Modelling the effects of genetic and environmental factors on the risk of autoimmune disease.

abstract：:IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), ...

journal_title：Journal of autoimmunity

authors： Bennett ST,Wilson AJ,Cucca F,Nerup J,Pociot F,McKinney PA,Barnett AH,Bain SC,Todd JA

更新日期：1996-06-01 00:00:00

abstract：:The 72 kD heat shock protein (hsp 72) has been postulated to play a role in the development of autoimmune disease and has been shown to be overexpressed in the Graves' disease thyroid gland. The expression and modulation of the 72 kD heat shock protein were therefore studied in cultured human thyroid epithelial cells ...

journal_title：Journal of autoimmunity

authors： Sztankay A,Trieb K,Lucciarini P,Steiner E,Grubeck-Loebenstein B

更新日期：1994-04-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprote...

journal_title：Journal of autoimmunity

authors： de Groot G PG,Bouma B,Lutters BC,Simmelink MJ,Derksen RH,Gros P

更新日期：2000-09-01 00:00:00

abstract：:Aberrant expression of the p21Ras proto-oncogene has been reported in lymphoid cells of SLE patients. We previously showed that the expression of the p21Ras stimulatory element, hSOS1, is reduced in PBMC from SLE patients with non-active disease. However, the significance of this finding regarding the regulation and f...

journal_title：Journal of autoimmunity

authors： Rapoport MJ,Amit M,Aharoni D,Weiss M,Weissgarten J,Bruck N,Buchs A,Bistritzer T,Molad Y

更新日期：2002-08-01 00:00:00

abstract：:HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by whi...

journal_title：Journal of autoimmunity

authors： Behrens M,Trejo T,Luthra H,Griffiths M,David CS,Taneja V

更新日期：2010-08-01 00:00:00

abstract：:The Foxp3(+)CD4(+) regulatory T-cell (Treg)-deficient Scurfy (Sf) mice rapidly develop severe inflammation in the skin and lungs with expanded Th subsets bearing increased expression of various chemokine/chemoattractant/retention receptor genes (CRG). Nine different double mutants were generated to elucidate their rol...

journal_title：Journal of autoimmunity

authors： Sharma R,Sung SS,Gaskin F,Fu SM,Ju ST

更新日期：2012-06-01 00:00:00

abstract：:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain de...

journal_title：Journal of autoimmunity

authors： Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix H

更新日期：1991-04-01 00:00:00

abstract：:The Ro ribonucleoprotein particle (RoRNP) is the target of a variety of specific anti-protein autoantibodies produced by patients with systemic autoimmune diseases. RoRNPs, the function of which remains elusive, appear to be rather heterogeneous in terms of their molecular composition. Among several Ro proteins, a pro...

journal_title：Journal of autoimmunity

authors： Ricchiuti V,Pruijn GJ,Thijssen JP,van Venrooij WJ,Muller S

更新日期：1997-04-01 00:00:00

abstract：:The specific contributions of islet cell microenvironment during the development of autoimmune type 1 diabetes remain unclear. The aims of this study were to identify early immune-driven abnormalities in islets and pancreatic lymph nodes of NOD mice by cDNA arrays. We compared gene expression profiles of purified isle...

journal_title：Journal of autoimmunity

authors： Aspord C,Rome S,Thivolet C

更新日期：2004-08-01 00:00:00

abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

journal_title：Journal of autoimmunity

authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

更新日期：2001-12-01 00:00:00

abstract：:Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

journal_title：Journal of autoimmunity

authors： Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

更新日期：2014-05-01 00:00:00

abstract：:Genetic abnormalities predisposing to autoimmunity generally act in a cooperative manner affecting one or several mechanisms regulating immunological tolerance. In addition, many of these genetic abnormalities are also involved in the development of lymphoproliferative diseases. In the present study, we have determine...

journal_title：Journal of autoimmunity

authors： Santiuste I,Buelta L,Iglesias M,Genre F,Mazorra F,Izui S,Merino J,Merino R

更新日期：2010-12-01 00:00:00

abstract：:The obstetric management of women with antiphospholipid (aPL) syndrome remains controversial. Despite recent advances, the controversies have been fueled by our limited understanding of the multi-factorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. We have escaped from the na...

journal_title：Journal of autoimmunity

authors： Rai R

更新日期：2000-09-01 00:00:00

abstract：:Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. Based upon the sequential multistep model of lymphocyte adhesion to the end...

