum factor. To better understand how it interferes with AAA detection, we tested sera from 20 patients with autoimmune hepatitis, and from 21 healthy adults, diluted 1:10 and prepared as follows: (A) diluted with PBS; (B) inacti...

journal_title：Journal of autoimmunity

authors： Cançado EL,Abrantes-Lemos CP,Vilas-Boas LS,Novo NF,Carrilho FJ,Laudanna AA

更新日期：2001-11-01 00:00:00

abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

journal_title：Journal of autoimmunity

authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

更新日期：2005-09-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

journal_title：Journal of autoimmunity

authors： Gleicher N,Barad DH

更新日期：2007-02-01 00:00:00

abstract：:Autoinflammatory diseases (AUIDs) are a genetically heterogeneous group of rheumatic diseases characterized by episodic inflammation linked with dysregulated innate immune responses. In this review, we summarize the molecular mechanisms altered by disease-associated variants in several AUIDs, including NOD2-associated...

journal_title：Journal of autoimmunity

authors： Hua Y,Shen M,McDonald C,Yao Q

更新日期：2018-03-01 00:00:00

abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

journal_title：Journal of autoimmunity

authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

更新日期：2006-11-01 00:00:00

abstract：:The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) expression profiles were analysed in tissues with differing disease st...

journal_title：Journal of autoimmunity

authors： Clanchy FIL,Borghese F,Bystrom J,Balog A,Penn H,Hull DN,Wells GMA,Kiriakidis S,Taylor PC,Sacre SM,Williams LM,Stone TW,Mageed RA,Williams RO

更新日期：2021-01-22 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00