journal_title：Journal of autoimmunity

authors： Yang XD,Michie SA,Tisch R,Karin N,Steinman L,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

journal_title：Journal of autoimmunity

authors： Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

更新日期：2000-02-01 00:00:00

abstract：:Immune cell infiltration to the brain's territory was considered for decades to reflect a pathological process in which immune cells attack the central nervous system (CNS); such a process is observed in the inflammatory autoimmune disease, multiple sclerosis (MS). As neuroinflammatory processes within the CNS parench...

journal_title：Journal of autoimmunity

authors： Schwartz M,Baruch K

更新日期：2014-11-01 00:00:00

abstract：:We compared the classical immunofluorescence test (IFT) and counterimmunoelectrophoresis method (CIE) with the new immunoblotting technique (IBT) for the detection of antinuclear antibodies (ANA). Sera from 200 patients were tested in all three assays. Patients were classified as having either rheumatic disease includ...

journal_title：Journal of autoimmunity

authors： Westgeest AA,van den Brink HG,de Jong J,Swaak AJ,Smeenk RJ

更新日期：1988-04-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...

journal_title：Journal of autoimmunity

authors： Zhang L,Li Y,Qiu W,Bell BA,Dvorina N,Baldwin WM 3rd,Singer N,Kern T,Caspi RR,Fox DA,Lin F

更新日期：2018-06-01 00:00:00

abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now e...

journal_title：Journal of autoimmunity

authors： Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

更新日期：2014-02-01 00:00:00

abstract：:The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

journal_title：Journal of autoimmunity

authors： Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

更新日期：1991-12-01 00:00:00

abstract：:The complement component C4 is encoded by two genes: C4A and C4B on human chromosome 6p in the major histocompatibility complex (MHC). Most studies have linked the deficiencies in C4 with systemic lupus erythematosus (SLE) in Angio-Irish, North American, Black American, Mexican American, Australian and Japanese popula...

journal_title：Journal of autoimmunity

authors： Ittiprasert W,Kantachuvesiri S,Pavasuthipaisit K,Verasertniyom O,Chaomthum L,Totemchokchyakarn K,Kitiyanant Y

更新日期：2005-08-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) has been shown to exist as two isoforms with molecular weights of 65 kD (GAD65) and 67 kD (GAD67) in the central nervous system as well as in several non-neuronal tissues, including the pancreatic islets. Recently, this enzyme has been proposed as a key beta-cell autoantigen in insuli...

journal_title：Journal of autoimmunity

authors： Reddy S,Wu D,Poole CA

更新日期：1996-02-01 00:00:00

abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

journal_title：Journal of autoimmunity

authors： Daikh DI,Wofsy D

更新日期：1999-03-01 00:00:00

abstract：:Susceptibility to Pemphigus, an autoimmune disease of the skin, has been previously linked to DRB1*0402, 1401/04 and DQB1*0503 in pemphigus vulgaris (PV), to DRB1*0102, 0404, 1402/06 in endemic pemphigus foliaceus in Brazil and to DRB1*04 in Italian patients suffering from pemphigus foliaceus (PF). The disease is caus...

journal_title：Journal of autoimmunity

authors： Loiseau P,Lecleach L,Prost C,Lepage V,Busson M,Bastuji-Garin S,Roujeau JC,Charron D

更新日期：2000-08-01 00:00:00

abstract：:Beta(2)-glycoprotein I (beta(2)GPI) is known as a major autoantigen for antiphospholipid antibodies. Our recent data show that binding of beta(2)GPI to oxidized low-density lipoprotein (oxLDL) or to liposomes containing anionic phospholipid(s) may facilitate the presentation of beta(2)GPI's epitope by macrophages/dend...

journal_title：Journal of autoimmunity

authors： Kajiwara T,Yasuda T,Matsuura E

更新日期：2007-09-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

journal_title：Journal of autoimmunity

authors： Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

更新日期：2001-09-01 00:00:00

abstract：:Previous studies have demonstrated increased expression of a laminin-like protein in labial salivary glands from Sjögren's syndrome (SS) patients. The objective of the present study was to verify the identity of this protein and to compare lymphocytic infiltration and laminin expression in minor salivary gland ductal ...

journal_title：Journal of autoimmunity

authors： McArthur CP,Daniels PJ,Kragel P,Howard PF,Julian L

更新日期：1997-02-01 00:00:00